AN EXPLORATORY STUDY OF ELEMENTARY SCHOOL STUDENTS’ READING PERFORMANCE SCORES BEFORE AND AFTER COVID-19

The purpose of this study was to explore the reading performance scores of elementary school students in one school district before and after school closures due to COVID-19. This nonexperimental, exploratory study of quantitative, archival data was designed to explore a single cohort (N = 2,006) of third- through fifth-grade students’ i-Ready reading diagnostic scale scores from five different assessment periods: before school closures in spring 2020 and four subsequent assessment periods after face-to-face instruction resumed in fall 2020. The research sample excluded exceptional student education students and English language learners who had been retained. Mean scale scores of the research cohort were compared to the school district’s 2018-2019 i-Ready norms and to the 2018-2019 i-Ready national norms for each of the five assessment periods. The results of the comparisons revealed that the research cohort’s mean reading scale scores were significantly different from the district and national norm groups’ mean reading scale scores. The research sample’s mean reading scale scores were slightly higher than those of the target district’s norm group; however, the mean scores and the effect sizes were small. The research cohort’s reading scores were significantly lower than the scores of the 2018-2019 national norm group. Although the students in the research cohort demonstrated small increments of reading progress over time, the rate of progress was not commensurate with the 2018-2019 national norm group’s rate of progress. Keywords: COVID-19, pandemic, reading performance, reading achievement, elementary education, reading development, i-Read

The Buds and the Bees: Inquiry into the Sexual Reproduction of Plants

Many students have few significant experiences investigating flower structure and function, yet are expected to understand sexual reproduction in angiosperms. We present here an inquiry-based hands-on activity where middle school students compare plant reproduction to more commonly understood animal reproduction. This provides a foundation to more deeply understand topics related to plant reproduction. This activity also provides many opportunities to explicitly address the nature of science and how science works. This article addresses National Science Education Content Standards A, C, and G, and Iowa Teaching Standards 1, 2, 3, 4, and 5

The policy-practice gap: describing discordances between regulation on paper and real-life practices among specialized drug shops in Kenya.

BACKGROUND: Specialized drug shops (SDSs) are popular in Sub-Saharan Africa because they provide convenient access to medicines. There is increasing interest in how policymakers can work with them, but little knowledge on how their operation relates to regulatory frameworks. This study sought to describe characteristics and predictors of regulatory practices among SDSs in Kenya. METHODS: The regulatory framework governing the Kenya pharmaceutical sector was mapped, and a list of regulations selected for inclusion in a survey questionnaire. An SDS census was conducted, and survey data collected from 213 SDSs from two districts in Western Kenya. RESULTS: The majority of SDSs did not comply with regulations, with only 12% having a refrigerator and 22% having a separate dispensing area for instance. Additionally, less than half had at least one staff with pharmacy qualification (46%), with less than a third of all interviewed operators knowing the name of the law governing pharmacy.Regulatory infringement was more common among SDSs in rural locations; those that did not have staff with pharmacy qualifications; and those whose operator did not know the name of the pharmacy law. Compliance was not significantly associated with the frequency of inspections, with over 80% of both rural and urban SDSs reporting an inspection in the past year. CONCLUSION: While compliance was low overall, it was particularly poor among SDSs operating in rural locations, and those that did not have staff with pharmacy qualification. This suggested the need for policy to introduce levels of practice in recognition of the variations in resource availability. Under such a system, rural SDSs operating in low-resource setting, and selling a limited range of medicines, may be exempted from certain regulatory requirements, as long as their scope of practice is limited to certain essential services only. Future research should also explore why regulatory compliance is poor despite regular inspections

Fragment Grammars: Exploring Computation and Reuse in Language

Language relies on a division of labor between stored units and structure building operations which combine the stored units into larger structures. This division of labor leads to a tradeoff: more structure-building means less need to store while more storage means less need to compute structure. We develop a hierarchical Bayesian model called fragment grammar to explore the optimum balance between structure-building and reuse. The model is developed in the context of stochastic functional programming (SFP) and in particular using a probabilistic variant of Lisp known as the Church programming language (Goodman, Mansinghka, Roy, Bonawitz, & Tenenbaum, 2008). We show how to formalize several probabilistic models of language structure using Church, and how fragment grammar generalizes one of them---adaptor grammars (Johnson, Griffiths, & Goldwater, 2007). We conclude with experimental data with adults and preliminary evaluations of the model on natural language corpus data

APOBEC-related mutagenesis and neo-peptide hydrophobicity: implications for response to immunotherapy.

Tumor-associated neo-antigens are mutated peptides that allow the immune system to recognize the affected cell as foreign. Cells carrying excessive mutation load often develop mechanisms of tolerance. PD-L1/PD-1 checkpoint immunotherapy is a highly promising approach to overcome these protective signals and induce tumor shrinkage. Yet, the nature of the neo-antigens driving those beneficial responses remains unclear. Here, we show that APOBEC-related mutagenesis - a mechanism at the crossroads between anti-viral immunity and endogenous nucleic acid editing - increases neo-peptide hydrophobicity (a feature of immunogenicity), as demonstrated by in silico computation and in the TCGA pan-cancer cohort, where APOBEC-related mutagenesis was also strongly associated with immune marker expression. Moreover, APOBEC-related mutagenesis correlated with immunotherapy response in a cohort of 99 patients with diverse cancers, and this correlation was independent of the tumor mutation burden (TMB). Combining APOBEC-related mutagenesis estimate and TMB resulted in greater predictive ability than either parameter alone. Based on these results, further investigation of APOBEC-related mutagenesis as a marker of response to anti-cancer checkpoint blockade is warranted

Reading, Writing, and Learning with Incarcerated Youth

This interactive, panel presentation will challenge deficit perspectives as four teacher-researchers share their experiences reading and writing with incarcerated youth. Evidence-based curriculum and pedagogy that expands literacy instruction in correctional facilities will be shared, and the voices of students and teachers will be validated

Defining molecular initiating events in the adverse outcome pathway framework for risk assessment.

Consumer and environmental safety decisions are based on exposure and hazard data, interpreted using risk assessment approaches. The adverse outcome pathway (AOP) conceptual framework has been presented as a logical sequence of events or processes within biological systems which can be used to understand adverse effects and refine current risk assessment practices in ecotoxicology. This framework can also be applied to human toxicology and is explored on the basis of investigating the molecular initiating events (MIEs) of compounds. The precise definition of the MIE has yet to reach general acceptance. In this work we present a unified MIE definition: an MIE is the initial interaction between a molecule and a biomolecule or biosystem that can be causally linked to an outcome via a pathway. Case studies are presented, and issues with current definitions are addressed. With the development of a unified MIE definition, the field can look toward defining, classifying, and characterizing more MIEs and using knowledge of the chemistry of these processes to aid AOP research and toxicity risk assessment. We also present the role of MIE research in the development of in vitro and in silico toxicology and suggest how, by using a combination of biological and chemical approaches, MIEs can be identified and characterized despite a lack of detailed reports, even for some of the most studied molecules in toxicology.The authors acknowledge the financial support of Unilever.This is the accepted manuscript. The final published version is available from ACS at http://dx.doi.org/10.1021/tx500345

Predictors of Occupational Competence in People Hospitalized with Chronic Conditions

Background: Chronic diseases limit participation in meaningful daily activities, roles, and routines, which can negatively impact occupational competence, a sense of self, and life satisfaction, especially when hospitalization is required to manage disease symptoms. Standardized measures of occupational competence and related functional, cognitive, and environmental factors may enhance occupational therapists’ ability to identify potential barriers to and make targeted recommendations for self- and health management in the community. Method: This cross-sectional study investigated occupational competence in patients hospitalized with chronic conditions. The participants completed measures of occupational competence, values, self-care function, environmental impact, and functional cognition while hospitalized. Results: The participants (n = 51) reported moderate to high levels of occupational competence. The overall regression model was significant. Values, self-care function, and environmental impact were significant predictors of occupational competence. Conclusion: Values, self-care function, and environmental impact predict occupational competence in people hospitalized with chronic conditions. Occupational therapists should incorporate standardized measures of occupational competence, values, self-care function, and environmental impact into current evaluation practices to support recommendations for follow-up care and community supports. Future research should include a larger sample that is more representative of an occupational therapy caseload and incorporate alternative measures of functional cognition to better measure this construct