Statistical Evidence of Mortgage Redlining? A Cautionary Tale

Statistical analyses of mortgage redlining at the neighborhood level have fueled the debate over the existence of racial redlining in mortgage lending, both "proving" and "disproving" that redlining exists, depending upon the type of model used. In this paper, we compare results of different statistical models using data for the Washington, DC metropolitan area to determine their usefulness in providing statistical evidence on this issue. After demonstrating the sensitivity of single-equation models to specification error, we estimate a simultaneous equations model of mortgage credit flows. This model makes it possible to analyze differences in the supply and demand for mortgage credit by the racial composition of the community. We conclude that most, if not all, statistical evidence of racial redlining based on aggregate loan data is at best inconclusive, and more likely, misleading.

Effects of Collisions with Rocky Planets on the Properties of Hot Jupiters

Observed Hot Jupiters exhibit a wide range of physical properties. For a given mass, many planets have inflated radii, while others are surprisingly compact and may harbor large central cores. Motivated by the observational sample, this paper considers possible effects from collisions of smaller rocky planets with gas giant planets. In this scenario, the Jovian planets migrate first and enter into (approximately) 4 day orbits, whereas rocky planets (mass = 0.1-20 that of Earth) migrate later and then encounter the gaseous giants. Previous work indicates that the collision rates are high for such systems. This paper calculates the trajectories of incoming rocky planets as they orbit within the gaseous planets and are subjected to gravitational, frictional, and tidal forces. These collisions always increase the metallicity of the Jovian planets. If the incoming rocky bodies survive tidal destruction and reach the central regions, they provide a means of producing large planetary cores. Both the added metallicity and larger cores act to decrease the radii of the gas giants at fixed mass. The energy released during these collisions provides the Jovian planet with an additional heat source; here we determine the radial layers where kinetic energy of the colliding body is dissipated, including the energy remaining upon impact with the existing core. This process could have long-term effects if the colliding body deposits significant energy deep in the interior, in regions of high opacity. Both Hot Jupiters and newly formed gas giants have inflated radii, large enough to allow incoming rocky planets to survive tidal disruption, enhance the central core mass, and deposit significant energy (in contrast, denser giant planets with the mass and radius of Jupiter are expected to tidally destroy incoming rocky bodies).Comment: 35 pages, 11 figures, accepted to PAS

Founders\u27 Day 1960

Founders\u27 Day 1960 with speakers President Harvey Rice, Professor O.T. Walter, as well as Edmund Wood, Kay Lorans, Fred Koch, and George Bonniwell. Reel #3

Drug resistance outcomes of long-term ART with tenofovir disoproxil fumarate in the absence of virological monitoring

Objectives: The resistance profiles of patients receiving long-term ART in sub-Saharan Africa have been poorly described. This study obtained a sensitive assessment of the resistance patterns associated with long-term tenofovir-based ART in a programmatic setting where virological monitoring is yet to become part of routine care. Methods: We studied subjects who, after a median of 4.2 years of ART, replaced zidovudine or stavudine with tenofovir disoproxil fumarate while continuing lamivudine and an NNRTI. Using deep sequencing, resistance-associated mutations (RAMs) were detected in stored samples collected at tenofovir introduction (T0) and after a median of 4.0 years (T1). Results: At T0, 19/87 (21.8%) subjects showed a detectable viral load and 8/87 (9.2%) had one or more major NNRTI RAMs, whereas 82/87 (94.3%) retained full tenofovir susceptibility. At T1, 79/87 (90.8%) subjects remained on NNRTI-based ART, 5/87 (5.7%) had introduced lopinavir/ritonavir due to immunological failure, and 3/87 (3.4%) had interrupted ART. Whilst 68/87 (78.2%) subjects maintained or achieved virological suppression between T0 and T1, a detectable viral load with NNRTI RAMs at T0 predicted lack of virological suppression at T1. Each treatment interruption, usually reflecting unavailability of the dispensary, doubled the risk of T1 viraemia. Tenofovir, lamivudine and efavirenz selected for K65R, K70E/T, L74I/V and Y115F, alongside M184V and multiple NNRTI RAMs; this resistance profile was accompanied by high viral loads and low CD4 cell counts. Conclusions: Viraemia on tenofovir, lamivudine and efavirenz led to complex resistance patterns with implications for continued drug activity and risk of onward transmission

The Full-sky Astrometric Mapping Explorer -- Astrometry for the New Millennium

FAME is designed to perform an all-sky, astrometric survey with unprecedented accuracy. It will create a rigid astrometric catalog of 4x10^7 stars with 5 < m_V < 15. For bright stars, 5 < m_V < 9, FAME will determine positions and parallaxes accurate to < 50 microarcseconds, with proper motion errors < 50 microarcseconds/year. For fainter stars, 9 < m_V < 15, FAME will determine positions and parallaxes accurate to < 500 microarcseconds, with proper motion errors < 500 microarcseconds/year. It will also collect photometric data on these 4 x 10^7 stars in four Sloan DSS colors.Comment: 6 pages, 4 figures, to appear in "Working on the Fringe

Stars In Other Universes: Stellar structure with different fundamental constants

Motivated by the possible existence of other universes, with possible variations in the laws of physics, this paper explores the parameter space of fundamental constants that allows for the existence of stars. To make this problem tractable, we develop a semi-analytical stellar structure model that allows for physical understanding of these stars with unconventional parameters, as well as a means to survey the relevant parameter space. In this work, the most important quantities that determine stellar properties -- and are allowed to vary -- are the gravitational constant $G$, the fine structure constant $\alpha$, and a composite parameter $C$ that determines nuclear reaction rates. Working within this model, we delineate the portion of parameter space that allows for the existence of stars. Our main finding is that a sizable fraction of the parameter space (roughly one fourth) provides the values necessary for stellar objects to operate through sustained nuclear fusion. As a result, the set of parameters necessary to support stars are not particularly rare. In addition, we briefly consider the possibility that unconventional stars (e.g., black holes, dark matter stars) play the role filled by stars in our universe and constrain the allowed parameter space.Comment: accepted to JCAP, 29 pages, 6 figure

Infection with Mansonella perstans Nematodes in Buruli Ulcer Patients, Ghana.

During August 2010-December 2012, we conducted a study of patients in Ghana who had Buruli ulcer, caused by Mycobacterium ulcerans, and found that 23% were co-infected with Mansonella perstans nematodes; 13% of controls also had M. perstans infection. M. perstans co-infection should be considered in the diagnosis and treatment of Buruli ulcer