The role of ultra-low-dose computed tomography in the detection of pulmonary pathologies : a prospective observational study

Purpose: The aim of the study was to compare the image noise, radiation dose, and image quality of ultra-low-dose computed tomography (CT) and standard CT in the imaging of pulmonary pathologies. Material and methods: This observational study was performed between July 2020 and August 2021. All enrolled patients underwent both ultra-low-dose and standard CTs. The image noise, image quality for normal pulmonary structures, presence or absence of various pulmonary lesions, and radiation dose were recorded for each of the scans. The findings of standard-dose CT were regarded as the gold standard and compared with that of ultra-low-dose CT. Results: A total of 124 patients were included in the study. The image noise was higher in the ultra-low-dose CT compared to standard-dose CT. The overall image quality was determined to be diagnostic in 100% of standard CT images and in 96.77% of ultra-low-dose CT images with proportional worsening of the image quality as the body mass index (BMI) range was increased. Ultra-low-dose CT offered higher (> 90%) sensitivity for lesions like consolidation (97%), pleural effusion (95%), fibrosis (92%), and solid pulmonary nodules (91%). The effective radiation dose (mSv) was many times lower in ultra-low-dose CT when compared to standard-dose CT (mean ± SD: 0.50 ± 0.005 vs. 3.99 ± 1.57). Conclusions: The radiation dose of ultra-low-dose chest CT was almost equal to that of a chest X-ray. It could be used for the screening and/or follow-up of patients with solid pulmonary nodules (> 3 mm) and consolidation

Spatial variability of biochemical composition in coral reef sediments of Kavaratti and Pitti islands, Lakshadweep archipelago

369-378In this study, variability of biochemical composition in the surficial coral reef sediments of Kavaratti and Pitti islands in Lakshadweeep archipelago was investigated. Biochemical composition of sedimentary organic matter from the study area was characterized by the dominance of proteins in Pitti and carbohydrates in Kavaratti over lipids. The percentage ratio of the labile to total organic matter indicated that most of the deposited organic matter was refractory in both environments. The higher PRT:CHO ratios in Pitti sediments compared to that of Kavaratti indicated that in the former there was low dead organic matter accumulation. The lower LPD:CHO ratios estimated for sediments in both islands indicated low quality of labile organic matter to support benthic fauna

Assessment of Radon in groundwater and associated human risk from Sankarabarani River Sub Basin, Southern India

Radon (222Rn) and associated human risk assessment in groundwater from quaternary shallow aquifers of Sankarabarani River sub basin, Southern India has been attempted by considering 41 groundwater samples and analysed for 222Rn using scintillation Radon monitoring system. The Radon ranges between 0.140±0.01 Bq l-1 to 7.869±0.33 Bq l-1 with an average of 1.797±0.12Bq l-1 and found to be within the maximum contamination level of Environmental Protection Agency (11.1 Bq l-1). The doses of ingestion and inhalation calculated for radon varies between 0.709 µSv y-1 to 39.933µSv y-1 with an average of 9.121µSv y-1which is within the prescribed dose limit of 100µSv y-1 by World Health Organisation. Uranium speciation attempted suggests saturated Haiweeite and Soddyite as sources for uranium/radon into the aquifer systems. The Eh-pH diagram suggests uraninite solubility within the pH ranges 6 to 8 within the groundwater environment

Investigation of Submarine Groundwater Discharge using Thermal Satellite and Radon mapping along the East Coast of the Tamil Nadu and Pondicherry Region, India

Submarine groundwater discharge (SGD) demarcated as a significant component of hydrological cycle found to discharge greater volumes of terrestrial fresh and recirculated seawater to the ocean associated with chemical constituents (nutrients, metals, and organic compounds) aided by downward hydraulic gradient and sediment-water exchange. Delineating SGD is of primal significance due to the transport of nutrients and contaminants due to domestic, industrial, and agricultural practices that influence the coastal water quality, ecosystems, and geochemical cycles. An attempt has been made to demarcate the SGD using thermal infrared images and radon-222 (222Rn) isotope. Thermal infrared images processed from LANDSAT-8 data suggest prominent freshwater fluxes with higher temperature anomalies noted in Cuddalore and Nagapattinam districts, and lower temperature noted along northern and southern parts of the study area suggest saline/recirculated discharge. Groundwater samples were collected along the coastal regions to analyze Radon and Physico-chemical constituents. Radon in groundwater ranges between 127.39 Bq m-3 and 2643.41 Bq m-3 with an average of 767.80 Bq m-3. Calculated SGD fluxes range between -1.0 to 26.5 with an average of 10.32 m day-1. Comparison of the thermal infrared image with physio-chemical parameters and Radon suggest fresh, terrestrial SGD fluxes confined to the central parts of the study area and lower fluxes observed along with the northern and southern parts of the study area advocate impact due to seawater intrusion and recirculated seawater influence

Estimating groundwater inputs from Sankarabarani River Basin, South India to the Bay of Bengal evaluated by Radium (226Ra) and nutrient fluxes

Sankarabarani river basin gains significance due to presence of major industrial, agricultural, urban development and tourist related activities has influenced the water quality in the estuarine environment.  Investigations about river water quality has been attempted but not more studies focus about the evaluation of groundwater discharge a significant process that connects groundwater and the coastal seawater have been attempted.  For the present study, radium (226Ra) a naturally occurring isotope was measured at three locations and used as effective tracers for estimating the groundwater discharge along with nutrient inputs to the Bay. Groundwater samples representing north east monsoon (December, 2017) has been collected during tidal variation in three locations (Location A- away from the coast towards inland, Location B-intermediate between Location A and the coast and Location C-at the estuary). 226Ra mass balance calculated groundwater fluxes irrespective of tidal variations were 2.27×108 m3/d, 2.19×108 m3/d and 5.22×107m3/d for A, B and C locations respectively. The nutrients like Dissolved inorganic nitrogen (DIN), Dissolved inorganic Phosphate (DIP) and Dissolved Silica (DSi) were found to be influencing the coastal groundwater by contributing fluxes to the sea of about 679.33 T mol/day. The study suggests increasing radium and nutrient fluxes to the Bay altering the coastal ecosystems would result in surplus algal blooms creating hypoxia

Polypill Eligibility for Patients with Heart Failure With Reduced Ejection Fraction in South India: A Secondary Analysis of a Prospective, Interrupted Time Series Study.

RESEARCH LETTER - No abstract available

Effect of a Quality Improvement Intervention on Clinical Outcomes in Patients in India With Acute Myocardial Infarction: The ACS QUIK Randomized Clinical Trial.

Importance: Wide heterogeneity exists in acute myocardial infarction treatment and outcomes in India. Objective: To evaluate the effect of a locally adapted quality improvement tool kit on clinical outcomes and process measures in Kerala, a southern Indian state. Design, Setting, and Participants: Cluster randomized, stepped-wedge clinical trial conducted between November 10, 2014, and November 9, 2016, in 63 hospitals in Kerala, India, with a last date of follow-up of December 31, 2016. During 5 predefined steps over the study period, hospitals were randomly selected to move in a 1-way crossover from the control group to the intervention group. Consecutively presenting patients with acute myocardial infarction were offered participation. Interventions: Hospitals provided either usual care (control group; n = 10 066 participants [step 0: n = 2915; step 1: n = 2649; step 2: n = 2251; step 3: n = 1422; step 4; n = 829; step 5: n = 0]) or care using a quality improvement tool kit (intervention group; n = 11 308 participants [step 0: n = 0; step 1: n = 662; step 2: n = 1265; step 3: n = 2432; step 4: n = 3214; step 5: n = 3735]) that consisted of audit and feedback, checklists, patient education materials, and linkage to emergency cardiovascular care and quality improvement training. Main Outcomes and Measures: The primary outcome was the composite of all-cause death, reinfarction, stroke, or major bleeding using standardized definitions at 30 days. Secondary outcomes included the primary outcome's individual components, 30-day cardiovascular death, medication use, and tobacco cessation counseling. Mixed-effects logistic regression models were used to account for clustering and temporal trends. Results: Among 21 374 eligible randomized participants (mean age, 60.6 [SD, 12.0] years; n = 16 183 men [76%] ; n = 13 689 [64%] with ST-segment elevation myocardial infarction), 21 079 (99%) completed the trial. The primary composite outcome was observed in 5.3% of the intervention participants and 6.4% of the control participants. The observed difference in 30-day major adverse cardiovascular event rates between the groups was not statistically significant after adjustment (adjusted risk difference, -0.09% [95% CI, -1.32% to 1.14%]; adjusted odds ratio, 0.98 [95% CI, 0.80-1.21]). The intervention group had a higher rate of medication use including reperfusion but no effect on tobacco cessation counseling. There were no unexpected adverse events reported. Conclusions and Relevance: Among patients with acute myocardial infarction in Kerala, India, use of a quality improvement intervention compared with usual care did not decrease a composite of 30-day major adverse cardiovascular events. Further research is needed to understand the lack of efficacy. Trial Registration: clinicaltrials.gov Identifier: NCT02256657

Efficacy of Quasi Agro Binding Fibre on the Hybrid Composite Used in Advance Application

The choice for natural fibre obtained from agricultural products is on the rise due to its solution to eco-friendly, environmental and improved mechanical properties concerns. Its abundant availability, low cost, emission reduction and adaptability to base material for composite make it a prime material for selection. This review explores diverse perspectives to the future trend of agro fibre in terms of the thermo-mechanical properties as it applies to advanced application in building structures. It is important to investigate the ecofriendliness of the products of composites from fibres in agricultural wastes so as to achieve a green and sustainable environment. This will come to fore by the combined efforts of both researchers and feedback from building stakeholders

Molecular markers and genetic diversity of Plasmodium vivax

Enhanced understanding of the transmission dynamics and population genetics for Plasmodium vivax is crucial in predicting the emergence and spread of novel parasite phenotypes with major public health implications, such as new relapsing patterns, drug resistance and increased virulence. Suitable molecular markers are required for these population genetic studies. Here, we focus on two groups of molecular markers that are commonly used to analyse natural populations of P. vivax. We use markers under selective pressure, for instance, antigen-coding polymorphic genes, and markers that are not under strong natural selection, such as most minisatellite and microsatellite loci. First, we review data obtained using genes encoding for P. vivax antigens: circumsporozoite protein, merozoite surface proteins 1 and 3α, apical membrane antigen 1 and Duffy binding antigen. We next address neutral or nearly neutral molecular markers, especially microsatellite loci, providing a complete list of markers that have already been used in P. vivax populations studies. We also analyse the microsatellite loci identified in the P. vivax genome project. Finally, we discuss some practical uses for P. vivax genotyping, for example, detecting multiple-clone infections and tracking the geographic origin of isolates