Training to translate: Understanding and informing translational animal research in pre-clinical pharmacology

This is the final version. Available on open access from Tecnoscienza via the link in this recordWe investigate translation in biomedicine by exploring how researchers supported by the British Pharmacological Society’s Integrative Pharmacology Fund (IPF) have responded to increasing translational aspirations within pre-clinical animal research. The IPF sought to enhance institutional capacities, collaborative practices, and personal skills within in vivo research in the quintessentially translational fields of pharmacology, physiology and toxicology. We identify three manifestations of the influence of translational aspirations: 1) shifting from the standardisation of animal models to the alignment of research on animals with human therapeutic pathways; 2) expanding relationalities of care in animal research from a focus on the animal body to institutional arrangements around clinical care; and 3) changing training around research ethics, integrity and good statistical practice. Concluding, we discuss the value of working interactively with those involved in the changing practices of animal research and translation as a means to foster reflexivity about what matters when ‘training to translate’.British Pharmacological SocietyWellcome TrustEuropean Research CouncilAustralian Research Counci

Frontal Polymerization and Geopolymerization, the First Example: Organic-Inorganic Hybrid Materials

This work shows the first example of frontal geopolymerization, obtained in the same reactor in which the frontal polymerization of 1,6 hexanediolodiaacrylate occurs at the same time; the simultaneous frontal polymerization allows to obtain an organic-inorganic hybrid material in a single step and in a short time (a few minutes), thanks to the exothermicity of the two reactions which are mutually self-supporting. This technique represents the only way to obtain hybrid organic polymer-geopolymer mate-rials: using the classical polymerization (prolonged heating) the reaction is explosive due to the formation of gaseous products, while the polymerization at room temperature, due to the very long times, leads to a phase separation

Recycling of Waste Corundum Abrasive Powder in Mk-Based Geopolymers

Recycling corundum abrasive powder in metakaolin-based geopolymer formulations is proposed to reduce the amount of waste to be treated or disposed of in landfills, allowing to decrease ecological damage as well as to reduce transport costs for removal. The addition of waste corundum, as an important source of Al2O3, has proved to increase the slightly ionic conductivity of the leachate solution obtained after immersion in water of samples at 28 d of curing at room temperature. With the same curing conditions, the geopolymerization process has not been disturbed as evidenced by the FT-IR peak shift and XRD patterns. It was recorded a decrease in resistance to compression of the consolidated geopolymers of about 5% with 10 wt% addition and of about 77% with the addition of 20 wt% of waste corundum. In any case, the waste abrasive powder does not release heavy metals when added to a geopolymeric formulation based on MK, NaOH, and Na-silicate, and does not show relevant antibacterial properties, indicating the formation of a stable and safe final product with a ceramic-like appearance

Thermal Influence on Physico-Chemical Properties of Geopolymers Based on Metakaolin and Red Tomato Waste

The high amount of organic and inorganic wastes has increased the attention to new strategies aiming to reduce the waste disposals. Organic wastes, such as tomato wastes (TWs), are a good source from which the red color can be obtained. Among the different technologies, the geopolymers had been proposed as a powerful technology able to incorporate various kinds of wastes. In this paper, pure metakaolin and a mixture obtained by adding 10% of red TW-derived (peels) are consolidated by alkali activation at room temperature, 40 and 60°C without the pigment extraction. Fourier-transform infrared (FTIR) spectra confirmed the geopolymerization occurrences. Moreover, the obtained materials are analyzed for their conductivity and pH after the sample extractions at different times. The integrity tests assessed the resistance of the synthesized geopolymers and the presence of red tomato-wastes led to a release of yellow organic hydro-soluble compounds. Finally, the weight loss confirmed the integrity test. Indeed, there are no differences at 16 and 30 d

Thermal influence on physico-chemical properties of metakaolin/organic-based geopolymers

Abstract. The high amount of organic and inorganic wastes has increased the attention to new strategies aiming to reduce the waste disposals. Among the different technologies, the geopolymers had been proposed as a powerful technology able to incorporate various kind of wastes [1]. Pure metakaolin and a mixture obtained by adding 10% of tomato waste-derived were consolidated by alkali activation at room temperature, 40 and 60°C. FT-IR spectra confirmed the geopolymerization occurrences. Conductivity and pH were evaluated at different time. The integrity tests assessed the resistance of the synthesized geopolymers and the presence of tomato-wastes led to a release of yellow organic hydro-soluble compound. Weight loss confirmed the integrity test, indeed there were no differences at 16 and 30 days. Finally, the antibacterial properties of the synthesized geopolymers were investigated [2]. References [1] H.K. Tchakouté, C.H. Rüscher, S. Kong, E. Kamseu, C. Leonelli, Constr Build Mater. 2016, 114, 276 – 289 [2] G. Dal Poggetto, M. Catauro, G. Crescente, C. Leonelli, Polymer. 2021, 13, 149

Influence of the Addition of Waste Glass and Microbiological Performance of Metakaolin-Based Geopolymers Cement

Glass recycling reduces the amount of waste to be treated or disposed in landfills, allowing both to limit environmental damage and to save on the costs of transportation and disposal of waste. In this paper, an advantageous method for recycling glass containers (bottles, jars, jars for food, glasses, and cans for drinks, etc.) is presented. The glass is crushed and without being washed or separated from any foreign bodies it is safely incorporated into a metakaolin (MK)-based geopolymeric matrix. Pure MK and mixtures obtained by adding different percentages (30–50 wt%) of glass cullet are consolidated via alkali activation at 50°C. Infrared spectroscopy is able to reveal the formation of bonds in the mixtures between the geopolymeric matrix and the glass. Leaching tests are carried out to evaluate the eventual release of toxic metals, while the antibacterial tests complete the environmental evaluation of the final consolidated products that show how the mechanical performance are modified by adding different amount of glass cullet

Influence of the addition of waste glass and microbiological performance of metakaolin-based geopolymers cement

Abstract. Glass recycling reduces the amount of waste to be treated or disposed in landfills, allowing both to limit environmental damage and to save on the costs of transportation and disposal of waste. In this paper, an advantageous method for recycling glass containers (bottles, jars, jars for food, glasses and cans for drinks, etc.) is presented. The glass was crushed and without being washed or separated from any foreign bodies it was safely incorporated into a metakaolin-based geopolymeric matrix. Pure metakaolin and mixtures obtained by adding different percentages (30-50 wt%) of glass cullet were consolidated via alkali activation at 50°C. Infrared spectroscopy was able to reveal the formation of bonds in the mixtures between the geopolymeric matrix and the glass. Leaching tests were carried out to evaluate the eventual release of toxic metals, while the antibacterial tests completed the environmental evaluation of the final consolidated products that showed how the mechanical performance were modified by adding different amount of glass [1]. References [1] G. Dal Poggetto, M. Catauro, G. Crescente and C. Leonelli. Efficient addiction of waste glass in MK-based geopolymers: microstructure, antibacterial and cytotoxicity investigation. Polymers, 2021, 13, 1493

Tree-ring–based summer mean temperature variations in the Adamello–Presanella Group (Italian Central Alps), 1610–2008 AD

Abstract. Climate records from remote mountain sites and for century-long periods are usually lacking for most continents and also for the European Alps. However, detailed reconstructions of climate parameters for pre-instrumental periods in mountain areas, suffering of glacial retreat caused by recent global warming, are needed in the view of a better comprehension of the environmental dynamics. We present here the first annually-resolved reconstruction of summer (JJA) mean temperature for the Adamello–Presanella Group (Central European Alps), one of the most glaciated mountain groups of the Italian Central Alps. The reconstruction has been based on four larch tree-ring width chronologies derived from living trees sampled in four valleys surrounding the Group. The reconstruction spans from 1610 to 2008 and the statistical verification of the reconstruction demonstrates the positive skill of the tree-ring dataset in tracking summer temperature variability also in the recent period

Istiocitoma fibroso maligno mediastino-polmonare. Aspetti clinici, istiopatologici, terapeutici. Contributo casistico

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