2,886 research outputs found
Resolving Voluntary Mental Health Treatment Disputes in the Community Setting: Benefits of and Barriers to Effective Mediation
Published in cooperation with the American Bar Association Section of Dispute Resolutio
Kinetics of the reaction of nitric oxide with hydrogen
Mixtures of NO and H2 diluted in argon or krypton were heated by incident shock waves, and the infrared emission from the fundamental vibration-rotation band of NO at 5.3 microns was used to monitor the time-varying NO concentration. The reaction kinetics were studied in the temperature range 2400-4500 K using a shock-tube technique. The decomposition of nitric oxide behind the shock was found to be modeled well by a fifteen-reaction system. A principle result of the study was the determination of the rate constant for the reaction H + NO yields N + OH, which may be the rate-limiting step for NO removal in some combustion systems. Experimental values of k sub 1 were obtained for each test through comparisons of measured and numerically predicted NO profiles
Innate Immunity in Lobsters: Partial Purification and Characterization of a Panulirus cygnus Anti-A Lectin
A lectin detected in haemolymph from the Australian spiny lobster Panulirus cygnus agglutinated human ABO Group A cells to a higher titre than Group O or B. The lectin also agglutinated rat and sheep erythrocytes, with reactivity with rat erythrocytes strongly enhanced by treatment with the proteolytic enzyme papain, an observation consistent with reactivity via a glycolipid. The lectin, purified by affinity chromatography on fixed rat-erythrocyte stroma, was inhibited equally by N-acetylglucosamine and N-acetylgalactosamine. Comparison of data from gel filtration of haemolymph (behaving as a 1,800,000 Da macromolecule), and polyacrylamide gel electrophoresis of purified lectin (a single 67,000 Da band), suggested that in haemolymph the lecin was a multimer. The purified anti-A lectin autoprecipitated unless the storage solution contained chaotropic inhibitors (125 mmol/L sucrose: 500 mmol/L urea). The properties of this anti-A lectin and other similar lectins are consistent with a role in innate immunity in these invertebrates
Physical disruption of intervertebral disc promotes cell clustering and a degenerative phenotype
© 2019, The Author(s). To test the hypothesis that physical disruption of an intervertebral disc disturbs cell-matrix binding, leading to cell clustering and increased expression of matrix degrading enzymes that contribute towards degenerative disc cell phenotype. Lumbar disc tissue was removed at surgery from 21 patients with disc herniation, 11 with disc degeneration, and 8 with adolescent scoliosis. 5 μm sections were examined with histology, and 30-µm sections by confocal microscopy. Antibodies were used against integrin α5beta1, matrix metalloproteinases (MMP) 1, MMP-3, caspase 3, and denatured collagen types I and II. Spatial associations were sought between cell clustering and various degenerative features. An additional, 11 non-herniated human discs were used to examine causality: half of each specimen was cultured in a manner that allowed free ‘unconstrained’ swelling (similar to a herniated disc in vivo), while the other half was cultured within a perspex ring that allowed ‘constrained’ swelling. Changes were monitored over 36 h using live-cell imaging. 1,9-Di-methyl methylene blue (DMMB) assay for glycosaminoglycan loss was carried out from tissue medium. Partially constrained specimens showed little swelling or cell movement in vitro. In contrast, unconstrained swelling significantly increased matrix distortion, glycosaminoglycan loss, exposure of integrin binding sites, expression of MMPs 1 and 3, and collagen denaturation. In the association studies, herniated disc specimens showed changes that resembled unconstrained swelling in vitro. In addition, they exhibited increased cell clustering, apoptosis, MMP expression, and collagen denaturation compared to ‘control’ discs. Results support our hypothesis. Further confirmation will require longitudinal animal experiments
H2 reformation in post-shock regions
H2 formation is an important process in post-shock regions, since H2 is an
active participant in the cooling and shielding of the environment. The onset
of H2 formation therefore has a strong effect on the temperature and chemical
evolution in the post shock regions. We recently developed a model for H2
formation on a graphite surface in warm conditions. The graphite surface acts
as a model system for grains containing large areas of polycyclic aromatic
hydrocarbon structures. Here this model is used to obtain a new description of
the H2 formation rate as a function of gas temperature that can be implemented
in molecular shock models. The H2 formation rate is substantially higher at
high gas temperatures as compared to the original implementation of this rate
in shock models, because of the introduction of H atoms which are chemically
bonded to the grain (chemisorption). Since H2 plays such a key role in the
cooling, the increased rate is found to have a substantial effect on the
predicted line fluxes of an important coolant in dissociative shocks [O I] at
63.2 and 145.5 micron. With the new model a better agreement between model and
observations is obtained. Since one of the goals of Herschel/PACS will be to
observe these lines with higher spatial resolution and sensitivity than the
former observations by ISO-LWS, this more accurate model is very timely to help
with the interpretation of these future results.Comment: 12 pages, 3 figures, 1 table, accepted in MNRAS Letter
Decomposition of NO studied by infrared emission and CO laser absorption
A diagnostic technique for monitoring the concentration of NO using absorption of CO laser radiation was developed and applied in a study of the decomposition kinetics of NO. Simultaneous measurements of infrared emission by NO at 5.3 microns were also made to validate the laser absorption technique. The data were obtained behind incident shocks in NO-N2O-Ar (or Kr) mixtures, with temperatures in the range 2400-4100 K. Rate constants for dominant reactions were inferred from comparisons with computer simulations of the reactive flow
P05.57. Developing good practice guidelines in the treatment of polycystic ovary syndrome with Chinese herbal medicine: a Delphi study
Teacher Knowledge and Selection of Evidence-Based Practices: A survey study
Federal legislation and state and local policies mandate the use of evidence-based practices (EBPs) and aim to improve the quality of education for all students. Federal mandates (No Child Left Behind (NCLB) Act of 2001) coupled with teacher training requirements and the need for identifying effective practices for use with students with and without disabilities, highlight the need for teachers to not only implement EBPs but to identify such practices for implementation. The passage of NCLB marked the first time in education that the use of scientific research to inform instructional decisions was mandated
Multifluid, Magnetohydrodynamic Shock Waves with Grain Dynamics II. Dust and the Critical Speed for C Shocks
This is the second in a series of papers on the effects of dust on
multifluid, MHD shock waves in weakly ionized molecular gas. We investigate the
influence of dust on the critical shock speed, v_crit, above which C shocks
cease to exist. Chernoff showed that v_crit cannot exceed the grain
magnetosound speed, v_gms, if dust grains are dynamically well coupled to the
magnetic field. We present numerical simulations of steady shocks where the
grains may be well- or poorly coupled to the field. We use a time-dependent,
multifluid MHD code that models the plasma as a system of interacting fluids:
neutral particles, ions, electrons, and various ``dust fluids'' comprised of
grains with different sizes and charges. Our simulations include grain inertia
and grain charge fluctuations but to highlight the essential physics we assume
adiabatic flow, single-size grains, and neglect the effects of chemistry. We
show that the existence of a phase speed v_phi does not necessarily mean that C
shocks will form for all shock speeds v_s less than v_phi. When the grains are
weakly coupled to the field, steady, adiabatic shocks resemble shocks with no
dust: the transition to J type flow occurs at v_crit = 2.76 v_nA, where v_nA is
the neutral Alfven speed, and steady shocks with v_s > 2.76 v_nA are J shocks
with magnetic precursors in the ion-electron fluid. When the grains are
strongly coupled to the field, v_crit = min(2.76 v_nA, v_gms). Shocks with
v_crit < v_s < v_gms have magnetic precursors in the ion-electron-dust fluid.
Shocks with v_s > v_gms have no magnetic precursor in any fluid. We present
time-dependent calculations to study the formation of steady multifluid shocks.
The dynamics differ qualitatively depending on whether or not the grains and
field are well coupled.Comment: 43 pages with 17 figures, aastex, accepted by The Astrophysical
Journa
The Ratio of Ortho- to Para-H2 in Photodissociation Regions
We discuss the ratio of ortho- to para-H2 in photodissociation regions
(PDRs). We draw attention to an apparent confusion in the literature between
the ortho-to-para ratio of molecules in FUV-pumped vibrationally excited
states, and the H2 ortho-to-para abundance ratio. These ratios are not the same
because the process of FUV-pumping of fluorescent H2 emission in PDRs occurs
via optically thick absorption lines. Thus, gas with an equilibrium ratio of
ortho- to para-H2 equal to 3 will yield FUV-pumped vibrationally excited
ortho-to-para ratios smaller than 3, because the ortho-H2 pumping rates are
preferentially reduced by optical depth effects. Indeed, if the ortho and para
pumping lines are on the ``square root'' part of the curve-of-growth, then the
expected ratio of ortho and para vibrational line strengths is the square root
of 3, ~ 1.7, close to the typically observed value. Thus, contrary to what has
sometimes been stated in the literature, most previous measurements of the
ratio of ortho- to para-H2 in vibrationally excited states are entirely
consistent with a total ortho-to-para ratio of 3, the equilibrium value for
temperatures greater than 200 K. We present an analysis and several detailed
models which illustrate the relationship between the total ratios of ortho- to
para-H2 and the vibrationally excited ortho-to-para ratios in PDRs. Recent
Infrared Space Observatory (ISO) measurements of pure rotational and
vibrational H2 emissions from the PDR in the star-forming region S140 provide
strong observational support for our conclusions.Comment: 23 pages (including 5 figures), LaTeX, uses aaspp4.sty, accepted for
publication in Ap
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