THE FISHER INFORMATION MATRIX IN DOUBLY CENSORED DATA FROM THE DAGUM DISTRIBUTION

In this note, we provide the mathematical tools for computing the entries of the Fisher information matrix in case of the observations are doubly censored from a Dagum distribution.Order Statistics, Maximum Likelihood Estimator, Fisher Information Matrix

The Fisher Information Matrix in Right Censored Data from the Dagum Distribution

In this note, we provide the mathematical details of the calculation of the Fisher information matrix when the data involve type I right censored observations from a Dagum distribution.Fisher information matrix, type I right censored observations, Dagum distribution

Biomolecule recognition using piezoresistive nanomechanical force probes

Highly sensitive sensors are one of the enabling technologies for the biomarker detection in early stage diagnosis of pathologies. We have developed a self-sensing nanomechanical force probe able for detecting the unbinding of single couples of biomolecular partners in nearly physiological conditions. The embedding of a piezoresistive transducer into a nanomechanical cantilever enabled high force measurement capability with sub 10-pN resolution. Here, we present the design, microfabrication, optimization, and complete characterization of the sensor. The exceptional electromechanical performance obtained allowed us to detect biorecognition specific events underlying the biotin-avidin complex formation, by integrating the sensor in a commercial atomic force microscope.This work has been supported by the Spanish Ministry of Science and Innovation through projects NANOSELECT-CSD2007-00041(Consolider-Ingenio 2010) and TEC2011-23600, by the European Union through the COST ACTION TD1002 and partly supported by the PRIN-MIUR Project No. 2009 WPZM4S and by AIRC (Grant IG10412.)Peer reviewe