Reweaving urban water-community relations: Creative, participatory river “daylighting” and local hydrocitizenship

Framed by questions about ‘hydrocitizenship’ in the 21st century, this co-produced, interdisciplinary arts and humanities-centred research explores the (re)weaving of local knowledges, experiences, perceptions and values of water and place through the concept, process and practice of ‘daylighting hidden rivers’. Located at the nexus of three theoretical frames – ‘participation’, ‘hydrocitizenship’, and ‘daylighting’, it engages reflexively with strong and weak ‘hydrocitizenship’ and with paradigms of ‘daylighting’. Working with diverse communities and organisations in South Bristol (UK), this eco-social research project discovered community concerns and needs, and positioned itself in relation to these in co-production. This involved older people, children and professional stakeholders in a place-specific, ‘catchment’ setting, using novel arts-led, creative, narrative mapping processes. We critically examined the value, opportunities and tensions of this multi-method approach to people’s past, present and future connections and relationships with their local (water) environment, their senses of self and community. Our iterative processes of seeking out ‘lesser heard’ voices were conceived and played out around a braided cascade of ‘openings’: emerging, connecting, enacting, imagining and reflecting. Thinking critically about our oblique, emergent processes, we identify fifteen ‘top tips’ concerning the creative participatory daylighting of lay knowledges and values, and ‘River Visioning’. These can inform co-working with communities to enable and empower citizen engagement with places and local water issues for resilient futures. Our findings contribute new understandings of ‘hydrocitizenship’ and creative participatory ‘daylighting’ in combination, when urban spaces are construed as ‘Water Cities’, cascading both water and narratives. Importantly, our co-production processes with lesser heard groups also exemplify ‘higher-order participation’ in co-visioning resilient futures, with all the messiness, complexity and conflicts exposed

Differential effects of dietary supplements on metabolomic profile of smokers versus non-smokers.

BackgroundCigarette smoking is well-known to associate with accelerated skin aging as well as cardiovascular disease and lung cancer, in large part due to oxidative stress. Because metabolites are downstream of genetic variation, as well as transcriptional changes and post-translational modifications of proteins, they are the most proximal reporters of disease states or reversal of disease states.MethodsIn this study, we explore the potential effects of commonly available oral supplements (containing antioxidants, vitamins and omega-3 fatty acids) on the metabolomes of smokers (n = 11) compared to non-smokers (n = 17). At baseline and after 12 weeks of supplementation, metabolomic analysis was performed on serum by liquid and gas chromatography with mass spectroscopy (LC-MS and GC-MS). Furthermore, clinical parameters of skin aging, including cutometry as assessed by three dermatologist raters blinded to subjects' age and smoking status, were measured.ResultsLong-chain fatty acids, including palmitate and oleate, decreased in smokers by 0.76-fold (P = 0.0045) and 0.72-fold (P = 0.0112), respectively. These changes were not observed in non-smokers. Furthermore, age and smoking status showed increased glow (P = 0.004) and a decrease in fine wrinkling (P = 0.038). Cutometry showed an increase in skin elasticity in smokers (P = 0.049) but not in non-smokers. Complexion analysis software (VISIA) revealed decreases in the number of ultraviolet spots (P = 0.031), and cutometry showed increased elasticity (P = 0.05) in smokers but not non-smokers.ConclusionsAdditional future work may shed light on the specific mechanisms by which long-chain fatty acids can lead to increased glow, improved elasticity measures and decreased fine wrinkling in smokers' skin. Our study provides a novel, medicine-focused application of available metabolomic technology to identify changes in sera of human subjects with oxidative stress, and suggests that oral supplementation (in particular, commonly available antioxidants, vitamins and omega-3 fatty acids) affects these individuals in a way that is unique (compared to non-smokers) on a broad level

Seventy years of sex education in Health Education Journal: a critical review

This paper examines key debates and perspectives on sex education in Health Education Journal (HEJ), from the date of the journal’s first publication in March 1943 to the present day. Matters relating to sexuality and sexual health are revealed to be integral to HEJ’s history. First published as Health and Empire (1921 – 1942), a key purpose of the journal since its inception has been to share information on venereal disease and its prevention within the UK and across the former British Empire. From 1943 to the present day, discussions on sex education in the newly-christened HEJ both reflect and respond to evolving socio-cultural attitudes towards sexuality in the UK. Changing definitions of sex education across the decades are examined, from the prevention of venereal disease and moral decline in war-time Britain in the 1940s, to a range of responses to sexual liberation in the 1960s and 1970s; from a focus on preventing sexually-transmitted infections, teenage pregnancy and HIV in the 1980s, to the provision of sexual health services alongside sex education in the 2000s. Over the past 70 years, a shift from prevention of pre-marital sexual activity to the management of its outcomes is apparent; however, while these changes over time are notable, perhaps the most striking findings of this review are the continuities in arguments for and against the discussion of sexual issues. After more than 70 years of debate, it would seem that there is little consensus concerning motivations for and the content of sex education

High prevalence of extrapyramidal signs and symptoms in a group of Italian dental technicians

This is an Open Access article distributed under the terms of the Creative Commons Attribution Licens

In Vitro Aggregation Assays for the Characterization of \u3b1-synuclein Prion-Like Properties

Aggregation of \u3b1-synuclein plays a crucial role in the pathogenesis of synucleinopathies, a group of neurodegenerative diseases including Parkinson disease (PD), dementia with Lewy bodies (DLB), diffuse Lewy body disease (DLBD) and multiple system atrophy (MSA). The common feature of these diseases is a pathological deposition of protein aggregates, known as Lewy bodies (LBs) in the central nervous system. The major component of these aggregates is \u3b1-synuclein, a natively unfolded protein, which may undergo dramatic structural changes resulting in the formation of \u3b2-sheet rich assemblies. In vitro studies have shown that recombinant \u3b1-synuclein protein may polymerize into amyloidogenic fibrils resembling those found in LBs. These aggregates may be uptaken and propagated between cells in a prion-like manner. Here we present the mechanisms and kinetics of \u3b1-synuclein aggregation in vitro, as well as crucial factors affecting this process. We also describe how PD-linked \u3b1-synuclein mutations and some exogenous factors modulate in vitro aggregation. Furthermore, we present a current knowledge on the mechanisms by which extracellular aggregates may be internalized and propagated between cells, as well as the mechanisms of their toxicity. \ua9 2014 Landes Bioscience

Promoting water efficiency and hydrocitizenship in young people’s learning about drought risk in a temperate maritime country

Engaging young citizens with drought risk and positive water behaviours is essential in domestic water demand management within the wider climate crisis. This paper evaluates a new research-informed, picture book—‘DRY: The Diary of a Water Superhero’—that explores UK drought. The book’s development was underpinned by research within the Drought Risk and You (DRY) project. The book’s concept and storyline were co-produced by an interdisciplinary team, including a creative practitioner. This focused on key themes: drought definitions and types; drought myths; adaptation and young people’s (YP) agency. Characters and storyline were co-created to promote YP’s autonomy as change agents, and to encourage intergenerational and community learning. This paper evaluates the book from three perspectives: of YP, trainee teachers (TT) and teachers. Emergent themes are triangulated: drought as a sensitive issue, subject knowledge and changes in behaviour, and YP’s misconceptions about drought and place. TT also contemplated their improved subject knowledge and barriers to engaging with positive water behaviours. Teachers reflected on classroom use of the book, prior experiences about teaching drought, curriculum context and st/age of YP engaged. This paper reflects on how these insights feed into school practice and water industry outreach, in developing effective learning resources that promote a valuing of water, behaviour change and wider hydrocitizenship among YP and their communities

Cannabinoid use and effects in patients with epidermolysis bullosa:an international cross-sectional survey study

Abstract Background Epidermolysis bullosa (EB) patient anecdotes and case reports indicate that cannabinoid-based medicines (CBMs) may alleviate pain and pruritus and improve wound healing. CBM use has not been characterized in the EB patient population. Objectives To evaluate CBM use among EB patients, including CBM types, effects on symptoms (e.g., pain and pruritus), disease process (e.g., blistering, wounds, and inflammation), well-being (e.g., sleep, appetite) and concomitant medications. Methods English-speaking EB patients or caregivers completed an online international, anonymous, cross-sectional survey regarding CBM use. Respondents reported the types of CBMs, subsequent effects including perceived EB symptom alteration, changes in medication use, and side effects. Results Seventy-one EB patients from five continents reported using or having used CBMs to treat their EB. Missing question responses ranged between 0 (0%) and 33 (46%). Most used more than one CBM preparation (mean: 2.4 ± 1.5) and route of administration (mean: 2.1 ± 1.1). Topical and ingested were the most common routes. Pain and pruritus were reported retrospectively to decrease by 3 points (scale: 0–10; p < 0.001 for both) after CBM use. Most reported that CBM use improved their overall EB symptoms (95%), pain (94%), pruritus (91%) and wound healing (81%). Most participants (79%) reported decreased use of pain medications. The most common side-effect was dry mouth (44%). Conclusions CBMs improve the perception of pain, pruritus, wound healing, and well-being in EB patients and reduced concomitant medication use. Nevertheless, a direct relation between the use of CBMs and reduction of the above-mentioned symptoms cannot be proven by these data. Therefore, future controlled studies using pharmaceutically standardised CBM preparations in EB are warranted to delineate the risks and benefits of CBMs