62 research outputs found
Direct imaging of a massive dust cloud around R Coronae Borealis
We present recent polarimetric images of the highly variable star R CrB using
ExPo and archival WFPC2 images from the HST. We observed R CrB during its
current dramatic minimum where it decreased more than 9 mag due to the
formation of an obscuring dust cloud. Since the dust cloud is only in the
line-of-sight, it mimics a coronograph allowing the imaging of the star's
circumstellar environment. Our polarimetric observations surprisingly show
another scattering dust cloud at approximately 1.3" or 2000 AU from the star.
We find that to obtain a decrease in the stellar light of 9 mag and with 30% of
the light being reemitted at infrared wavelengths (from R CrB's SED) the grains
in R CrB's circumstellar environment must have a very low albedo of
approximately 0.07%. We show that the properties of the dust clouds formed
around R CrB are best fitted using a combination of two distinct populations of
grains size. The first are the extremely small 5 nm grains, formed in the low
density continuous wind, and the second population of large grains (~0.14
{\mu}m) which are found in the ejected dust clouds. The observed scattering
cloud, not only contains such large grains, but is exceptionally massive
compared to the average cloud.Comment: 8 pages, 7 figures published in A&
The type III effector EspF coordinates membrane trafficking by the spatiotemporal activation of two eukaryotic signaling pathways
Bacterial toxins and effector proteins hijack eukaryotic enzymes that are spatially localized and display rapid signaling kinetics. However, the molecular mechanisms by which virulence factors engage highly dynamic substrates in the host cell environment are poorly understood. Here, we demonstrate that the enteropathogenic Escherichia coli (EPEC) type III effector protein EspF nucleates a multiprotein signaling complex composed of eukaryotic sorting nexin 9 (SNX9) and neuronal Wiskott-Aldrich syndrome protein (N-WASP). We demonstrate that a specific and high affinity association between EspF and SNX9 induces membrane remodeling in host cells. These membrane-remodeling events are directly coupled to N-WASP/Arp2/3–mediated actin nucleation. In addition to providing a biochemical mechanism of EspF function, we find that EspF dynamically localizes to membrane-trafficking organelles in a spatiotemporal pattern that correlates with SNX9 and N-WASP activity in living cells. Thus, our findings suggest that the EspF-dependent assembly of SNX9 and N-WASP represents a novel form of signaling mimicry used to promote EPEC pathogenesis and gastrointestinal disease
Active, but not passive cigarette smoking was inversely associated with mammographic density
The opposing carcinogenic and antiestrogenic properties of tobacco smoke may explain why epidemiologic studies have not consistently reported positive associations for active smoking and breast cancer risk. A negative relation between mammographic density, a strong breast cancer risk factor, and active smoking would lend support for an antiestrogenic mechanism.
We used multivariable linear regression to assess the associations of active smoking and secondhand smoke (SHS) exposure with mammographic density in 799 pre- and early perimenopausal women in the Study of Women’s Health Across the Nation (SWAN).
We observed that current active smoking was associated with 7.2% lower mammographic density, compared to never active smoking and no SHS exposure (p = 0.02). Starting to smoke before 18 years of age and having smoked ≥20 cigarettes/day were also associated with statistically significantly lower percent densities. Among nulliparous women having smoked ≥20 cigarettes/day was associated with 23.8% lower density, compared to having smoked ≤9 cigarettes/day (p < 0.001).
Our findings support the hypothesis that tobacco smoke exerts an antiestrogenic effect on breast tissue, but counters the known increased risk of breast cancer with smoking prior to first full-term birth. Thus, our data suggest that the antiestrogenic but not the carcinogenic effects of smoking may be reflected by breast density
The James Webb Space Telescope Mission
Twenty-six years ago a small committee report, building on earlier studies,
expounded a compelling and poetic vision for the future of astronomy, calling
for an infrared-optimized space telescope with an aperture of at least .
With the support of their governments in the US, Europe, and Canada, 20,000
people realized that vision as the James Webb Space Telescope. A
generation of astronomers will celebrate their accomplishments for the life of
the mission, potentially as long as 20 years, and beyond. This report and the
scientific discoveries that follow are extended thank-you notes to the 20,000
team members. The telescope is working perfectly, with much better image
quality than expected. In this and accompanying papers, we give a brief
history, describe the observatory, outline its objectives and current observing
program, and discuss the inventions and people who made it possible. We cite
detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space
Telescope Overview, 29 pages, 4 figure
213 The Effect of Enteropathogenic E. coli EspG1/2-mediated Microtubule Disruption on Intestinal Epithelial Tight Junction Regulation and Recovery
Mo1946 Interaction of EPEC EspF With 14-3-3 Drives the Redistribution of the Polarity Protein Par1b Leading to Disruption of Epithelial Tight Junctions
ATYPICAL ENTEROPATHOGENIC E. COLI (EPEC) ISOLATES FROM DIARRHEAL SAMPLES WITH HIGH EPEC LOADS HAVE INCREASED AND PREFERENTIAL ADHESION TO COLONIC VERSUS SMALL INTESTINAL EPITHELIAL CELLS
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