Labor Earnings Respond Differently to Income-Tax and to Payroll-Tax Reforms

We estimate the responses of gross labor earnings with respect to marginal and average net-of-tax rates in France over the period 2003-2006. We exploit a series of reforms to the income-tax and the payroll-tax schedules that affect individuals who earn less than twice the minimum wage. Our estimate for the elasticity of gross labor earnings with respect to the marginal net-of-income-tax rate is around 0.2, while we find no response to the marginal net-of-payroll-tax rate. The elasticity with respect to the average net-of-tax rates is not significant for the income-tax schedule, while it is close to -1 for the payroll-tax schedule. A plausible explanation is the existence of significant labor supply responses to the income-tax schedule, combined with a short-term rigidity of the hourly taxable wage (i.e. the gross wage minus payroll taxes), casting doubts about public finance analysis that assumes perfect competition on the labor market. Finally, the effect of the net-of-income-tax rate seems to be driven by labor supply participation decisions, in particular those of females.labor earnings, payroll tax, income tax

Streaming potential dependence on water-content in Fontainebleau sand

The final version is available on www.blackwell-synergy.comInternational audienceThe electrokinetic potential results from the coupling between the water flow and the electrical current because of the presence of ions within water. The electrokinetic coupling is well described in fluid-saturated media, however its behaviour under unsaturated flow conditions is still discussed. We propose here an experimental approach to investigate streaming potential variations in sand at unsaturated conditions. We present for the first time continuous records of the electrokinetic coefficient as a function of water content. Two drainage experiments have been performed within a column filled with a clean sand. Streaming potential measurements are combined with water pressure and water content measurements every 10 centimeters along the column. In order to model hydrodymanics during the experiments, we solve Richards equation coupled with an inverse problem to estimate the hydraulic parameters of the constitutive relations between hydraulic conductivity, water pressure and water content. The electrokinetic coefficient $C$ shows a more complex behaviour for unsaturated conditions than it was previously reported and cannot be fitted by the existing models. The electrokinetic coefficient increases first when water saturation decreases from 100\% to about 65\% - 80\%, and then decreases as the water saturation decreases, whereas all previous works described a monotone decrease of the normalized electrokinetic coupling as water saturation decreases. We delimited two water saturation domains, and deduced two different empirical laws describing the evolution of the electrokinetic coupling for unsaturated conditions. Moreover we introduce the concept of the electrokinetic residual saturation $S_w^{r,ek}$, which allows us to propose a new model derived from the approach of the relative permeability used in hydrodynamics

Fitness, inclusive fitness, and optimization

Individual-as-maximizing agent analogies result in a simple understanding of the functioning of the biological world. Identifying the conditions under which individuals can be regarded as fitness maximizing agents is thus of considerable interest to biologists. Here, we compare different concepts of fitness maximization, and discuss within a single framework the relationship between Hamilton's (J Theor Biol 7:1-16, 1964) model of social interactions, Grafen's (J Evol Biol 20:1243-1254,2007a) formal Darwinism project, and the idea of evolutionary stable strategies. We distinguish cases where phenotypic effects are additive separable or not, the latter not being covered by Grafen's analysis. In both cases it is possible to define a maximand, in the form of an objective function ϕ(z), whose argument is the phenotype of an individual and whose derivative is proportional to Hamilton's inclusive fitness effect. However, this maximand can be identified with the expression for fecundity or fitness only in the case of additive separable phenotypic effects, making individual-as-maximizing agent analogies unattractive (although formally correct) under general situations of social interactions. We also feel that there is an inconsistency in Grafen's characterization of the solution of his maximization program by use of inclusive fitness arguments. His results are in conflict with those on evolutionary stable strategies obtained by applying inclusive fitness theory, and can be repaired only by changing the definition of the problem

Multichannel spectral mode of the ALOHA up-conversion interferometer

International audienceIn this paper, we propose a multichannel spectral configuration of the Astronomical Light Optical Hybrid Analysis (ALOHA) instrument dedicated to high resolution imaging. A frequency conversion process is implemented in each arm of an interferometer to transfer the astronomical light to a shorter wavelength domain. Exploiting the spectral selectivity of this non-linear optical process, we propose to use a set of independent pump lasers in order to simultaneously study multiple spectral channels. This principle is experimentally demonstrated with a dual-channel configuration as a proof-of-principle

Optimisation de la méthode des éléments finis mixtes hybrides pour la modélisation des écoulements variablement saturés

Parmi les méthodes de résolution numérique utilisées en mécanique, la méthode des éléments finis mixtes hybrides constitue une approche récente et performante. Certaines techniques, notamment la condensation de la masse et le raffinement fictif, permettent d’améliorer la précision et la rapidité de cette méthode. L’illustration est réalisée pour des problèmes d’écoulements en milieux poreux variablement saturés qui sont décrits selon une approche mécaniste par l’équation de Richards

Cerebrospinal fluid phospho-tau T217 outperforms T181 as a biomarker for the differential diagnosis of Alzheimer\u27s disease and PET amyloid-positive patient identification

BACKGROUND: Cerebrospinal fluid biomarker profiles characterized by decreased amyloid-beta peptide levels and increased total and phosphorylated tau levels at threonine 181 (pT181) are currently used to discriminate between Alzheimer\u27s disease and other neurodegenerative diseases. However, these changes are not entirely specific to Alzheimer\u27s disease, and it is noteworthy that other phosphorylated isoforms of tau, possibly more specific for the disease process, have been described in the brain parenchyma of patients. The precise detection of these isoforms in biological fluids remains however a challenge. METHODS: In the present study, we used the latest quantitative mass spectrometry approach, which achieves a sensitive detection in cerebrospinal fluid biomarker of two phosphorylated tau isoforms, pT181 and pT217, and first analyzed a cohort of probable Alzheimer\u27s disease patients and patients with other neurological disorders, including tauopathies, and a set of cognitively normal controls. We then checked the validity of our results on a second cohort comprising cognitively normal individuals and patients with mild cognitive impairments and AD stratified in terms of their amyloid status based on PiB-PET imaging methods. RESULTS: In the first cohort, pT217 but not pT181 differentiated between Alzheimer\u27s disease patients and those with other neurodegenerative diseases and control subjects much more specificity and sensitivity than pT181. T217 phosphorylation was increased by 6.0-fold in patients with Alzheimer\u27s disease whereas T181 phosphorylation was only increased by 1.3-fold, when compared with control subjects. These results were confirmed in the case of a second cohort, in which the pT217 cerebrospinal fluid levels marked out amyloid-positive patients with a sensitivity and a specificity of more than 90% (AUC 0.961; CI 0.874 to 0.995). The pT217 concentrations were also highly correlated with the PiB-PET values (correlation coefficient 0.72; P \u3c 0.001). CONCLUSIONS: Increased cerebrospinal fluid pT217 levels, more than those of pT181, are highly specific biomarkers for detecting both the preclinical and advanced forms of Alzheimer\u27s disease. This finding should greatly improve the diagnosis of Alzheimer\u27s disease, along with the correlations found to exist between pT217 levels and PiB-PET data. It also suggests that pT217 is a promising potential target for therapeutic applications and that a link exists between amyloid and tau pathology

Archaeal Diversity and CO 2

Groundwater environments provide habitats for diverse microbial communities, and although Archaea usually represent a minor fraction of communities, they are involved in key biogeochemical cycles. We analysed the archaeal diversity within a mixed carbonate-rock/siliciclastic-rock aquifer system, vertically from surface soils to subsurface groundwater including aquifer and aquitard rocks. Archaeal diversity was also characterized along a monitoring well transect that spanned surface land uses from forest/woodland to grassland and cropland. Sequencing of 16S rRNA genes showed that only a few surface soil-inhabiting Archaea were present in the groundwater suggesting a restricted input from the surface. Dominant groups in the groundwater belonged to the marine group I (MG-I) Thaumarchaeota and the Woesearchaeota. Most of the groups detected in the aquitard and aquifer rock samples belonged to either cultured or predicted lithoautotrophs (e.g., Thaumarchaeota or Hadesarchaea). Furthermore, to target autotrophs, a series of 13CO2 stable isotope-probing experiments were conducted using filter pieces obtained after filtration of 10,000 L of groundwater to concentrate cells. These incubations identified the SAGMCG Thaumarchaeota and Bathyarchaeota as groundwater autotrophs. Overall, the results suggest that the majority of Archaea on rocks are fixing CO2, while archaeal autotrophy seems to be limited in the groundwater