Experimental and theoretical ınvestigation of pumpkin drying in fluidized bed dryer

Bu çalışmada balkabağının akışkan yataklı kurutucuda kurutma karakteristiği incelenmiştir. Deneyler için balkabağı tarla hasadından sonra küp şeklinde kesilerek, 50, 60 ve 70 °C’deki üç farklı sıcaklıktaki hava ile akışkan yataklı kurutucuda kurutulmuştur. Kurutulan balkabağının başlangıç nemi ıslak bazda %95 (kuru bazda %1930) mertebelerinde olup akışkanlaşma hızı 3,5 m/s seçilmiştir. Deney sonuçlarından, akışkan yataklı kurutucuda oldukça yüksek kuruma hızlarına ulaşıldığı ve böylece kuruma sürelerinin klasik yöntemlere ve sabit yataklı kurutuculara göre çok kısa sürelere indiği görülmüştür. Kurutma deneylerimizde en fazla 120 dakika sonunda %6’dan düşük bal kabağı nemlerine ulaşmak mümkün olmuştur. Bal kabağı kurutmanın matematiksel modellenmesi için literatürde sıkça kullanılan yarı-teorik modellerden Lewis modeli, Henderson ve Pabis modeli, Page modeli ve logaritmik ince tabaka kurutma modelleri seçilmiştir. Bunun yanında Fick’in birinci yasası olan kurutma teorik modeli ile de kurutma karakteristiği incelenmiştir. Bu modelde hesaplanan etkin difüzyon katsayılarının sonuçları, literatürdeki değerleri ile karşılaştırılmıştır. Akışkan yataklı kurutucuda hesaplanan etkin difüzyon katsayıları, sabit yataklı kurutuculara göre %70’lere varan daha yüksek değerlere ulaşmıştır. Bunun yanında etkin difüzyon katsayılarının sıcaklığa bağımlılıkları Arrhenius denklemi ile açıklanmıştır.Thin layer drying characteristics of pumpkin cube were experimentally investigated in a fluidized bed dryer. Experiments were performed at three different drying temperatures: 50, 60 and 70 °C. Pumpkin used in the experiments had an initial moisture content of 95% wet basis (1930 % dry basis). The drying air velocities were set to 3.5 m/s to achieve fluidization. Experimental results show that large drying rates are obtained in the fluidized bed dryer, which are much higher than those obtained with conventional methods and convective tray dryer. In just 120 minutes moisture contents lower than 6% wet basis were achieved. Pumkin drying was mathematically modeled using the Lewis, Henderson ve Pabis, Page, and logaritmic models, all of which are semi-emperical models widely applied in the literature. Using Fick’s first law effective diffusivities were calculated and compared with those in the literature. Effective diffusion coefficients obtained in the fluidized bed dryer were up to 70% higher than the diffusion coefficients obtained in convective tray dryers. Temperature dependence of effective diffusion coefficients was described by an Arrhenius-type relationship

Molecular dynamics simulations provide molecular insights into the role of HLA-B51 in Behcet's disease pathogenesis

Behcet's disease is an inflammatory disorder of unknown etiology. Genetic tendency has an important role in its pathogenesis, and HLA-B51, a class I MHC antigen, has been recognized as the strongest susceptibility factor for Behcet's disease. Despite the confirmation of the association of HLA-B51 with Behcet's disease in different populations, its pathogenic mechanisms remain elusive. HLA-B51 differs in only two amino acids from HLA-B52, other split antigen of HLA-B5, which is not associated with Behcet's disease. These two amino acids are located in the B pocket of the antigen-binding groove, which occupies the second amino acids of the bound peptides. To understand the nature of the HLA-peptide interactions, differences in structure and dynamics of two HLA alleles were investigated by molecular dynamics simulations using YAYDGKDYI, LPRSTVINI, and IPYQDLPHL peptides. For HLA-B51, all bound peptides fluctuated to larger extent than HLA-B52. Free energy profiles of unbinding process for YAYDGKDYI by steered molecular dynamics simulations showed that unbinding from HLA-B52 results in greater free energy differences than HLA-B51. These results suggest the possibility of an instability of HLA-B51 associated with the repertoire of peptides, and this finding may provide significant insight to its pathogenic role in Behcet's disease

Vehbi Koç ve Ankara Araştırmaları Merkezi

Ankara : İhsan Doğramacı Bilkent Üniversitesi İktisadi, İdari ve Sosyal Bilimler Fakültesi, Tarih Bölümü, 2014.This work is a student project of the The Department of History, Faculty of Economics, Administrative and Social Sciences, İhsan Doğramacı Bilkent University.by Ünsal, Mehmet Süha

Cem Karaca müziği ve sol görüşü

Ankara : İhsan Doğramacı Bilkent Üniversitesi İktisadi, İdari ve Sosyal Bilimler Fakültesi, Tarih Bölümü, 2013.This work is a student project of the The Department of History, Faculty of Economics, Administrative and Social Sciences, İhsan Doğramacı Bilkent University.by Melike Ünal.Ünal, Melike. HIST 200-17ÜNAL HIST 200-17/7 2012-1

Mehmet Nabi İnciler (İnci Baba)'ın hayatı ve Türkiye'de kabadayılık

Ankara : İhsan Doğramacı Bilkent Üniversitesi İktisadi, İdari ve Sosyal Bilimler Fakültesi, Tarih Bölümü, 2015.This work is a student project of the The Department of History, Faculty of Economics, Administrative and Social Sciences, İhsan Doğramacı Bilkent University.by Ünsal, Mehmet Süha

Association of lower serum irisin levels with diabetes mellitus: Irrespective of coronary collateral circulation, and syntax score

OBJECTIVE: Irisin is a myokine thought to be involved in the pathophysiological process of atherosclerosis with its' cardiovascular protective effects. Patients with diabetes mellitus (DM) have lower levels of irisin. Therefore, we investigated whether there is a connection between irisin, DM, coronary collateral circulation (CCC), and SYNTAX scores representing coronary artery disease (CAD) severity. METHODS: This study evaluated 86 patients who have at least one epicardial coronary artery with chronic total occlusion. We included Rentrop 0-1 into the poor CCC group (n=45) and Rentrop 2-3 into the good CCC group (n=41) and measured serum irisin levels. RESULTS: Irisin levels did not differ (17585 [882-37741] pg/ml and (17504 [813-47683] pg/ml, p=0.772) between the two groups. Irisin levels were lower in patients with diabetes (n=41; 14485 [813-29398] pg/ml) than those without diabetes (n=45; 19724 [865-47683] pg/ml (p=0.002). Irisin was not correlated with SYNTAX scores. In multivariate analysis, DM (OR=0.463; CI: 0.184-0.783; p=0.012) was a negative predictor of good CCC development CONCLUSION: Although its level is decreased in patients with diabetes, serum irisin levels have no role in the pathophysiology of collateral development and CAD severity