Review of physiotherapeutic methods used in patients with osteoporosis

Chłystek Joanna, Pietsch Julia, Golus Anna, Abramczyk Agata, Łakomski Mateusz. Review of physiotherapeutic methods used in patients with osteoporosis. Journal of Education, Health and Sport. 2018;8(9):1058-1066 eISNN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.1420053 http://ojs.ukw.edu.pl/index.php/johs/article/view/6004 https://pbn.nauka.gov.pl/sedno-webapp/works/877731 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part b item 1223 (26/01/2017). 1223 Journal of Education, Health and Sport eissn 2391-8306 7 © The Authors 2018; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 02.08.2018. Revised: 18.08.2018. Accepted: 15.09.2018. Review of physiotherapeutic methods used in patients with osteoporosis Joanna Chłystek, Julia Pietsch, Anna Golus, Agata Abramczyk, Mateusz Łakomski Department and Clinic of Geriatrics, Collegium Medicum in Bydgoszcz, University of Nicolaus Copernicus in Torun Abstract This article is a review of current literature about physiotherapeutic methods used in osteoporosis including physical activity and physical therapy. Osteoporosis is a systemic disease classified as a civilization disease, which is significantly associated with gender, age, low body weight, and lifestyle. Most often it concerns older adults and is also characteristic for postmenopausal women. The research presented in this article suggests the positive influence of physiotherapy (i.e. aerobic exercises and resistance training and also physical therapy) on osteogenic processes, bone mineral density, pain and decrease the risk of falls. Keywords: Osteoporosis, Physiotherapeutic method

The effect of physical activity on mood - a review of current literature

The impact of physical activity on human health has many benefits. Equally important in improving physical fitness and normalizing cardiovascular system seems to be the impact of exercise on mood of patients. Physical activity improves well-being, satisfaction and self-confidence. However, the condition of effective therapeutic intervention is due to its regularity, since only systematic exercises allow to maintain the beneficial effects of physical activity. Otherwise, the results achieved are only temporary. This article aims to review the current literature and show the most important aspects of motion therapy in improving the psychophysical condition of patients

Rehabilitation in rheumatoid arthritis

Rheumatoid arthritis is an inflammatory, chronic and progressive connective tissue disease. The causes of this disease are not fully known. About 0. 5 - 1. 5% of the population suffer from RA. This disease is more common in women. The treatment of RA should be comprehensive and include pharmacotherapy, physiotherapy and psychotherapy. It is also important to choose appropriate otropedic supplies. The presented studies indicate a positive effect of complex physiotherapeutic treatment on the reduction of pain and other symptoms of RA

Review of physiotherapeutic methods used in patients with osteoporosis

This article is a review of current literature about physiotherapeutic methods used in osteoporosis including physical activity and physical therapy. Osteoporosis is a systemic disease classified as a civilization disease, which is significantly associated with gender, age, low body weight, and lifestyle. Most often it concerns older adults and is also characteristic for postmenopausal women. The research presented in this article suggests the positive influence of physiotherapy (i.e. aerobic exercises and resistance training and also physical therapy) on osteogenic processes, bone mineral density, pain and decrease the risk of falls

Essential oils from the Herba and fruits of Peucedanum luxurians and their antituberculosis activity

The Apiaceae family has been accompanying people for thousands of years, being present in the kitchen, as well as in the pharmacy. Plants belonging to this family are well known as sources of coumarins and essential oils.                Essential oils from the Herba, as well as fruits, of Peucedanum luxurians Tamamsch. (an endemic umbelliferous plant taxon from Armenia) were obtained by hydrodistillation in a Deryng apparatus for the first time. The GC-MS analyses showed the presence of trans-β-farnesene (16%) and germacrene D (13%) as the most abundant components of the essential oils.                One of the most valuable properties of essential oils is their antimicrobial activity. It is a very desirable feature, especially in the case of some bacteria, which cause huge health problems. A good example is Mycobacterium tuberculosis, one of the leading causes of human morbidity and mortality.                The activity of essential oils from different parts of P. luxurians was tested for antituberculosis activity. Minimal Inhibitory Concentrations (MIC) values for the essential oils were determined by a 96-well microplate method with alamarBlue (Invitrogen). The inoculum of the reference strain of Mycobacterium tuberculosis H37Ra in Middlebrook 7H9 broth (Difco) was 5 x 105 cfu/mL per well, according to CLSI standards. Serial twofold dilutions of essential oils ranged from 8 to 256 µg/mL. As the internal control of the method, serial twofold dilutions of four first-line antibiotics dedicated to tuberculosis treatment: isoniazid (INH), rifampicin (RMP), ethambutol (EMB), and streptomycin (SM) were used [1,2]

Volatile compounds from different species of Lycopodium with anti-tuberculosis activity

Different species belonging to the genus Lycopodium L. (Lycopodiaceae) were used in folk medicine due to their antibacterial, healing effects on wounds, and properties used in the treatment of mental diseases, like amnesia, schizophrenia and different types of dementia.                Extracts containing volatiles obtained from different Lycopodium species: L. clavatum, L. annotinum, and Huperzia serrata (syn. Lycopodium serratum Thunb.), were tested against Mycobacterium tuberculosis. Dichloromethane and petroleum ether extracts of the mentioned species collected in different geographical sites (in Poland and Ukraine) have shown interesting activities.                Minimal Inhibitory Concentrations (MIC) values for the extracts were determined by a 96-well microplate method with alamarBlue (Invitrogen). The inoculum of the reference strain of Mycobacterium tuberculosis H37Ra in Middlebrook 7H9 broth (Difco) was 5 x 105 cfu/mL per well, according to CLSI standards. Serial twofold dilutions of the extracts ranged from 8 to 256 µg/mL. As the internal control of the method, serial twofold dilutions of four first-line antibiotics dedicated to tuberculosis treatment: isoniazid (INH), rifampicin (RMP), ethambutol (EMB), and streptomycin (SM) were used [1,2]

Untargetted Metabolomic Exploration of the Mycobacterium tuberculosis Stress Response to Cinnamon Essential Oil

The antimycobacterial activity of cinnamaldehyde has already been proven for laboratory strains and for clinical isolates. What is more, cinnamaldehyde was shown to threaten the mycobacterial plasma membrane integrity and to activate the stress response system. Following promising applications of metabolomics in drug discovery and development we aimed to explore the mycobacteria response to cinnamaldehyde within cinnamon essential oil treatment by untargeted liquid chromatography–mass spectrometry. The use of predictive metabolite pathway analysis and description of produced lipids enabled the evaluation of the stress symptoms shown by bacteria. This study suggests that bacteria exposed to cinnamaldehyde could reorganize their outer membrane as a physical barrier against stress factors. They probably lowered cell wall permeability and inner membrane fluidity, and possibly redirected carbon flow to store energy in triacylglycerols. Being a reactive compound, cinnamaldehyde may also contribute to disturbances in bacteria redox homeostasis and detoxification mechanisms

Antimycobacterial Activity of Cinnamaldehyde in a Mycobacterium tuberculosis(H37Ra) Model

The purpose of the study was to evaluate the antimycobacterial activity and the possible action mode of cinnamon bark essential oil and its main constituent—cinnamaldehyde—against the Mycobacterium tuberculosis ATCC 25177 strain. Cinnamaldehyde was proved to be the main bioactive compound responsible for mycobacterial growth inhibition and bactericidal effects. The antimycobacterial activity of cinnamaldehyde was found to be comparable with that of ethambutol, one of the first-line anti-TB antibiotics. The selectivity index determined using cell culture studies in vitro showed a high biological potential of cinnamaldehyde. In M. tuberculosis cells exposed to cinnamaldehyde the cell membrane stress sensing and envelope preserving system are activated. Overexpression of clgR gene indicates a threat to the stability of the cell membrane and suggests a possible mechanism of action. No synergism was detected with the basic set of antibiotics used in tuberculosis treatment: ethambutol, isoniazid, streptomycin, rifampicin, and ciprofloxacin

Nigella damascena L. Essential Oil—A Valuable Source of β-Elemene for Antimicrobial Testing

The most commonly used plant source of β-elemene is Curcuma wenyujin Y. H. Chen & C. Ling (syn. of Curcuma aromatic Salisb.) with its content in supercritical CO2 extract up to 27.83%. However, the other rich source of this compound is Nigella damascena L. essential oil, in which β-elemene accounts for 47%. In this work, the effective protocol for preparative isolation of β-elemene from a new source—N. damascena essential oil—using high performance counter-current chromatography HPCCC was elaborated. Furthermore, since sesquiterpens are known as potent antimicrobials, the need for finding new agents designed to combat multi-drug resistant strains was addressed and the purified target compound and the essential oil were tested for its activity against a panel of Gram-positive and Gram-negative bacteria, fungi, and mycobacterial strains. The application of the mixture of petroleum ether, acetonitrile, and acetone in the ratio 2:1.5:0.5 (v/v) in the reversed phase mode yielded β-elemene with high purity in 70 min. The results obtained for antimicrobial assay clearly indicated that N. damascena essential oil and isolated β-elemene exert action against Mycobacterium tuberculosis strain H37Ra

STAT3 and Its Pathways’ Dysregulation—Underestimated Role in Urological Tumors

Nowadays, molecular research is essential for the better understanding of tumor cells’ pathophysiology. The increasing number of neoplasms is taken under ‘the molecular magnifying glass’; therefore, it is possible to discover the complex relationships between cytophysiology and tumor cells. Signal transducer and activator of transcription 3 (STAT3) belongs to the family of latent cytoplasmic transcription factors called STATs, which comprises seven members: STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, and STAT6. Those proteins play important role in cytokine-activated gene expression by transducing signals from the cell membrane to the nucleus. Abnormal prolonged activation results in tumorigenesis, metastasis, cell proliferation, invasion, migration, and angiogenesis. Inhibition of this transcription factor inhibits the previously mentioned effects in cancer cells, whereas normal cells are not affected. Hence, STAT3 might be a viable target for cancer therapy