2-(4,6-Dimethyl­pyrimidin-2-ylsulfan­yl)-N-(4-methyl­pyridin-2-yl)acetamide

The non-H atoms of the title mol­ecule, C14H16N4OS, are coplanar, with an r.m.s. deviation of 0.039 Å. The dihedral angle between the two aromatic rings is 2.4 (2)°. An intra­molecular C—H⋯O hydrogen bond is observed. The mol­ecules exist as N—H⋯N hydrogen-bonded centrosymmetric dimers

miRNA-mRNA-protein dysregulated network in COPD in women

Rationale: Chronic obstructive pulmonary disease (COPD) is a complex disease caused by a multitude of underlying mechanisms, and molecular mechanistic modeling of COPD, especially at a multi-molecular level, is needed to facilitate the development of molecular diagnostic and prognostic tools and efficacious treatments.Objectives: To investigate the miRNA-mRNA-protein dysregulated network to facilitate prediction of biomarkers and disease subnetwork in COPD in women.Measurements and Results: Three omics data blocks (mRNA, miRNA, and protein) collected from BAL cells from female current-smoker COPD patients, smokers with normal lung function, and healthy never-smokers were integrated with miRNA-mRNA-protein regulatory networks to construct a COPD-specific dysregulated network. Furthermore, downstream network topology, literature annotation, and functional enrichment analysis identified both known and novel disease-related biomarkers and pathways. Both abnormal regulations in miRNA-induced mRNA transcription and protein translation repression play roles in COPD. Finally, the let-7-AIFM1-FKBP1A pathway is highlighted in COPD pathology.Conclusion: For the first time, a comprehensive miRNA-mRNA-protein dysregulated network of primary immune cells from the lung related to COPD in females was constructed to elucidate specific biomarkers and disease pathways. The multi-omics network provides a new molecular insight from a multi-molecular aspect and highlights dysregulated interactions. The highlighted let-7-AIFM1-FKBP1A pathway also indicates new hypotheses of COPD pathology.Peer reviewe

e-Reverse logistics for remanufacture-to-order : an online auction-based and multi- agent system supported solution

Due to the rapid obsolescent nature of consumer products, the remanufacture-to-stock strategy, in which remanufacturers tend to collect certain amount of end-of-life products, remanufacturing them as many as they can and keep these remanufactured products in stock waiting for customers come to buy, is not always an optimal solution. Under this circumstance, remanufacture-to-order policy, as an effective complement, provides a good trade-off for remanufacturers between meeting consumers’ demand and, in the meantime, keeping the inventory cost at a lower level. To remanufacture the used items, the manufacturer must retrieve them from the market where they are dispersed among consumers. This is accomplished by means of a reverse logistics chain that is comparable to the new product distribution system in reverse. However, the current reverse logistics do not respond to remanufacture-to-order at an efficient level. Therefore it is a necessity to develop a novel infrastructure, which can deal with these issues. This paper presents a framework called e-reverse logistics that aims at filling this gap. The major features and architecture of the proposed e-reverse logistics are detailed in this work

e-RL : the Internet of things supported reverse logistics for remanufacture-to-order

With the increasing globalization, there are many sources of uncertainty across the entire reverse logistics for end-of-life product recovery. Information sharing is a key ingredient in this respect because it helps to eradicate potential uncertainties related to various corporate behaviors, especially in remanufacture-to-order aspect. However traditional reverse logistics does not fully address itself to this issue. As a result, the progressive loss of product information as it moves through its lifecycle becomes inevitable which leads to a difficulty in implementing remanufacture-to-order strategy. Motivated by this fact, this study presents an ongoing design of novel reverse logistics (i.e., e-reverse logistics). The Internet of things technology is introduced into this framework for the purpose of keeping product life cycle information integrity. Furthermore, the cooperation and collaboration between actors involved in proposed architecture are treated in multi-agent system philosophy. The design characteristics and working principles of e-reverse logistics are detailed in this paper and it serves as a start point for further implementation

Crystal Structure Manipulation of the Exchange Bias in an Antiferromagnetic Film

Exchange bias is one of the most extensively studied phenomena in magnetism, since it exerts a unidirectional anisotropy to a ferromagnet (FM) when coupled to an antiferromagnet (AFM) and the control of the exchange bias is therefore very important for technological applications, such as magnetic random access memory and giant magnetoresistance sensors. In this letter, we report the crystal structure manipulation of the exchange bias in epitaxial hcp Cr2O3 films. By epitaxially growing twined (10-10) oriented Cr2O3 thin films, of which the c axis and spins of the Cr atoms lie in the film plane, we demonstrate that the exchange bias between Cr2O3 and an adjacent permalloy layer is tuned to in-plane from out-of-plane that has been observed in (0001) oriented Cr2O3 films. This is owing to the collinear exchange coupling between the spins of the Cr atoms and the adjacent FM layer. Such a highly anisotropic exchange bias phenomenon is not possible in polycrystalline films.Comment: To be published in Scientific Reports, 12 pages, 6 figure

Highly Enantioselective Synthesis of Heteroaromatic Alcohols Catalyzed by Chiral Diaminodiphosphine-Ruthenium(II) Complexes

Chiral diaminodiphosphine-ruthenium(II) complexes were found to be excellent catalysts for the asymmetric transfer hydrogenation of heteroatomic ketones in propan-2-ol. In the presence of potassium hydroxide, the enantioselective reduction of heteroaromatic ketones procceded smoothly to give chiral alcohols with excellent enantiomeric excess (up to 97% ee) under mild conditions without reduction of the heterocycle.National Natural Science Foundation of China [20423002, 20703034]; Natural Science Foundation of Fujian Province of China [2008J0235]; State Key Laboratory of Physical Chemistry of Solid Surface