Non-Gaussian fixed point in four-dimensional pure compact U(1) gauge theory on the lattice

The line of phase transitions, separating the confinement and the Coulomb phases in the four-dimensional pure compact U(1) gauge theory with extended Wilson action, is reconsidered. We present new numerical evidence that a part of this line, including the original Wilson action, is of second order. By means of a high precision simulation on homogeneous lattices on a sphere we find that along this line the scaling behavior is determined by one fixed point with distinctly non-Gaussian critical exponent nu = 0.365(8). This makes the existence of a nontrivial and nonasymptotically free four-dimensional pure U(1) gauge theory in the continuum very probable. The universality and duality arguments suggest that this conclusion holds also for the monopole loop gas, for the noncompact abelian Higgs model at large negative squared bare mass, and for the corresponding effective string theory.Comment: 11 pages, LaTeX, 2 figure

Four-dimensional pure compact U(1) gauge theory on a spherical lattice

We investigate the confinement-Coulomb phase transition in the four-dimensional (4D) pure compact U(1) gauge theory on spherical lattices. The action contains the Wilson coupling beta and the double charge coupling gamma. The lattice is obtained from the 4D surface of the 5D cubic lattice by its radial projection onto a 4D sphere, and made homogeneous by means of appropriate weight factors for individual plaquette contributions to the action. On such lattices the two-state signal, impeding the studies of this theory on toroidal lattices, is absent for gamma le 0. Furthermore, here a consistent finite-size scaling behavior of several bulk observables is found, with the correlation length exponent nu in the range nu = 0.35 - 40. These observables include Fisher zeros, specific-heat and cumulant extrema as well as pseudocritical values of beta at fixed gamma. The most reliable determination of nu by means of the Fisher zeros gives nu = 0.365(8). The phase transition at gamma le 0 is thus very probably of 2nd order and belongs to the universality class of a non-Gaussian fixed point.Comment: 40 pages, LaTeX, 12 figure

A combination of plasma phospholipid fatty acids and its association with incidence of type 2 diabetes: The EPIC-InterAct case-cohort study.

BACKGROUND: Combinations of multiple fatty acids may influence cardiometabolic risk more than single fatty acids. The association of a combination of fatty acids with incident type 2 diabetes (T2D) has not been evaluated. METHODS AND FINDINGS: We measured plasma phospholipid fatty acids by gas chromatography in 27,296 adults, including 12,132 incident cases of T2D, over the follow-up period between baseline (1991-1998) and 31 December 2007 in 8 European countries in EPIC-InterAct, a nested case-cohort study. The first principal component derived by principal component analysis of 27 individual fatty acids (mole percentage) was the main exposure (subsequently called the fatty acid pattern score [FA-pattern score]). The FA-pattern score was partly characterised by high concentrations of linoleic acid, stearic acid, odd-chain fatty acids, and very-long-chain saturated fatty acids and low concentrations of γ-linolenic acid, palmitic acid, and long-chain monounsaturated fatty acids, and it explained 16.1% of the overall variability of the 27 fatty acids. Based on country-specific Prentice-weighted Cox regression and random-effects meta-analysis, the FA-pattern score was associated with lower incident T2D. Comparing the top to the bottom fifth of the score, the hazard ratio of incident T2D was 0.23 (95% CI 0.19-0.29) adjusted for potential confounders and 0.37 (95% CI 0.27-0.50) further adjusted for metabolic risk factors. The association changed little after adjustment for individual fatty acids or fatty acid subclasses. In cross-sectional analyses relating the FA-pattern score to metabolic, genetic, and dietary factors, the FA-pattern score was inversely associated with adiposity, triglycerides, liver enzymes, C-reactive protein, a genetic score representing insulin resistance, and dietary intakes of soft drinks and alcohol and was positively associated with high-density-lipoprotein cholesterol and intakes of polyunsaturated fat, dietary fibre, and coffee (p < 0.05 each). Limitations include potential measurement error in the fatty acids and other model covariates and possible residual confounding. CONCLUSIONS: A combination of individual fatty acids, characterised by high concentrations of linoleic acid, odd-chain fatty acids, and very long-chain fatty acids, was associated with lower incidence of T2D. The specific fatty acid pattern may be influenced by metabolic, genetic, and dietary factors

UGCG influences glutamine metabolism of breast cancer cells

UDP-glucose ceramide glucosyltransferase (UGCG) is the key enzyme in glycosphingolipid (GSL) metabolism by being the only enzyme that generates glucosylceramide (GlcCer) de novo. Increased UGCG synthesis is associated with pro-cancerous processes such as increased proliferation and multidrug resistance in several cancer types. We investigated the influence of UGCG overexpression on glutamine metabolism in breast cancer cells. We observed adapted glucose and glutamine uptake in a limited energy supply environment following UGCG overexpression. Glutamine is used for reinforced oxidative stress response shown by increased mRNA expression of glutamine metabolizing proteins such as glutathione-disulfide reductase (GSR) resulting in increased reduced glutathione (GSH) level. Augmented glutamine uptake is also used for fueling the tricarboxylic acid (TCA) cycle to maintain the proliferative advantage of UGCG overexpressing cells. Our data reveal a link between GSL and glutamine metabolism in breast cancer cells, which is to our knowledge a novel correlation in the field of sphingolipid research