Internationalisation in the household appliances sector in Fabriano (Italy). A case study

This paper analyses the household appliances district of Jesi-Fabriano. It shows how the internationalisation strategies of many enterprises are gradually modifying the organizational structure of the local production system. The diverse goals that have led the internationalisation processes and the strategies chosen by enterprises to effectively approach far away markets are at the core of the paper that includes a broad review of the fragmentation actions of the local enterprises. Special attention is paid to the effects of the internationalisation process on the relationships among actors along the whole filire and on the models of internal enterprise management. After an analysis of the history of the district and its current transformations, the main conclusions focus on possible scenarios regarding external and endogenous factors, on the main opportunities that enterprises should seize in order to successfully complete the ongoing internationalisation process and on the important role of local and national institutions in supporting the evolution of the model of local economic development.Internationalisation, Iinternational Fragmentation, Industrial Districts, Household Appliance Industry

Towards a GIS-based Multiscale Visibility Assessment Method for Solar Urban Planning

Urban areas are facing a growing deployment of solar photovoltaic and thermal tech-nologies on building envelopes, both on roofs and on façades, essential for the realization of the Swiss Energy Strategy 2050. This process often occurs regardless of the desirable archi-tectural integration quality in a given urban context, which depends on socio-cultural sensitivi-ty and on the visibility of the solar modules from the public space. Visibility and visual impact are recurrent decisional factors in spatial planning processes, with practical implications in-cluding touristic and real estate promotion, outdoor human comfort, way finding, public feeling of security and advertisement. In this thesis, the definition of visibility under a geometrical, physical and psycho-physiological perspective is explored, several quantitative indicators being described and test-ed. The objective is to provide a scale-dependent methodology to assess the visibility of build-ing envelope surfaces exposed to solar radiation, which could host solar modules, in urban areas. A visibility index is determined for inclusion as a variable in a multi criteria method, cover-ing areas from the strategic broad territorial scale to the district level, including neighborhoods and clusters of buildings. Accomplished research includes the estimation of public visual inter-est on the basis of crowd-sourced photographic databases, complementing geometry-based parameters such as cumulative viewsheds and solid angles. At each scale, the visibility index is systematically overlapped on an urban sensitivity layer issued from land use and on a spatial representation of the solar energy generation potential, at an appropriate level of detail. Results indicate that stakeholders can reasonably expect to harvest a serious amount of solar energy by means of building integrated solar systems without crucially affecting public perception. In the study area located in the city of Geneva (Switzerland), more than 50 m2 / building of non-visible envelope surface receiving sufficient solar radiation for an economically viable solar re-furbishment is available over half of the buildings. Solar thermal collectors or PV panels in-stalled on scarcely visible surfaces, mainly situated in courtyards, far from the streets or in deep urban canyons, could cover about 10% of the annual heating demand or alternatively, the same share of electricity needs on a district basis. At the same time, plenty of highly visible areas remain available for high-end solar deployments, which could also serve pilot and demonstration purposes

Statistical mechanics of the Cluster-Ising model

We study a Hamiltonian system describing a three-spin-1/2 cluster-like interaction competing with an Ising-like anti-ferromagnetic interaction. We compute free energy, spin correlation functions and entanglement both in the ground and in thermal states. The model undergoes a quantum phase transition between an Ising phase with a nonvanishing magnetization and a cluster phase characterized by a string order. Any two-spin entanglement is found to vanish in both quantum phases because of a nontrivial correlation pattern. Neverthless, the residual multipartite entanglement is maximal in the cluster phase and dependent on the magnetization in the Ising phase. We study the block entropy at the critical point and calculate the central charge of the system, showing that the criticality of the system is beyond the Ising universality class.Comment: To be published in Physical Review

Experimental estimation of entanglement at the quantum limit

Entanglement is the central resource of quantum information processing and the precise characterization of entangled states is a crucial issue for the development of quantum technologies. This leads to the necessity of a precise, experimental feasible measure of entanglement. Nevertheless, such measurements are limited both from experimental uncertainties and intrinsic quantum bounds. Here we present an experiment where the amount of entanglement of a family of two-qubit mixed photon states is estimated with the ultimate precision allowed by quantum mechanics.Comment: 4 pages, 3 figure

Matching visual impact, solar energy production potential and energy system optimization for an enhanced solar integration. An experience with a novel pre-design tool

This study focuses on developing a BIPV pre-design computational platform combining visual impact assessment, building simulation and energy system optimization. The outdoor exposed surface of a pavilion court building block is evaluated through a physiologically reliable indicator of visibility that determines three scenarios of PV coverage ratio. Solar PV generation and demand for heating and electricity are simulated on hourly basis. Hourly PV energy that does not match electricity needs is used to fit a multi energy hub featuring PV panels, a battery bank and an internal combustion generator. A Pareto optimization is conducted considering levelized cost of energy and grid integration level, without showing a dominant solution: this outcome encourages the development of a Multi Criteria Decision Making (MCDM) tool

Evaluation of endometrial activin A secretion for prediction of pregnancy after intrauterine insemination

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Identification of Sclerostin as a Putative New Myokine Involved in the Muscle-to-Bone Crosstalk

Bone and muscle have been recognized as endocrine organs since they produce and secrete “hormone-like factors” that can mutually influence each other and other tissues, giving rise to a “bone–muscle crosstalk”. In our study, we made use of myogenic (C2C12 cells) and osteogenic (2T3 cells) cell lines to investigate the effects of muscle cell-produced factors on the maturation process of osteoblasts. We found that the myogenic medium has inhibitory effects on bone cell differentiation and we identified sclerostin as one of the myokines produced by muscle cells. Sclerostin is a secreted glycoprotein reportedly expressed by bone/cartilage cells and is considered a negative regulator of bone growth due to its role as an antagonist of the Wnt/β-catenin pathway. Given the inhibitory role of sclerostin in bone, we analyzed its expression by muscle cells and how it affects bone formation and homeostasis. Firstly, we characterized and quantified sclerostin synthesis by a myoblast cell line (C2C12) and by murine primary muscle cells by Western blotting, real-time PCR, immunofluorescence, and ELISA assay. Next, we investigated in vivo production of sclerostin in distinct muscle groups with different metabolic and mechanical loading characteristics. This analysis was done in mice of different ages (6 weeks, 5 and 18 months after birth) and revealed that sclerostin expression is dynamically modulated in a muscle-specific way during the lifespan. Finally, we transiently expressed sclerostin in the hind limb muscles of young mice (2 weeks of age) via in vivo electro-transfer of a plasmid containing the SOST gene in order to investigate the effects of muscle-specific overproduction of the protein. Our data disclosed an inhibitory role of the muscular sclerostin on the bones adjacent to the electroporated muscles. This observation suggests that sclerostin released by skeletal muscle might synergistically interact with osseous sclerostin and potentiate negative regulation of osteogenesis possibly by acting in a paracrine/local fashion. Our data point out a role for muscle as a new source of sclerostin.Bone and muscle have been recognized as endocrine organs since they produce and secrete “hormone-like factors” that can mutually influence each other and other tissues, giving rise to a “bone–muscle crosstalk”. In our study, we made use of myogenic (C2C12 cells) and osteogenic (2T3 cells) cell lines to investigate the effects of muscle cell-produced factors on the maturation process of osteoblasts. We found that the myogenic medium has inhibitory effects on bone cell differentiation and we identified sclerostin as one of the myokines produced by muscle cells. Sclerostin is a secreted glycoprotein reportedly expressed by bone/cartilage cells and is considered a negative regulator of bone growth due to its role as an antagonist of the Wnt/β-catenin pathway. Given the inhibitory role of sclerostin in bone, we analyzed its expression by muscle cells and how it affects bone formation and homeostasis. Firstly, we characterized and quantified sclerostin synthesis by a myoblast cell line (C2C12) and by murine primary muscle cells by Western blotting, real-time PCR, immunofluorescence, and ELISA assay. Next, we investigated in vivo production of sclerostin in distinct muscle groups with different metabolic and mechanical loading characteristics. This analysis was done in mice of different ages (6 weeks, 5 and 18 months after birth) and revealed that sclerostin expression is dynamically modulated in a muscle-specific way during the lifespan. Finally, we transiently expressed sclerostin in the hind limb muscles of young mice (2 weeks of age) via in vivo electro-transfer of a plasmid containing the SOST gene in order to investigate the effects of muscle-specific overproduction of the protein. Our data disclosed an inhibitory role of the muscular sclerostin on the bones adjacent to the electroporated muscles. This observation suggests that sclerostin released by skeletal muscle might synergistically interact with osseous sclerostin and potentiate negative regulation of osteogenesis possibly by acting in a paracrine/local fashion. Our data point out a role for muscle as a new source of sclerostin