An evaluation of polyphenol release from cosmetic formulations

La uvaterapia es una de las propuestas para atenuar las evidencias estéticas provocadas por el envejecimiento extrínseco en la piel, la que se fundamenta en el tratamiento con productos formulados con extracto vegetal y aceite de pepitas de uva, Vitis Vinífera L., ambos con propiedades antioxidantes. El objetivo de este trabajo fue evaluar la liberación de polifenoles presentes en el extracto y en el aceite de pepitas de uva incorporados en formulaciones cosméticas. La liberación de los ingredientes activos desde las formulaciones se evaluó utilizando celdas de difusión de Franz. Los polifenoles totales se cuantifi caron mediante espectrofotometría visible por el método de Folin Denis. La liberación de polifenoles desde los vehículos formulados, gel y emulsión, se ajustó al modelo cinético de la raíz cuadrada del tiempo, siendo mayor la velocidad de liberación desde el gel.One of the proposed treatments for extrinsic skin aging processes is Grape therapy, whose active ingredients, known to possess antioxidant properties, are the vegetable and seed oil extracts from the Vitis Vinífera L. grape species. The objective of the present work was to evaluate the release of polyphenol compounds from these extracts, retained in gel and emulsion based cosmetic formulations, using Franz diffusion cells. A quantifi cation of total active ingredient release was also carried out using the Folin Denis visible spectrophotometry method. Polyphenol release from both types of formulation was found to follow a square root of time kinetic model, but a higher rate of release was obtained from the gel formulation

Low-cost electrochemical impedance spectroscopy system for corrosion monitoring of metallic antiquities and works of art

Electrochemical impedance spectroscopy (EIS) is recognized to be a powerful and noninvasive technique to test the integrity of protective coatings on memorials, but commercial EIS systems are rather costly though versatile devices. This paper describes a low cost and portable EIS system that is based on a compact digital signal processor (DSP) board and embeds the potentiostatic function so that it can be used without requiring an external potentiostat. The software that runs on the DSP is designed to analyze the electrochemical impedance only in a reduced frequency range in order to produce a simple corrosion alert result. The device is equipped with a digital interface and can be connected to a personal computer to carry out a complete frequency analysis and perform a more complex data processing

Exposure-Tolerant Imaging Solution forCultural Heritage Monitoring

This paper describes a simple and cheap solution specifically designed for monitoring the degradation of thin coatings employed for metal protection. The proposed solution employs a commercial photocamera and a frequency-domain-based approach that is capable of highlighting the surface uniformity changes due to initial corrosion. Even though the proposed solution is specifically designed to monitor the long-time performance of protective coatings employed for the restoration of silver artifacts, it can be successfully used also for assessing the conservation state of other ancient metallic works of art. The proposed solution is made tolerant to exposure changes by using a procedure for sensor nonlinearity identification and correction, does not require a precise lighting control, and employs only free open-source software, so that its overall cost is very low and can be used also by not specifically trained operator

Prescribed hypocaloric nutrition support for critically-ill adults

Background There are controversies about the amount of calories and the type of nutritional support that should be given to critically‐ill people. Several authors advocate the potential benefits of hypocaloric nutrition support, but the evidence is inconclusive. Objectives To assess the effects of prescribed hypocaloric nutrition support in comparison with standard nutrition support for critically‐ill adults Search methods We searched the Cochrane Central Register of Controlled Trials (CENTRAL, Cochrane Library), MEDLINE, Embase and LILACS (from inception to 20 June 2017) with a specific strategy for each database. We also assessed three websites, conference proceedings and reference lists, and contacted leaders in the field and the pharmaceutical industry for undetected/unpublished studies. There was no restriction by date, language or publication status. Selection criteria We included randomized and quasi‐randomized controlled trials comparing hypocaloric nutrition support to normo‐ or hypercaloric nutrition support or no nutrition support (e.g. fasting) in adults hospitalized in intensive care units (ICUs). Data collection and analysis We used standard methodological procedures expected by Cochrane. We meta‐analysed data for comparisons in which clinical heterogeneity was low. We conducted prespecified subgroup and sensitivity analyses, and post hoc analyses, including meta‐regression. Our primary outcomes were: mortality (death occurred during the ICU and hospital stay, or 28‐ to 30‐day all‐cause mortality); length of stay (days stayed in the ICU and in the hospital); and Infectious complications. Secondary outcomes included: length of mechanical ventilation. We assessed the quality of evidence with GRADE. Main results We identified 15 trials, with a total of 3129 ICU participants from university‐associated hospitals in the USA, Colombia, Saudi Arabia, Canada, Greece, Germany and Iran. There are two ongoing studies. Participants suffered from medical and surgical conditions, with a variety of inclusion criteria. Four studies used parenteral nutrition and nine studies used only enteral nutrition; it was unclear whether the remaining two used parenteral nutrition. Most of them could not achieve the proposed caloric targets, resulting in small differences in the administered calories between intervention and control groups. Most studies were funded by the US government or non‐governmental associations, but three studies received funding from industry. Five studies did not specify their funding sources. The included studies suffered from important clinical and statistical heterogeneity. This heterogeneity did not allow us to report pooled estimates of the primary and secondary outcomes, so we have described them narratively. When comparing hypocaloric nutrition support with a control nutrition support, for hospital mortality (9 studies, 1775 participants), the risk ratios ranged from 0.23 to 5.54; for ICU mortality (4 studies, 1291 participants) the risk ratios ranged from 0.81 to 5.54, and for mortality at 30 days (7 studies, 2611 participants) the risk ratios ranged from 0.79 to 3.00. Most of these estimates included the null value. The quality of the evidence was very low due to unclear or high risk of bias, inconsistency and imprecision. Participants who received hypocaloric nutrition support compared to control nutrition support had a range of mean hospital lengths of stay of 15.70 days lower to 10.70 days higher (10 studies, 1677 participants), a range of mean ICU lengths of stay 11.00 days lower to 5.40 days higher (11 studies, 2942 participants) and a range of mean lengths of mechanical ventilation of 13.20 days lower to 8.36 days higher (12 studies, 3000 participants). The quality of the evidence for this outcome was very low due to unclear or high risk of bias in most studies, inconsistency and imprecision. The risk ratios for infectious complications (10 studies, 2804 participants) of each individual study ranged from 0.54 to 2.54. The quality of the evidence for this outcome was very low due to unclear or high risk of bias, inconsistency and imprecision We were not able to explain the causes of the observed heterogeneity using subgroup and sensitivity analyses or meta‐regression. Authors' conclusions The included studies had substantial clinical heterogeneity. We found very low‐quality evidence about the effects of prescribed hypocaloric nutrition support on mortality in hospital, in the ICU and at 30 days, as well as in length of hospital and ICU stay, infectious complications and the length of mechanical ventilation. For these outcomes there is uncertainty about the effects of prescribed hypocaloric nutrition, since the range of estimates includes both appreciable benefits and harms. Given these limitations, results must be interpreted with caution in the clinical field, considering the unclear balance of the risks and harms of this intervention. Future research addressing the clinical heterogeneity of participants and interventions, study limitations and sample size could clarify the effects of this intervention.Fil: Perman, Mario I. Hospital Italiano; ArgentinaFil: Ciapponi, Agustín. Instituto de Efectividad Clínica y Sanitaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Franco, Juan V.A.. Hospital Italiano; ArgentinaFil: Loudet, Cecilia. Universidad Nacional de La Plata; ArgentinaFil: Crivelli, Adriana. Hospital HIGA San Martín; ArgentinaFil: Garrote, Virginia. Hospital Italiano; ArgentinaFil: Perman, Gastón. Hospital Italiano; Argentin

The Influence of Pay as a Motivator on the Research Productivity of Educators

Research is one of a university’s primary functions. This study aimed to determine the influence of pay as a motivator on the research productivity of educators. It utilized a mixed-methods research design. The respondents are 150 faculty members randomly selected during the 1st semester of the SY 2022-2023. It used a validated survey instrument. The results show a 0.279 weakly positive correlation between the two variables. The computed t-value for this predictor exceeds the 95% confidence interval of (.492, 1.735) by a significant margin of p=0.001, hence the researchers reject the null hypothesis, which states that pay as a motivator significantly does not influence research productivity. For the qualitative phase, the emerging themes include the issues and problems regarding research productivity including lack of time due to work overload, lack of knowledge in research writing, tedious procedures in the research approval, and lack of work motivation/encouragement. Thus, the researchers crafted recommendations that could help enhance faculty members ’ research productivity

Perdas de nitrogênio por Brachiaria decumbens após a aplicação de glifosato ou glufosinato de amônio

Nitrogen losses from the soil-plant system may be influenced by herbicide applications. In order to evaluate N loss in brachiaria (Brachiaria decumbens) after application of the herbicides glyphosate and glufosinate-ammonium, an experiment was carried out in a greenhouse as a completely randomized design, with three treatments and six replicates. Treatments were as follows: i) desiccation of brachiaria-plants with glyphosate; ii) desiccation of brachiaria-plants with glufosinate-ammonium; and iii) control, without herbicide application. The plants were cultivated in 4 kg pots of sandy soil and fertilized with ammonium sulfate- 15N, (200 mg kg-1) in order to quantify the allocation of the fertilizer-N and its recovery in the soil-plant system. Plants treated with the herbicides had less N accumulation and less recovery of the fertilizer-N (15N) relative to the control. In the soil, the greatest recovery of 15N-fertilizer occurred for treatments where N was applied, possibly due to the occurrence of other N compound losses to the soil, like root exudation and root death. The total recovery of 15N-fertilizer in the soil-plant system was higher in the control than in the treated plants showing the direct action of the herbicides on nitrogen loss, and especially by the above-ground part of the brachiaria plants.As perdas de nitrogênio no sistema solo-planta podem ser influenciadas pela aplicação de herbicidas. Com o objetivo de avaliar a perda de N do capim-Brachiaria (Brachiaria decumbens) após a aplicação dos herbicidas glifosato e glufosinato de amônio, foi realizado um experimento em casa-de-vegetação em delineamento inteiramente aleatorizado (DIA), com três tratamentos e seis repetições. Os tratamentos foram os seguintes: i) dessecação de plantas de braquiária com o herbicida glifosato; ii) dessecação de plantas de braquiária com herbicida glufosinato de amônio e iii) testemunha, sem aplicação de herbicida. As plantas foram cultivadas em vasos com 4 kg de solo arenoso e foram fertilizadas com sulfato de amônio (15N), na dose de 200 mg kg-1, com o intuito de quantificar a alocação de N-fertilizante (15N) e sua recuperação no sistema solo-planta. As plantas tratadas com os herbicidas apresentaram menor acúmulo de N e menor recuperação do N-fertilizante (15N) em relação à testemunha. No solo a maior recuperação do 15N-fertilizante ocorreu nos tratamentos em que foram aplicados os herbicidas, possivelmente, devido à ocorrência de perda de compostos nitrogenados para o solo por exsudação radicular e morte de raízes. A recuperação total do 15N-fertilizante no sistema solo-planta foi maior na testemunha que nos tratamentos, evidenciando-se a ação direta dos herbicidas nas perdas de nitrogênio, especialmente, pela parte aérea do capim-Brachiaria

El maltrato infantil en el proceso educativo de los niños y niñas de 9 a 12 años en el marco de los derechos del niño: caso de estudio de la Escuela Fiscal Mixta Brethren

El maltrato es visto como una forma de relación, como una costumbre que se ha llegado a naturalizar y la misma que se ha convertido en algo que pasa de una manera absolutamente normal. Y sólo algunos casos que se ensañan por su crueldad aparecen y causan escándalos, incluso llegan a pasar por televisión pero todo es pasajero. Es así que el maltrato diario, cotidiano y a veces hasta corriente, ni si quiera es tomado en cuenta por la sociedad y menos por las autoridades

Project C.O.R.E.: Coaching Opportunities with Real Experiences

Retention and graduation rates of VCU men of color (MOC) is significantly lower than white men and women of color. Due to demonstrated significant attrition occurring after the sophomore year, Project C.O.R.E. (Coaching Opportunities with Real Experiences) is proposed as a sophomore-focused program that builds upon an existing freshman course on professional development for MOC. While the first-year course introduces students to a VCU support network, Project C.O.R.E. aims to increase university retention by expanding the student support network to members of the local community. Students are paired with community coaches, predominantly VCU alumni, to enhance their career and life-skills development. This program provides continued community, guidance, and support to encourage MOC to continue on the path to graduation