A stereographic representation of Knoop hardness anisotropy

Indentation direction parameter for hardness anisotropy representation of single crystal on stereographic triangl

European Railway Comparisons: Final Report

The Institute for Transport Studies (ITS), University of Leeds and the British Railways Board (BRB) carried out a major comparative study of Western European railways in the late 1970s (BRB and University of Leeds, 1979). Follow-up work was carried out by ITS financed by the Social Science Research Council and reported by Nash (1985). It was deaded to revive this work at ITS for a number of reasons: It is over ten years since the last set of comparisons (for 1981) were made at ITS and therefore a review of the changes in costs and productivity may be timely. There has been a number of technical developments that make the use of statistical cost analysis more promising. These developments include the use of more flexible functional forms such as the translog, and the development of comprehensive total factor productivity indices (see, for example, Dodgson, 1985 and, more recently, Hensher and Waters, 1993). There is increasing interest in the organisational structure of railway industries as a result of the 1988 Transport Act in Sweden, the EC directive 91/4-40 and the publication of proposals for privatising British Rail in July 1992 (see, for example, ECMT, 1993). Given the explosion in information technology, there were some hopes that data availability would have improved. (Continues..

Deep learning for novel antimicrobial peptide design

Antimicrobial resistance is an increasing issue in healthcare as the overuse of antibacterial agents rises during the COVID-19 pandemic. The need for new antibiotics is high, while the arsenal of available agents is decreasing, especially for the treatment of infections by Gram-negative bacteria like Escherichia coli. Antimicrobial peptides (AMPs) are offering a promising route for novel antibiotic development and deep learning techniques can be utilised for successful AMP design. In this study, a long short-term memory (LSTM) generative model and a bidirectional LSTM classification model were constructed to design short novel AMP sequences with potential antibacterial activity against E. coli. Two versions of the generative model and six versions of the classification model were trained and optimised using Bayesian hyperparameter optimisation. These models were used to generate sets of short novel sequences that were classified as antimicrobial or non-antimicrobial. The validation accuracies of the classification models were 81.6–88.9% and the novel AMPs were classified as antimicrobial with accuracies of 70.6–91.7%. Predicted three-dimensional conformations of selected short AMPs exhibited the alpha-helical structure with amphipathic surfaces. This demonstrates that LSTMs are effective tools for generating novel AMPs against targeted bacteria and could be utilised in the search for new antibiotics leads

Stick-slip instability for viscous fingering in a gel

The growth dynamics of an air finger injected in a visco-elastic gel (a PVA/borax aqueous solution) is studied in a linear Hele-Shaw cell. Besides the standard Saffmann-Taylor instability, we observe - with increasing finger velocities - the existence of two new regimes: (a) a stick-slip regime for which the finger tip velocity oscillates between 2 different values, producing local pinching of the finger at regular intervals, (b) a ``tadpole'' regime where a fracture-type propagation is observed. A scaling argument is proposed to interpret the dependence of the stick-slip frequency with the measured rheological properties of the gel.Comment: 7 pages, 4 figures. Submitted to Europhysics Letter

Growth of Perturbation in Gravitational Collapse and Accretion

When a self-gravitating spherical gas cloud collapses or accretes onto a central mass, the inner region of the cloud develops a density profile $\rho\propto r^{-3/2}$ and the velocity approaches free-fall. We show that in this region, nonspherical perturbations grow with decreasing radius. In the linear regime, the tangential velocity perturbation increases as $r^{-1}$, while the Lagrangian density perturbation, $\Delta\rho/\rho$, grows as $r^{-1/2}$. Faster growth occurs if the central collapsed object maintains a finite multiple moment, in which case $\Delta\rho/\rho$ increases as $r^{-l}$, where $l$ specifies the angular degree of the perturbation. These scaling relations are different from those obtained for the collapse of a homogeneous cloud. Our numerical calculations indicate that nonspherical perturbations are damped in the subsonic region, and that they grow and approach the asymptotic scalings in the supersonic region. The implications of our results to asymmetric supernova collapse and to black hole accretion are briefly discussed.Comment: 23 pages including 6 ps figures; Minor changes and update; To appear in ApJ, 200

Global summary of baseline household survey results

This report summarises the results of a baseline household-level survey, designed by the CCAFS team and implemented in late 2010/early 2011 in 3 regions: East Africa, West Africa and South Asia. This survey was designed with the intent of developing simple, comparable cross-site household level indicators, for which changes can be evaluated over time, of food security, households assets, agricultural production diversity, agricultural sales diversity, changes being made in farming practices for adaptation, innovation, and/or to help reduce emissions or store greenhouse gases (mitigation), and gender indicators (e.g. men’s versus women’s reception of weather-related information). A standardised survey, guidelines and training materials were implemented across 12 countries in West Africa (Senegal, Mali, Burkina Faso, Niger, and Ghana), East Africa (Kenya, Uganda, Ethiopia, and Tanzania), and South Asia (India, Nepal and Bangladesh). Thus we have a total of 15 core sites covering 108 villages and 2095 households. This summary report gives an overview of the farming practices, and asset, livelihoods and food security status of rural households in these sites. It describes what changes farmers have been making in recent years with respect to crop management, livestock practices, use of inputs and other agricultural practices. We explore what kinds of weather/climate and associated information these households are receiving, how and by whom. This information provides important baseline information, as these households will be revisited in 5-10 years’ time in order to evaluate the changes in these indicators. This will give us important information as to if, how, and which households are adapting to a changing climate while improving their food security status

Perturbations on steady spherical accretion in Schwarzschild geometry

The stationary background flow in the spherically symmetric infall of a compressible fluid, coupled to the space-time defined by the static Schwarzschild metric, has been subjected to linearized perturbations. The perturbative procedure is based on the continuity condition and it shows that the coupling of the flow with the geometry of space-time brings about greater stability for the flow, to the extent that the amplitude of the perturbation, treated as a standing wave, decays in time, as opposed to the amplitude remaining constant in the Newtonian limit. In qualitative terms this situation simulates the effect of a dissipative mechanism in the classical Bondi accretion flow, defined in the Newtonian construct of space and time. As a result of this approach it becomes impossible to define an acoustic metric for a conserved spherically symmetric flow, described within the framework of Schwarzschild geometry. In keeping with this view, the perturbation, considered separately as a high-frequency travelling wave, also has its amplitude reduced.Comment: 8 pages, no figur

Realizability of stationary spherically symmetric transonic accretion

The spherically symmetric stationary transonic (Bondi) flow is considered a classic example of an accretion flow. This flow, however, is along a separatrix, which is usually not physically realizable. We demonstrate, using a pedagogical example, that it is the dynamics which selects the transonic flow.Comment: 4 pages in REVTeX with 2 figures. Typos have been corrected and some alterations have been made in the version published in Physical Review

Secular instability in quasi-viscous disc accretion

A first-order correction in the $\alpha$-viscosity parameter of Shakura and Sunyaev has been introduced in the standard inviscid and thin accretion disc. A linearised time-dependent perturbative study of the stationary solutions of this "quasi-viscous" disc leads to the development of a secular instability on large spatial scales. This qualitative feature is equally manifest for two different types of perturbative treatment -- a standing wave on subsonic scales, as well as a radially propagating wave. Stability of the flow is restored when viscosity disappears.Comment: 15 pages, 2 figures, AASTeX. Added some new material and upgraded the reference lis