171 research outputs found
Design and Analysis Tools for Supersonic Inlets
Computational tools are being developed for the design and analysis of supersonic inlets. The objective is to update existing tools and provide design and low-order aerodynamic analysis capability for advanced inlet concepts. The Inlet Tools effort includes aspects of creating an electronic database of inlet design information, a document describing inlet design and analysis methods, a geometry model for describing the shape of inlets, and computer tools that implement the geometry model and methods. The geometry model has a set of basic inlet shapes that include pitot, two-dimensional, axisymmetric, and stream-traced inlet shapes. The inlet model divides the inlet flow field into parts that facilitate the design and analysis methods. The inlet geometry model constructs the inlet surfaces through the generation and transformation of planar entities based on key inlet design factors. Future efforts will focus on developing the inlet geometry model, the inlet design and analysis methods, a Fortran 95 code to implement the model and methods. Other computational platforms, such as Java, will also be explored
Observations of the geology and geomorphology of the 1999 Marsokhod test site
The Marsokhod rover returned data from six stations that were used to decipher the geomorphology and geology of a region not previously visited by members of the geomorphology field team. Satellite images and simulated descent images provided information about the regional setting. The landing zone was on an alluvial apron flanking a mountain block to the west and playa surface to the east. Rover color images, infrared spectra analysis of the mountains, and the apron surface provided insight into the rock composition of the nearby mountains. From the return data the geomorphology team interpreted the region to consist of compressionally deformed, ancient marine sediments and igneous rocks exposed by more recent extensional tectonics. Unconsolidated alluvial materials blanket the lower flanks of the mountains. An ancient shoreline cut into alluvial material marks a high stand of water during a past, wetter climate period. Playa sediments floor a present-day, seasonally, dry lake. Observations made by the rover using panoramic and close-up (hand specimens—scale) image data and color scene data confirmed the presence of boulders, cobbles, and fines of various provinces. Rover traverses to sites identified as geologically distinct, such as a fan, channel, shoreline, and playa, provided useful clues to the geologic interpretations. Analysis of local rocks was given context only through comparison with distant geologic features. These results demonstrated the importance of a multifaceted approach to site interpretation through comparison of interpretations derived by differing geologic techniques
Scaling critical behavior of superconductors at zero magnetic field
We consider the scaling behavior in the critical domain of superconductors at
zero external magnetic field. The first part of the paper is concerned with the
Ginzburg-Landau model in the zero magnetic field Meissner phase. We discuss the
scaling behavior of the superfluid density and we give an alternative proof of
Josephson's relation for a charged superfluid. This proof is obtained as a
consequence of an exact renormalization group equation for the photon mass. We
obtain Josephson's relation directly in the form , that
is, we do not need to assume that the hyperscaling relation holds. Next, we
give an interpretation of a recent experiment performed in thin films of
. We argue that the measured mean field like
behavior of the penetration depth exponent is possibly associated with a
non-trivial critical behavior and we predict the exponents and
for the correlation lenght and specific heat, respectively. In the
second part of the paper we discuss the scaling behavior in the continuum dual
Ginzburg-Landau model. After reviewing lattice duality in the Ginzburg-Landau
model, we discuss the continuum dual version by considering a family of
scalings characterized by a parameter introduced such that
, where is the bare mass of the magnetic
induction field. We discuss the difficulties in identifying the renormalized
magnetic induction mass with the photon mass. We show that the only way to have
a critical regime with is having , that
is, with having the scaling behavior of the renormalized photon mass.Comment: RevTex, 15 pages, no figures; the subsection III-C has been removed
due to a mistak
Spin Degeneracy and Conductance Fluctuations in Open Quantum Dots
The dependence of mesoscopic conductance fluctuations on parallel magnetic
field is used as a probe of spin degeneracy in open GaAs quantum dots. The
variance of fluctuations at high parallel field is reduced from the low-field
variance (with broken time-reversal symmetry) by factors ranging from roughly
two in a 1 square-micron dot at low temperature, to four or greater in 8
square-micron dots. The factor of two is expected for simple Zeeman splitting
of spin degenerate channels. A possible explanation for the unexpected larger
factors in terms of field-dependent spin orbit scattering is proposed.Comment: Includes new reference to related theoretical work, cond-mat/0010064.
Other minor changes. Related papers at http://marcuslab.harvard.ed
Extreme sensitivity of the spin-splitting and 0.7 anomaly to confining potential in one-dimensional nanoelectronic devices
Quantum point contacts (QPCs) have shown promise as nanoscale spin-selective
components for spintronic applications and are of fundamental interest in the
study of electron many-body effects such as the 0.7 x 2e^2/h anomaly. We report
on the dependence of the 1D Lande g-factor g* and 0.7 anomaly on electron
density and confinement in QPCs with two different top-gate architectures. We
obtain g* values up to 2.8 for the lowest 1D subband, significantly exceeding
previous in-plane g-factor values in AlGaAs/GaAs QPCs, and approaching that in
InGaAs/InP QPCs. We show that g* is highly sensitive to confinement potential,
particularly for the lowest 1D subband. This suggests careful management of the
QPC's confinement potential may enable the high g* desirable for spintronic
applications without resorting to narrow-gap materials such as InAs or InSb.
The 0.7 anomaly and zero-bias peak are also highly sensitive to confining
potential, explaining the conflicting density dependencies of the 0.7 anomaly
in the literature.Comment: 23 pages, 7 figure
Benthic pH gradients across a range of shelf sea sediment types linked to sediment characteristics and seasonal variability
This study used microelectrodes to record pH profiles in fresh shelf sea sediment cores collected across a range of different sediment types within the Celtic Sea. Spatial and temporal variability was captured during repeated measurements in 2014 and 2015. Concurrently recorded oxygen microelectrode profiles and other sedimentary parameters provide a detailed context for interpretation of the pH data. Clear differences in profiles were observed between sediment type, location and season. Notably, very steep pH gradients exist within the surface sediments (10–20 mm), where decreases greater than 0.5 pH units were observed. Steep gradients were particularly apparent in fine cohesive sediments, less so in permeable sandier matrices. We hypothesise that the gradients are likely caused by aerobic organic matter respiration close to the sediment–water interface or oxidation of reduced species at the base of the oxic zone (NH4+, Mn2+, Fe2+, S−). Statistical analysis suggests the variability in the depth of the pH minima is controlled spatially by the oxygen penetration depth, and seasonally by the input and remineralisation of deposited organic phytodetritus. Below the pH minima the observed pH remained consistently low to maximum electrode penetration (ca. 60 mm), indicating an absence of sub-oxic processes generating H+ or balanced removal processes within this layer. Thus, a climatology of sediment surface porewater pH is provided against which to examine biogeochemical processes. This enhances our understanding of benthic pH processes, particularly in the context of human impacts, seabed integrity, and future climate changes, providing vital information for modelling benthic response under future climate scenarios
Evaluation of variants in the selectin genes in age-related macular degeneration
<p>Abstract</p> <p>Background</p> <p>Age-related macular degeneration (AMD) is a common disease of the elderly that leads to loss of the central visual field due to atrophic or neovascular events. Evidence from human eyes and animal models suggests an important role for macrophages and endothelial cell activation in the pathogenesis of AMD. We sought to determine whether common ancestral variants in genes encoding the selectin family of proteins are associated with AMD.</p> <p>Methods</p> <p>Expression of E-selectin, L-selectin and P-selectin was examined in choroid and retina by quantitative PCR and immunofluorescence. Samples from patients with AMD (n = 341) and controls (n = 400) were genotyped at a total of 34 SNPs in the <it>SELE</it>, <it>SELL </it>and <it>SELP </it>genes. Allele and genotype frequencies at these SNPs were compared between AMD patients and controls as well as between subtypes of AMD (dry, geographic atrophy, and wet) and controls.</p> <p>Results</p> <p>High expression of all three selectin genes was observed in the choroid as compared to the retina. Some selectin labeling of retinal microglia, drusen cores and the choroidal vasculature was observed. In the genetic screen of AMD versus controls, no positive associations were observed for <it>SELE </it>or <it>SELL</it>. One SNP in <it>SELP </it>(rs3917751) produced p-values < 0.05 (uncorrected for multiple measures). In the subtype analyses, 6 SNPs (one in <it>SELE</it>, two in <it>SELL</it>, and three in <it>SELP</it>) produced p-values < 0.05. However, when adjusted for multiple measures with a Bonferroni correction, only one SNP in <it>SELP </it>(rs3917751) produced a statistically significant p-value (p = 0.0029).</p> <p>Conclusions</p> <p>This genetic screen did not detect any SNPs that were highly associated with AMD affection status overall. However, subtype analysis showed that a single SNP located within an intron of <it>SELP </it>(rs3917751) is statistically associated with dry AMD in our cohort. Future studies with additional cohorts and functional assays will clarify the biological significance of this discovery. Based on our findings, it is unlikely that common ancestral variants in the other selectin genes (<it>SELE </it>and <it>SELL</it>) are risk factors for AMD. Finally, it remains possible that sporadic or rare mutations in <it>SELE</it>, <it>SELL</it>, or <it>SELP </it>have a role in the pathogenesis of AMD.</p
A Functional Genomic Screen Combined with Time-Lapse Microscopy Uncovers a Novel Set of Genes Involved in Dorsal Closure of Drosophila Embryos
Morphogenesis, the establishment of the animal body, requires the coordinated rearrangement of cells and tissues regulated by a very strictly-determined genetic program. Dorsal closure of the epithelium in the Drosophila melanogaster embryo is one of the best models for such a complex morphogenetic event. To explore the genetic regulation of dorsal closure, we carried out a large-scale RNA interference-based screen in combination with in vivo time-lapse microscopy and identified several genes essential for the closure or affecting its dynamics. One of the novel dorsal closure genes, the small GTPase activator pebble (pbl), was selected for detailed analysis. We show that pbl regulates actin accumulation and protrusion dynamics in the leading edge of the migrating epithelial cells. In addition, pbl affects dorsal closure dynamics by regulating head involution, a morphogenetic process mechanically coupled with dorsal closure. Finally, we provide evidence that pbl is involved in closure of the adult thorax, suggesting its general requirement in epithelial closure processes
Transglutaminase 6: a protein associated with central nervous system development and motor function.
Transglutaminases (TG) form a family of enzymes that catalyse various post-translational modifications of glutamine residues in proteins and peptides including intra- and intermolecular isopeptide bond formation, esterification and deamidation. We have characterized a novel member of the mammalian TG family, TG6, which is expressed in a human carcinoma cell line with neuronal characteristics and in mouse brain. Besides full-length protein, alternative splicing results in a short variant lacking the second β-barrel domain in man and a variant with truncated β-sandwich domain in mouse. Biochemical data show that TG6 is allosterically regulated by Ca(2+) and guanine nucleotides. Molecular modelling indicates that TG6 could have Ca(2+) and GDP-binding sites related to those of TG3 and TG2, respectively. Localization of mRNA and protein in the mouse identified abundant expression of TG6 in the central nervous system. Analysis of its temporal and spatial pattern of induction in mouse development indicates an association with neurogenesis. Neuronal expression of TG6 was confirmed by double-labelling of mouse forebrain cells with cell type-specific markers. Induction of differentiation in mouse Neuro 2a cells with NGF or dibutyryl cAMP is associated with an upregulation of TG6 expression. Familial ataxia has recently been linked to mutations in the TGM6 gene. Autoantibodies to TG6 were identified in immune-mediated ataxia in patients with gluten sensitivity. These findings suggest a critical role for TG6 in cortical and cerebellar neurons
Organotin compounds in surface sediments of the Southern Baltic coastal zone: a study on the main factors for their accumulation and degradation
Abstract Sediment samples were collected in the Gulf of
Gdańsk, and the Vistula and Szczecin Lagoons—all located
in the coastal zone of the Southern Baltic Sea—just after the
total ban on using harmful organotins in antifouling paints on
ships came into force, to assess their butyltin and phenyltin
contamination extent. Altogether, 26 sampling stations were
chosen to account for different potential exposure to organotin
pollution and environmental conditions: from shallow and
well-oxygenated waters, shipping routes and river mouths,
to deep and anoxic sites. Additionally, the organic carbon
content, pigment content, and grain size of all the sediment
samples were determined, and some parameters of the nearbottom
water (oxygen content, salinity, temperature) were
measured as well. Total concentrations of butyltin compounds
ranged between 2 and 182 ng Sn g−1 d.w., whereas phenyltins
were below the detection limit. Sediments from the Gulf of
Gdańsk and Vistula Lagoon were found moderately contaminated
with tributyltin, whereas those from the Szczecin
Lagoon were ranked as highly contaminated. Butyltin degradation
indices prove a recent tributyltin input into the sediments
adjacent to sites used for dumping for dredged harbor
materials and for anchorage in the Gulf of Gdańsk (where two
big international ports are located), and into those collected in
the Szczecin Lagoon. Essential factors affecting the degradation
and distribution of organotins, based on significant correlations
between butyltins and environmental variables, were
found in the study area
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