5,913 research outputs found
Corrigendum: tracing the origins of the Pituitary Adenylate-Cyclase Activating Polypeptide (PACAP)
A Corrigendum on
Tracing the Origins of the Pituitary Adenylate-Cyclase Activating Polypeptide (PACAP)
by Cardoso, J. C. R., Garcia, M. G., and Power, D. M. (2020). Front. Neurosci. 14:366.
doi: 10.3389/fnins.2020.00366
In the original article, there was amistake in the legend for Table 1 as published. The table describes
nomenclature for both vertebrates and non-vertebrates.
In the original article, there was a mistake in Table 1 as published. PACAP receptor
nomenclature for teleost and Actinopterygii (non-teleost) has errors. The Agnathan PACAP
Receptor Gene/transcript should not be Adcyap1r1. During production, PACAP peptide column
was erroneously positioned under the PACAP receptor. The corrected Table 1 and legend
appears below.
The authors apologize for this error and state that this does not change the scientific conclusions
of the article in any way. The original article has been updated.info:eu-repo/semantics/publishedVersio
Local Delivery of Therapeutics to the Inner Ear: The State of the Science
BACKGROUND: Advances in the understanding of the genetic and molecular etiologies of inner ear disorders have enabled the identification of therapeutic targets and innovative delivery approaches to the inner ear. As this field grows, the need for knowledge about effective delivery of therapeutics to the inner ear has become a priority. This review maps all clinical and pre-clinical research published in English in the field to date, to guide both researchers and clinicians about local drug delivery methods in the context of novel therapeutics. METHODS: A systematic search was conducted using customized strategies in Cochrane, pubmed and EMBASE databases from inception to 30/09/2018. Two researchers undertook study selection and data extraction independently. RESULTS: Our search returned 12,200 articles, of which 837 articles met the inclusion criteria. 679 were original research and 158 were reviews. There has been a steady increase in the numbers of publications related to inner ear therapeutics delivery over the last three decades, with a sharp rise over the last 2 years. The intra-tympanic route accounts for over 70% of published articles. Less than one third of published research directly assesses delivery efficacy, with most papers using clinical efficacy as a surrogate marker. CONCLUSION: Research into local therapeutic delivery to the inner ear has undergone a recent surge, improving our understanding of how novel therapeutics can be delivered. Direct assessment of delivery efficacy is challenging, especially in humans, and progress in this area is key to understanding how to make decisions about delivery of novel hearing therapeutics
A retrospective review of post-metamorphic mountain chicken frog (leptodactylus fallax) necropsy findings from European zoological collections, 1998 to 2018
The mountain chicken frog (Leptodactylus fallax) is the largest endemic amphibian species in the Western Hemisphere. Since 1998, this critically endangered species has been maintained as a European Endangered Species Programme, but low breeding success and a high mortality rate threaten the sustainability of the captive frog population. In the current study, we analyzed gross and histopathologic postmortem information from 212 mountain chicken frogs that died in European zoological collections from 1998 to 2018. Thin body condition was the most commonly reported finding across all submissions, observed in 125 frogs. The gastrointestinal and urinary systems were reported to have the highest prevalence of pathologic findings on gross and histopathologic examination. Inflammatory disease was the most frequent diagnosis after histopathologic examination of relevant tissues, with intestinal inflammatory disease (n = 76) followed by tubulointerstitial nephritis (n = 26) being the most commonly reported. Neoplasia was reported in 42 of 212 (19.8%) frogs, all of which were adults. A defined cause of death, or reason for euthanasia, was proposed for 164 of 212 (77.4%) frogs, with inflammatory diseases processes (74 of 212; 34.9%) most commonly implicated. Intestinal adenocarcinoma, seemingly restricted to the colon, caused the deaths of 31 adult frogs. Further investigations to determine factors contributing to the high incidence of inflammatory disease processes and neoplasia are advocated to improve the health and sustainability of the captive mountain chicken frog population
Development of a dynamic framework to explain population patterns of leisure-time physical activity through agent-based modeling.
Despite the increasing body of evidences on the factors influencing leisure-time physical activity, our understanding of the mechanisms and interactions that lead to the formation and evolution of population patterns is still limited. Moreover, most frameworks in this field fail to capture dynamic processes. Our aim was to create a dynamic conceptual model depicting the interaction between key psychological attributes of individuals and main aspects of the built and social environments in which they live. This conceptual model will inform and support the development of an agent-based model aimed to explore how population patterns of LTPA in adults may emerge from the dynamic interplay between psychological traits and built and social environments. We integrated existing theories and models as well as available empirical data (both from literature reviews), and expert opinions (based on a systematic expert assessment of an intermediary version of the model). The model explicitly presents intention as the proximal determinant of leisure-time physical activity, a relationship dynamically moderated by the built environment (access, quality, and available activities) - with the strength of the moderation varying as a function of the person's intention- and influenced both by the social environment (proximal network's and community's behavior) and the person's behavior. Our conceptual model is well supported by evidence and experts' opinions and will inform the design of our agent-based model, as well as data collection and analysis of future investigations on population patterns of leisure-time physical activity among adults
Early Trends in Cystatin C and Outcomes in Patients with Cirrhosis and Acute Kidney Injury
Background. Acute kidney injury (AKI) is a common and severe complication in patients with cirrhosis. Progression of AKI to a higher stage associates with increased mortality. Intervening early in AKI when renal dysfunction is worsening may improve outcomes. However, serum creatinine correlates poorly with glomerular filtration in patients with cirrhosis and fluctuations may mask progression early in the course of AKI. Cystatin C, a low-molecular-weight cysteine proteinase inhibitor, is a potentially more accurate marker of glomerular filtration. Methods. We conducted a prospective multicenter study in patients with cirrhosis comparing changes in cystatin and creatinine immediately following onset of AKI as predictors of a composite endpoint of dialysis or mortality. Results. Of 106 patients, 37 (35%) met the endpoint. Cystatin demonstrated less variability between samples than creatinine. Patients were stratified into four groups reflecting changes in creatinine and cystatin: both unchanged or decreased 38 (36%) (Scr−/CysC−); only cystatin increased 25 (24%) (Scr−/CysC+); only creatinine increased 15 (14%) (Scr+/CysC−); and both increased 28 (26%) (Scr+/CysC+). With Scr−/CysC− as the reference, in both instances where cystatin rose, Scr−/CysC+ and Scr+/CysC+, the primary outcome was significantly more frequent in multivariate analysis, and , respectively. However, when only creatinine rose, outcomes were similar to the reference group. Conclusions. Changes in cystatin levels early in AKI are more closely associated with eventual dialysis or mortality than creatinine and may allow more rapid identification of patients at risk for adverse outcomes
A Dataset and Baselines for Visual Question Answering on Art
Answering questions related to art pieces (paintings) is a difficult task, as
it implies the understanding of not only the visual information that is shown
in the picture, but also the contextual knowledge that is acquired through the
study of the history of art. In this work, we introduce our first attempt
towards building a new dataset, coined AQUA (Art QUestion Answering). The
question-answer (QA) pairs are automatically generated using state-of-the-art
question generation methods based on paintings and comments provided in an
existing art understanding dataset. The QA pairs are cleansed by crowdsourcing
workers with respect to their grammatical correctness, answerability, and
answers' correctness. Our dataset inherently consists of visual
(painting-based) and knowledge (comment-based) questions. We also present a
two-branch model as baseline, where the visual and knowledge questions are
handled independently. We extensively compare our baseline model against the
state-of-the-art models for question answering, and we provide a comprehensive
study about the challenges and potential future directions for visual question
answering on art
Unusual Thermodynamics on the Fuzzy 2-Sphere
Higher spin Dirac operators on both the continuum sphere() and its fuzzy
analog() come paired with anticommuting chirality operators. A
consequence of this is seen in the fermion-like spectrum of these operators
which is especially true even for the case of integer-spin Dirac operators.
Motivated by this feature of the spectrum of a spin 1 Dirac operator on
, we assume the spin 1 particles obey Fermi-Dirac statistics. This
choice is inspite of the lack of a well defined spin-statistics relation on a
compact surface such as . The specific heats are computed in the cases of
the spin and spin 1 Dirac operators. Remarkably the specific heat
for a system of spin particles is more than that of the spin 1
case, though the number of degrees of freedom is more in the case of spin 1
particles. The reason for this is inferred through a study of the spectrums of
the Dirac operators in both the cases. The zero modes of the spin 1 Dirac
operator is studied as a function of the cut-off angular momentum and is
found to follow a simple power law. This number is such that the number of
states with positive energy for the spin 1 and spin system become
comparable. Remarks are made about the spectrums of higher spin Dirac operators
as well through a study of their zero-modes and the variation of their spectrum
with degeneracy. The mean energy as a function of temperature is studied in
both the spin and spin 1 cases. They are found to deviate from
the standard ideal gas law in 2+1 dimensions.Comment: 19 pages, 7 figures. The paper has been significantly modified. Main
results are unchange
A model for selection of eyespots on butterfly wings
The development of eyespots on the wing surface of butterflies of the family Nympalidae is one of the most studied examples of biological pattern formation.However, little is known about the mechanism that determines the number and precise locations of eyespots on the wing. Eyespots develop around signaling centers, called foci, that are located equidistant from wing veins along the midline of a wing cell (an area bounded by veins). A fundamental question that remains unsolved is, why a certain wing cell develops an eyespot, while other wing cells do not. We illustrate that the key to understanding focus point selection may be in the venation system of the wing disc. Our main hypothesis is that changes in morphogen concentration along the proximal boundary veins of wing cells govern focus point selection. Based on previous studies, we focus on a spatially two-dimensional reaction-diffusion system model posed in the interior of each wing cell that describes the formation of focus points. Using finite element based numerical simulations, we demonstrate that variation in the proximal boundary condition is sufficient to robustly select whether an eyespot focus point forms in otherwise identical wing cells. We also illustrate that this behavior is robust to small perturbations in the parameters and geometry and moderate levels of noise. Hence, we suggest that an anterior-posterior pattern of morphogen concentration along the proximal vein may be the main determinant of the distribution of focus points on the wing surface. In order to complete our model, we propose a two stage reaction-diffusion system model, in which an one-dimensional surface reaction-diffusion system, posed on the proximal vein, generates the morphogen concentrations that act as non-homogeneous Dirichlet (i.e., fixed) boundary conditions for the two-dimensional reaction-diffusion model posed in the wing cells. The two-stage model appears capable of generating focus point distributions observed in nature.
We therefore conclude that changes in the proximal boundary conditions are sufficient to explain the empirically observed distribution of eyespot focus points on the entire wing surface. The model predicts, subject to experimental verification, that the source strength of the activator at the proximal boundary should be lower in wing cells in which focus points form than in those that lack focus points. The model suggests that the number and locations of eyespot foci on the wing disc could be largely controlled by two kinds of gradients along two different directions, that is, the first one is the gradient in spatially varying parameters such as the reaction rate along the anterior-posterior direction on the proximal boundary of the wing cells, and the second one is the gradient in source values of the activator along the veins in the proximal-distal direction of the wing cell
The "Solar Model Problem" Solved by the Abundance of Neon in Stars of the Local Cosmos
The interior structure of the Sun can be studied with great accuracy using
observations of its oscillations, similar to seismology of the Earth. Precise
agreement between helioseismological measurements and predictions of
theoretical solar models has been a triumph of modern astrophysics (Bahcall et
al. 2005). However, a recent downward revision by 25-35% of the solar
abundances of light elements such as C, N, O and Ne (Asplund et al. 2004) has
broken this accordance: models adopting the new abundances incorrectly predict
the depth of the convection zone, the depth profiles of sound speed and
density, and the helium abundance (Basu Antia 2004, Bahcall et al. 2005). The
discrepancies are far beyond the uncertainties in either the data or the model
predictions (Bahcall et al. 2005b). Here we report on neon abundances relative
to oxygen measured in a sample of nearby solar-like stars from their X-ray
spectra. They are all very similar and substantially larger than the recently
revised solar value. The neon abundance in the Sun is quite poorly determined.
If the Ne/O abundance in these stars is adopted for the Sun the models are
brought back into agreement with helioseismology measurements (Antia Basu 2005,
Bahcall et al. 2005c).Comment: 13 pages, 3 Figure
Statin Induced Myopathy and Myalgia: Time Trend Analysis and Comparison of Risk Associated with Statin Class from 1991–2006
BACKGROUND: Statins are widely used as a cholesterol lowering medication, reduce cardiovascular mortality and morbidity in high risk patients; and only rarely cause serious adverse drug reactions (ADRs). UK primary care databases of morbidity and prescription data, which now cover several million people, have potential for more powerful analytical approaches to study ADRs including adjusting for confounders and examining temporal effects. METHODS: Case-crossover design in detecting statin associated myopathy ADR in 93, 831 patients, using two independent primary care databases (1991-2006). We analysed risk by drug class, by disease code and cumulative year, exploring different cut-off exposure times and confounding by temporality. RESULTS: Using a 12 and 26 week exposure period, large risk ratios (RR) are associated with all classes of statins and fibrates for myopathy: RR 10.6 (9.8-11.4) and 19.9 (17.6-22.6) respectively. At 26 weeks, the largest risks are with fluvastatin RR 33.3 (95% CI 16.8-66.0) and ciprofibrate (with previous statin use) RR 40.5 (95% CI 13.4-122.0). AT 12 weeks the differences between cerivastatin and atorvastatin RR for myopathy were found to be significant, RR 2.05 (95% CI 1.2-3.5), and for rosuvastatin and fluvastatin RR 3.0 (95% CI 1.6-5.7). After 12 months of statin initiation, the relative risk for myopathy for all statins and fibrates increased to 25.7 (95% CI 21.8-30.3). Furthermore, this signal was detected within 2 years of first events being recorded. Our data suggests an annual incidence of statin induced myopathy or myalgia of around 11.4 for 16, 591 patients or 689 per million per year. CONCLUSION: There may be differential risks associated with some classes of statin and fibrate. Myopathy related to statin or fibrate use may persist after a long exposure time (12 months or more). These methods could be applied for early detection of harmful drug side effects, using similar primary care diagnostic and prescribing data
- …