Newly identified compact hierarchical triple system candidates using Gaia DR3

Aims. We introduce a novel way to identify new compact hierarchical triple stars by exploiting the huge potential of Gaia DR3 and also its future data releases. We aim to increase the current number of compact hierarchical triples significantly. Methods. We utilize several eclipsing binary catalogs from different sky surveys totaling more than 1 million targets for which we search for Gaia DR3 Non-single Star orbital solutions with periods substantially longer than the eclipsing periods of the binaries. Those solutions in most cases should belong to outer orbits of tertiary stars in those systems. We also try to validate some of our best-suited candidates using TESS eclipse timing variations. Results. We find 403 objects with suitable Gaia orbital solutions of which 27 are already known triple systems. This makes 376 newly identified hierarchical triple system candidates in our sample. We analyze the cumulative probability distribution of the outer orbit eccentricities and find that it is very similar to the ones found by earlier studies based on the observations of the Kepler and OGLE missions. We found measurable non-linear eclipse timing variations or third-body eclipses in the TESS data for 192 objects which we also consider to be confirmed candidates. Out of these, we construct analytical light-travel time effect models for the eclipse timing variations of 22 objects with well-sampled TESS observations. We compare the outer orbital parameters from our solutions with the ones from the Gaia solutions and find that the most reliable orbital parameter is the orbital period, while the values of the other parameters should be used with caution.Comment: 18 pages, 9 figures, 6 tables, Accepted for publication in Astronomy & Astrophysic

Planet Hunters: New Kepler planet candidates from analysis of quarter 2

We present new planet candidates identified in NASA Kepler quarter two public release data by volunteers engaged in the Planet Hunters citizen science project. The two candidates presented here survive checks for false-positives, including examination of the pixel offset to constrain the possibility of a background eclipsing binary. The orbital periods of the planet candidates are 97.46 days (KIC 4552729) and 284.03 (KIC 10005758) days and the modeled planet radii are 5.3 and 3.8 R_Earth. The latter star has an additional known planet candidate with a radius of 5.05 R_Earth and a period of 134.49 which was detected by the Kepler pipeline. The discovery of these candidates illustrates the value of massively distributed volunteer review of the Kepler database to recover candidates which were otherwise uncatalogued.Comment: Accepted to A

Planet Hunters X: Searching for Nearby Neighbors of 75 Planet and Eclipsing Binary Candidates from the K2 Kepler Extended Mission

We present high-resolution observations of a sample of 75 K2 targets from Campaigns 1-3 using speckle interferometry on the Southern Astrophysical Research (SOAR) telescope and adaptive optics (AO) imaging at the Keck II telescope. The median SOAR $I$-band and Keck $K_s$-band detection limits at 1" were $\Delta m_{I}=4.4$~mag and $\Delta m_{K_s}=6.1$~mag, respectively. This sample includes 37 stars likely to host planets, 32 targets likely to be eclipsing binaries (EBs), and 6 other targets previously labeled as likely planetary false positives. We find nine likely physically bound companion stars within 3" of three candidate transiting exoplanet host stars and six likely EBs. Six of the nine detected companions are new discoveries; one of the six, EPIC 206061524, is associated with a planet candidate. Among the EB candidates, companions were only found near the shortest period ones ($P<3$ days), which is in line with previous results showing high multiplicity near short-period binary stars. This high-resolution data, including both the detected companions and the limits on potential unseen companions, will be useful in future planet vetting and stellar multiplicity rate studies for planets and binaries.Comment: Accepted in A

Planet Hunters. VIII. Characterization of 41 Long-Period Exoplanet Candidates from Kepler Archival Data

The census of exoplanets is incomplete for orbital distances larger than 1 AU. Here, we present 41 long-period planet candidates in 38 systems identified by Planet Hunters based on Kepler archival data (Q0-Q17). Among them, 17 exhibit only one transit, 14 have two visible transits and 10 have more than three visible transits. For planet candidates with only one visible transit, we estimate their orbital periods based on transit duration and host star properties. The majority of the planet candidates in this work (75%) have orbital periods that correspond to distances of 1-3 AU from their host stars. We conduct follow-up imaging and spectroscopic observations to validate and characterize planet host stars. In total, we obtain adaptive optics images for 33 stars to search for possible blending sources. Six stars have stellar companions within 4". We obtain high-resolution spectra for 6 stars to determine their physical properties. Stellar properties for other stars are obtained from the NASA Exoplanet Archive and the Kepler Stellar Catalog by Huber et al. (2014). We validate 7 planet candidates that have planet confidence over 0.997 (3-{\sigma} level). These validated planets include 3 single-transit planets (KIC-3558849b, KIC-5951458b, and KIC-8540376c), 3 planets with double transits (KIC-8540376b, KIC-9663113b, and KIC-10525077b), and 1 planet with 4 transits (KIC-5437945b). This work provides assessment regarding the existence of planets at wide separations and the associated false positive rate for transiting observation (17%-33%). More than half of the long-period planets with at least three transits in this paper exhibit transit timing variations up to 41 hours, which suggest additional components that dynamically interact with the transiting planet candidates. The nature of these components can be determined by follow-up radial velocity and transit observations.Comment: Published on ApJ, 815, 127 Notations of validated planets are changed in accordance with naming convention of NASA Exoplanet Archiv

A Population of Dipper Stars from the Transiting Exoplanet Survey Satellite Mission

Dipper stars are a classification of young stellar objects that exhibit dimming variability in their light curves, dropping in brightness by 10-50%, likely induced by occultations due to circumstellar disk material. This variability can be periodic, quasi-periodic, or aperiodic. Dipper stars have been discovered in young stellar associations via ground-based and space-based photometric surveys. We present the detection and characterization of the largest collection of dipper stars to date: 293 dipper stars, including 234 new dipper candidates. We have produced a catalog of these targets, which also includes young stellar variables that exhibit predominately bursting-like variability and symmetric variability (equal parts bursting and dipping). The total number of catalog sources is 414. These variable sources were found in a visual survey of TESS light curves, where dipping-like variability was observed. We found a typical age among our dipper sources of <5 Myr, with the age distribution peaking at ~2 Myr, and a tail of the distribution extending to ages older than 20 Myr. Regardless of the age, our dipper candidates tend to exhibit infrared excess, which is indicative of the presence of disks. TESS is now observing the ecliptic plane, which is rich in young stellar associations, so we anticipate many more discoveries in the TESS dataset. A larger sample of dipper stars would enhance the census statistics of light curve morphologies and dipper ages.Comment: 19 pages, 11 figures, 1 table (included in latex source), accepted for publication in ApJ

BU Canis Minoris -- the Most Compact Known Flat Doubly Eclipsing Quadruple System

We have found that the 2+2 quadruple star system BU CMi is currently the most compact quadruple system known, with an extremely short outer period of only 121 days. The previous record holder was TIC 219006972 (Kostov et al. 2023), with a period of 168 days. The quadruple nature of BU CMi was established by Volkov et al. (2021), but they misidentified the outer period as 6.6 years. BU CMi contains two eclipsing binaries (EBs), each with a period near 3 days, and a substantial eccentricity of about 0.22. All four stars are within about 0.1 solar mass of 2.4 solar masses. Both binaries exhibit dynamically driven apsidal motion with fairly short apsidal periods of about 30 years, thanks to the short outer orbital period. The outer period of 121 days is found both from the dynamical perturbations, with this period imprinted on the eclipse timing variations (ETV) curve of each EB by the other binary, and by modeling the complex line profiles in a collection of spectra. We find that the three orbital planes are all mutually aligned to within 1 degree, but the overall system has an inclination angle near 83.5 degrees. We utilize a complex spectro-photodynamical analysis to compute and tabulate all the interesting stellar and orbital parameters of the system. Finally, we also find an unexpected dynamical perturbation on a timescale of several years whose origin we explore. This latter effect was misinterpreted by Volkov et al. (2021) and led them to conclude that the outer period was 6.6 years rather than the 121 days that we establish here.Comment: 19 pages, 8 pages, accepted to MNRA

The PTTG1-binding factor (PBF/PTTG1IP) regulates p53 activity in thyroid cells

The PTTG1-Binding Factor (PBF/PTTG1IP) has an emerging repertoire of roles, especially in thyroid biology, and functions as a proto-oncogene. High PBF expression is independently associated with poor prognosis and lower disease-specific survival in human thyroid cancer. However, the precise role of PBF in thyroid tumorigenesis is unclear. Here, we present extensive evidence demonstrating that PBF is a novel regulator of p53, a tumor suppressor protein with a key role in maintaining genetic stability, which is infrequently mutated in differentiated thyroid cancer. By coimmunoprecipitation and proximity ligation assays, we show that PBF binds specifically to p53 in thyroid cells, and significantly represses transactivation of responsive promoters. Further, we identify that PBF decreases p53 stability by enhancing ubiquitination, which appears dependent on the E3 ligase activity of Mdm2. Impaired p53 function was evident in a transgenic mouse model with thyroid-specific PBF over-expression (PBF-Tg), which had significantly increased genetic instability as indicated by FISSR-PCR analysis. Consistent with this, ~40% of all DNA repair genes examined were repressed in PBF-Tg primary cultures, including genes with critical roles in maintaining genomic integrity such as Mgmt, Rad51 and Xrcc3. Our data also revealed that PBF induction resulted in upregulation of the E2 enzyme Rad6 in murine thyrocytes, and was associated with Rad6 expression in human thyroid tumors. Overall, this work provides novel insights into the role of the proto-oncogene PBF as a negative regulator of p53 function in thyroid tumorigenesis, where PBF is generally over-expressed and p53 mutations are rare compared to other tumor types

Long- and short-term outcomes in renal allografts with deceased donors: A large recipient and donor genome-wide association study.

Improvements in immunosuppression have modified short-term survival of deceased-donor allografts, but not their rate of long-term failure. Mismatches between donor and recipient HLA play an important role in the acute and chronic allogeneic immune response against the graft. Perfect matching at clinically relevant HLA loci does not obviate the need for immunosuppression, suggesting that additional genetic variation plays a critical role in both short- and long-term graft outcomes. By combining patient data and samples from supranational cohorts across the United Kingdom and European Union, we performed the first large-scale genome-wide association study analyzing both donor and recipient DNA in 2094 complete renal transplant-pairs with replication in 5866 complete pairs. We studied deceased-donor grafts allocated on the basis of preferential HLA matching, which provided some control for HLA genetic effects. No strong donor or recipient genetic effects contributing to long- or short-term allograft survival were found outside the HLA region. We discuss the implications for future research and clinical application