Non-holonomic Quantum Devices

We analyze the possibility and efficiency of non-holonomic control over quantum devices with exponentially large number of Hilbert space dimensions. We show that completely controllable devices of this type can be assembled from elementary units of arbitrary physical nature, and can be employed efficiently for universal quantum computations and simulation of quantum field dynamics.Comment: 8 revtex pages, 4 postscript figure

Non-Holonomic Control IV : Coherence Protection in a Rubidium isotope

In this paper, we present a realistic application of the coherence protection method proposed in the previous article. A qubit of information encoded on the two spin states of a Rubidium isotope is protected from the action of electric and magnetic fields

Non-Holonomic Control I

In this paper, we present a universal control technique, the non-holonomic control, which allows us to impose any arbitrarily prescribed unitary evolution to any quantum system through the alternate application of two well-chosen perturbations

Representação linguística da noção "crianças migrantes" na consciência naiva de oradores russos nativos

The article deals with the linguistic representation of the notion of "migrant children" in the naive consciousness of native Russian speakers. The notion under study correlates with the worldview as an integral image of the world in a person's mind. As the worldview is a multilevel phenomenon, there are different levels of generalization and representation of knowledge. Usually, the linguistic worldview is investigated precisely in relation to the specific ethnocultural features of a particular people and correlates with large ethnocultural groups. Based on the associates obtained as a result of a free association experiment, a field model of the concept of "migrant children" is developed.El artículo trata de la representación lingüística de la noción de "niños migrantes" en la conciencia ingenua de los hablantes nativos de ruso. La noción en estudio se correlaciona con la cosmovisión como una imagen integral del mundo en la mente de una persona. Como la cosmovisión es un fenómeno multinivel, existen diferentes niveles de generalización y representación del conocimiento. Por lo general, la cosmovisión lingüística se investiga precisamente en relación con las características etnoculturales específicas de un pueblo en particular y se correlaciona con grandes grupos etnoculturales. A partir de los asociados obtenidos como resultado de un experimento de libre asociación, se desarrolla un modelo de campo del concepto de "niños migrantes".O artigo trata da representação linguística da noção de "crianças migrantes" na consciência ingênua de falantes nativos de russo. A noção em estudo se correlaciona com a visão de mundo como uma imagem integral do mundo na mente de uma pessoa. Como a cosmovisão é um fenômeno multinível, existem diferentes níveis de generalização e representação do conhecimento. Normalmente, a visão de mundo linguística é investigada precisamente em relação às características etnoculturais específicas de um determinado povo e se correlaciona com grandes grupos etnoculturais. Com base nos associados obtidos como resultado de uma experiência de associação livre, é desenvolvido um modelo de campo do conceito de "crianças migrantes"

Emergent SARS-CoV-2 variants: comparative replication dynamics and high sensitivity to thapsigargin

The struggle to control the COVID-19 pandemic is made challenging by the emergence of virulent SARS-CoV-2 variants. To gain insight into their replication dynamics, emergent Alpha (A), Beta (B) and Delta (D) SARS-CoV-2 variants were assessed for their infection performance in single variant- and co-infections. The effectiveness of thapsigargin (TG), a recently discovered broad-spectrum antiviral, against these variants was also examined. Of the 3 viruses, the D variant exhibited the highest replication rate and was most able to spread to in-contact cells; its replication rate at 24h post-infection (hpi) based on progeny viral RNA production was over 4 times that of variant A and 9 times more than the B variant. In co-infections, the D variant boosted the replication of its co-infected partners at the expense of its own initial performance. Furthermore, co-infection with AD or AB combination conferred replication synergy where total progeny (RNA) output was greater than the sum of corresponding single-variant infections. All variants were highly sensitive to TG inhibition. A single pre-infection priming dose of TG effectively blocked all single-variant infections and every combination (AB, AD, BD variants) of co-infection at greater than 95% (relative to controls) at 72hpi. Likewise, TG was effective in inhibiting each variant in active preexisting infection. In conclusion, against the current backdrop of the dominant D variant that could be further complicated by co-infection synergy with new variants, the growing list of viruses susceptible to TG, a promising host-centric antiviral, now includes a spectrum of contemporary SARS-CoV-2 viruses

Thapsigargin Is a Broad-Spectrum Inhibitor of Major Human Respiratory Viruses: Coronavirus, Respiratory Syncytial Virus and Influenza A Virus

The long-term control strategy of SARS-CoV-2 and other major respiratory viruses needs to in-clude antivirals to treat acute infections, in addition to the judicious use of effective vaccines. Whilst COVID-19 vaccines are being rolled out for mass vaccination, the modest number of an-tivirals in use or development for any disease bears testament to the challenges of antiviral de-velopment. We recently showed that non-cytotoxic levels of thapsigargin (TG), an inhibitor of the sarcoplasmic / endoplasmic reticulum (ER) Ca2+ ATPase pump, induces a potent host innate immune antiviral response that blocks influenza A virus replication. Here we show that TG is also highly effective in blocking the replication of respiratory syncytial virus (RSV), common cold coronavirus OC43, SARS-CoV-2 and influenza A virus in immortalized or primary human cells. TG’s antiviral performance was significantly better than remdesivir and ribavirin in their respective inhibition of OC43 and RSV. Notably, TG was just as inhibitory to coronaviruses (OC43 and SARS-CoV-2) and influenza viruses (USSR H1N1 and pdm 2009 H1N1) in separate in-fections as in co-infections. Post-infection oral gavage of acid-stable TG protected mice against lethal influenza virus challenge. Together with its ability to inhibit the different viruses before or during active infection, and with an antiviral duration of at least 48 h post-TG exposure, we propose that TG (or its derivatives) is a promising broad-spectrum inhibitor against SARS-CoV-2, OC43, RSV and influenza virus

Oral particle uptake and organ targeting drives the activity of amphotericin B nanoparticles

There are very few drug delivery systems that target key organs via the oral route, as oral delivery advances normally address gastrointestinal drug dissolution, permeation, and stability. Here we introduce a nanomedicine in which nanoparticles, while also protecting the drug from gastric degradation, are taken up by the gastrointestinal epithelia and transported to the lung, liver, and spleen, thus selectively enhancing drug bioavailability in these target organs and diminishing kidney exposure (relevant to nephrotoxic drugs). Our work demonstrates, for the first time, that oral particle uptake and translocation to specific organs may be used to achieve a beneficial therapeutic response. We have illustrated this using amphotericin B, a nephrotoxic drug encapsulated within <i>N</i>-palmitoyl-<i>N</i>-methyl-<i>N</i>,<i>N</i>-dimethyl-<i>N</i>,<i>N</i>,<i>N</i>-trimethyl-6-<i>O</i>-glycol chitosan (GCPQ) nanoparticles, and have evidenced our approach in three separate disease states (visceral leishmaniasis, candidiasis, and aspergillosis) using industry standard models of the disease in small animals. The oral bioavailability of AmB-GCPQ nanoparticles is 24%. In all disease models, AmB-GCPQ nanoparticles show comparable efficacy to parenteral liposomal AmB (AmBisome). Our work thus paves the way for others to use nanoparticles to achieve a specific targeted delivery of drug to key organs via the oral route. This is especially important for drugs with a narrow therapeutic index