The Flexible Group Spatial Keyword Query

We present a new class of service for location based social networks, called the Flexible Group Spatial Keyword Query, which enables a group of users to collectively find a point of interest (POI) that optimizes an aggregate cost function combining both spatial distances and keyword similarities. In addition, our query service allows users to consider the tradeoffs between obtaining a sub-optimal solution for the entire group and obtaining an optimimized solution but only for a subgroup. We propose algorithms to process three variants of the query: (i) the group nearest neighbor with keywords query, which finds a POI that optimizes the aggregate cost function for the whole group of size n, (ii) the subgroup nearest neighbor with keywords query, which finds the optimal subgroup and a POI that optimizes the aggregate cost function for a given subgroup size m (m <= n), and (iii) the multiple subgroup nearest neighbor with keywords query, which finds optimal subgroups and corresponding POIs for each of the subgroup sizes in the range [m, n]. We design query processing algorithms based on branch-and-bound and best-first paradigms. Finally, we provide theoretical bounds and conduct extensive experiments with two real datasets which verify the effectiveness and efficiency of the proposed algorithms.Comment: 12 page

Sols favorables à la cacaoculture au centre-ouest de la Côte d’Ivoire dans un contexte d’assèchement climatique

En Afrique de l&#8217;Ouest en g&#233;n&#233;ral et particuli&#232;rement en C&#244;te d&#8217;Ivoire, la survie des jeunes cacaoyers, pendant la phase de replantation, d&#233;pend en grande partie de leur alimentation hydrique, soit &#224; partir des pluies, soit &#224; partir de la r&#233;serve en eau des sols. Or, depuis ces derni&#232;res d&#233;cennies, le d&#233;ficit pluviom&#233;trique va grandissant. En effet, les hauteurs pluviom&#233;triques sont en baisse et la r&#233;partition des pluies est irr&#233;guli&#232;re. Pour combler le d&#233;ficit pluviom&#233;trique, le sol doit disposer d&#8217;une importante r&#233;serve en eau. Pour se faire, il doit &#234;tre d&#233;pourvu de toutes contraintes morpho-p&#233;dologiques pouvant r&#233;duire sa capacit&#233; de r&#233;tention en eau. Le choix de ce type de sol n&#8217;est pas du tout ais&#233; pour les producteurs non initi&#233;s &#224; l&#8217;&#233;tude p&#233;dologique. Une &#233;tude morpho-p&#233;dologique a donc &#233;t&#233; entreprise dans le Centre-Ouest de la C&#244;te d&#8217;Ivoire, le long de 30 paysages morpho-p&#233;dologiques repr&#233;sentatifs. Elle a permis d&#8217;identifier et localier &#224; travers une Analyse en Composantes Principales (ACP), les contraintes morphologiques &#224; la cacaoculture. En outre, les sols morphologiquement favorables aux cacaoyers situ&#233;s sur les mi-versants et les bas de versant des paysages morpho-p&#233;dologiques.Mots cl&#233;s: replantation cacaoy&#232;re, m&#233;thode morpho-p&#233;dologique, segment topographique, sols favorables au cacaoye

Delayed diagnosis of Townes‑Brocks syndrome with multicystic kidneys and renal failure caused by a novel SALL1 nonsense mutation: A case report

Townes‑Brocks syndrome (TBS) is a rare autosomal dominant congenital anomaly syndrome characterized by the triad of anorectal, hand and external ear malformations. Kidney involvement is less common and may progress to end‑stage renal failure (ESRF) early in life. The present study reports the case of a male patient presenting with multiple bilateral cortical kidney cysts at the age of 4 years, at which time the kidneys were of normal size and function. A clinical diagnosis of autosomal recessive polycystic kidney disease was made initially as the patient's parents are clinically healthy. However, the consideration of extra‑renal involvements (imperforate anus at birth, preaxial polydactyly and dysplastic right ear) following the progression of the patient to ESRF at the age of 16 years, led to the diagnosis of TBS. This prompted sequencing of the SALL1 gene, which identified a novel heterozygous nonsense mutation in the mutational ‘hotspot’ of exon 2 (c.874C>T, p.Q292X), and this mutation was not detected in healthy controls. The current case highlights that TBS may present with normal sized, cystic kidneys in childhood, while recognition of extra‑renal features of cystic kidney diseases, such as TBS, and genetic testing may facilitate the correct diagnosis and transmission mode. Reaching a correct diagnosis of as TBS is important since this condition has a 50% rate of transmission to offspring and can progress to ESRF early in life

Comparaison de deux techniques de replantation cacaoyère sur antécédents culturaux non-forestiers en Côte d’Ivoire

Le verger de cacaoyers de la Côte d’Ivoire, premier producteur mondial de cacao, est vieillissant et doit être régénéré pour assurer une production durable de cacao. Mais, les réserves de forêt utilisées autrefois pour l’extension des plantations sont épuisées. Les terres cultivables disponibles sont les jachères et les cacaoyères dégradées. Malheureusement, la plupart des tentatives de plantation sur ces antécédents culturaux dégradés échouent. En vue de proposer aux producteurs des itinéraires techniques adaptés, deux techniques de replantation ont été comparées sur 40 parcelles replantées dont 20 après des vieux cacaoyers âgés de plus de 30 ans avec moins de 700 arbres ha-1 et 20 autres après des jachères de durée inférieure à 10 ans. Ces parcelles ont été installées entre 2004 et 2006 dans 10 régions productrices de cacao. Les résultats ont montré que la replantation sous vieux cacaoyers est plus efficace. L’efficacité de cette technique est liée à la fertilité des sols relativement meilleure et au niveau d’enherbement plus faible sous les vieux cacaoyers par rapport aux jachères. Il est cependant nécessaire de bien gérer l’ombrage des vieux cacaoyers, en effectuant des éclaircies avant 6 et 24 mois après la mise en place des jeunes cacaoyers.Mots Clés: Cacao, itinéraires techniques, jachère, régénérationEnglish AbstractCocoa farms of Côte d’Ivoire, the world’s largest cocoa producer, are getting older and must be regenerated for sustainable cocoa production. However, forest reserves formerly used for the expansion of plantations are finished. Available cultivable land parcels are fallows with poor soil and degraded cocoa farms. Unfortunately, most attempts of replanting on these poor lands fail. In order to provide producers with appropriate replanting techniques, two replanting techniques were compared on a 40 replanted plots, including 20 plots after more than 30 years-old cocoa farms with less than 700 trees ha-1 and 20 other plots after fallows of less than 10 years. These plots were installed between 2004 and 2006 in 10 cocoa producing areas. Replanting under the old cocoa trees is more effective. The effectiveness of this practice is related to the relatively better soil fertility and lower level of the weeds proliferation under the old cocoa trees as compared to the fallows. It is, however, necessary to reduce the shade of the old cocoa trees before 6 and 24 months after the establishment of the young cocoa trees.Keywords: Cocoa, fallow, previous land, regeneratio

Classifying and Grouping Mammography Images into Communities Using Fisher Information Networks to Assist the Diagnosis of Breast Cancer

© 2020, Springer Nature Switzerland AG. The aim of this paper is to build a computer based clinical decision support tool using a semi-supervised framework, the Fisher Information Network (FIN), for visualization of a set of mammographic images. The FIN organizes the images into a similarity network from which, for any new image, reference images that are closely related can be identified. This enables clinicians to review not just the reference images but also ancillary information e.g. about response to therapy. The Fisher information metric defines a Riemannian space where distances reflect similarity with respect to a given probability distribution. This metric is informed about generative properties of data, and hence assesses the importance of directions in space of parameters. It automatically performs feature relevance detection. This approach focusses on the interpretability of the model from the standpoint of the clinical user. Model predictions were validated using the prevalence of classes in each of the clusters identified by the FIN

MSSM Baryogenesis and Electric Dipole Moments: An Update on the Phenomenology

We explore the implications of electroweak baryogenesis for future searches for permanent electric dipole moments in the context of the minimal supersymmetric extension of the Standard Model (MSSM). From a cosmological standpoint, we point out that regions of parameter space that over-produce relic lightest supersymmetric particles can be salvaged only by assuming a dilution of the particle relic density that makes it compatible with the dark matter density: this dilution must occur after dark matter freeze-out, which ordinarily takes place after electroweak baryogenesis, implying the same degree of dilution for the generated baryon number density as well. We expand on previous studies on the viable MSSM regions for baryogenesis, exploring for the first time an orthogonal slice of the relevant parameter space, namely the (tan\beta, m_A) plane, and the case of non-universal relative gaugino-higgsino CP violating phases. The main result of our study is that in all cases lower limits on the size of the electric dipole moments exist, and are typically on the same order, or above, the expected sensitivity of the next generation of experimental searches, implying that MSSM electroweak baryogenesis will be soon conclusively tested.Comment: 23 pages, 10 figures, matches version published in JHE

TGF-beta 1 induces human alveolar epithelial to mesenchymal cell transition (EMT)

Background: Fibroblastic foci are characteristic features in lung parenchyma of patients with idiopathic pulmonary fibrosis (IPF). They comprise aggregates of mesenchymal cells which underlie sites of unresolved epithelial injury and are associated with progression of fibrosis. However, the cellular origins of these mesenchymal phenotypes remain unclear. We examined whether the potent fibrogenic cytokine TGF-β1 could induce epithelial mesenchymal transition (EMT) in the human alveolar epithelial cell line, A549, and investigated the signaling pathway of TGF-β1-mediated EMT. Methods: A549 cells were examined for evidence of EMT after treatment with TGF-β1. EMT was assessed by: morphology under phase-contrast microscopy; Western analysis of cell lysates for expression of mesenchymal phenotypic markers including fibronectin EDA (Fn-EDA), and expression of epithelial phenotypic markers including E-cadherin (E-cad). Markers of fibrogenesis, including collagens and connective tissue growth factor (CTGF) were also evaluated by measuring mRNA level using RT-PCR, and protein by immunofluorescence or Western blotting. Signaling pathways for EMT were characterized by Western analysis of cell lysates using monoclonal antibodies to detect phosphorylated Erk1/2 and Smad2 after TGF-β1 treatment in the presence or absence of MEK inhibitors. The role of Smad2 in TGF-β1-mediated EMT was investigated using siRNA. Results: The data showed that TGF-β1, but not TNF-α or IL-1β, induced A549 cells with an alveolar epithelial type II cell phenotype to undergo EMT in a time-and concentration-dependent manner. The process of EMT was accompanied by morphological alteration and expression of the fibroblast phenotypic markers Fn-EDA and vimentin, concomitant with a downregulation of the epithelial phenotype marker E-cad. Furthermore, cells that had undergone EMT showed enhanced expression of markers of fibrogenesis including collagens type I and III and CTGF. MMP-2 expression was also evidenced. TGF-β1-induced EMT occurred through phosphorylation of Smad2 and was inhibited by Smad2 gene silencing; MEK inhibitors failed to attenuate either EMT-associated Smad2 phosphorylation or the observed phenotypic changes. Conclusion: Our study shows that TGF-β1 induces A549 alveolar epithelial cells to undergo EMT via Smad2 activation. Our data support the concept of EMT in lung epithelial cells, and suggest the need for further studies to investigate the phenomenon

Ferritins: furnishing proteins with iron

Ferritins are a superfamily of iron oxidation, storage and mineralization proteins found throughout the animal, plant, and microbial kingdoms. The majority of ferritins consist of 24 subunits that individually fold into 4-α-helix bundles and assemble in a highly symmetric manner to form an approximately spherical protein coat around a central cavity into which an iron-containing mineral can be formed. Channels through the coat at inter-subunit contact points facilitate passage of iron ions to and from the central cavity, and intrasubunit catalytic sites, called ferroxidase centers, drive Fe2+ oxidation and O2 reduction. Though the different members of the superfamily share a common structure, there is often little amino acid sequence identity between them. Even where there is a high degree of sequence identity between two ferritins there can be major differences in how the proteins handle iron. In this review we describe some of the important structural features of ferritins and their mineralized iron cores and examine in detail how three selected ferritins oxidise Fe2+ in order to explore the mechanistic variations that exist amongst ferritins. We suggest that the mechanistic differences reflect differing evolutionary pressures on amino acid sequences, and that these differing pressures are a consequence of different primary functions for different ferritins

Human α2β1HI CD133+VE epithelial prostate stem cells express low levels of active androgen receptor

Stem cells are thought to be the cell of origin in malignant transformation in many tissues, but their role in human prostate carcinogenesis continues to be debated. One of the conflicts with this model is that cancer stem cells have been described to lack androgen receptor (AR) expression, which is of established importance in prostate cancer initiation and progression. We re-examined the expression patterns of AR within adult prostate epithelial differentiation using an optimised sensitive and specific approach examining transcript, protein and AR regulated gene expression. Highly enriched populations were isolated consisting of stem (α(2)β(1)(HI) CD133(+VE)), transiently amplifying (α(2)β(1)(HI) CD133(-VE)) and terminally differentiated (α(2)β(1)(LOW) CD133(-VE)) cells. AR transcript and protein expression was confirmed in α(2)β(1)(HI) CD133(+VE) and CD133(-VE) progenitor cells. Flow cytometry confirmed that median (±SD) fraction of cells expressing AR were 77% (±6%) in α(2)β(1)(HI) CD133(+VE) stem cells and 68% (±12%) in α(2)β(1)(HI) CD133(-VE) transiently amplifying cells. However, 3-fold lower levels of total AR protein expression (peak and median immunofluorescence) were present in α(2)β(1)(HI) CD133(+VE) stem cells compared with differentiated cells. This finding was confirmed with dual immunostaining of prostate sections for AR and CD133, which again demonstrated low levels of AR within basal CD133(+VE) cells. Activity of the AR was confirmed in prostate progenitor cells by the expression of low levels of the AR regulated genes PSA, KLK2 and TMPRSS2. The confirmation of AR expression in prostate progenitor cells allows integration of the cancer stem cell theory with the established models of prostate cancer initiation based on a functional AR. Further study of specific AR functions in prostate stem and differentiated cells may highlight novel mechanisms of prostate homeostasis and insights into tumourigenesis