The Perceptions of Academic Librarians on Their Role in Lifelong Learning, Self-Directed Learning and Heutagogy

This paper uses a qualitative methodology to explore the perceptions of academic librarian on the definition of lifelong learning and their roles in supporting lifelong learning. Existing research on the topic was aligned to the emergent educational model of heutagogy to identify key concepts including self-directed learning, learner agency, and the impact of technology. Heutagogy is a learning model focused on self-determined learning, often in a high technology environment, for mature learners who have high degrees of agency over the entire learning process including identifying learning goals and methods, locating resources, and designing assessments. Using loosely structured interviews of academic librarians who identified instruction as a primary role in their jobs, this exploratory project identified key conceptual themes in defining lifelong learning around the personal attributes of a lifelong learner, the degree of educational formality, and the learner’s reason for engaging in lifelong learning. In support of lifelong learning, these academic librarians explored the relation of lifelong learning to specific learning goals they have for students but also described various structural limitations. Several overlapping themes between lifelong learning in academic libraries and heutagogy were found without firmly suggesting it as an appropriate model to apply to lifelong learning in academic library contexts

Implementing Low Barrier Cards

Randy Gatley and Jacqueline Garden described the specifications and design process for two low barrier card models as well as early implementation issues and plans for future assessment

Lo scambio emotivo-interattivo fra bambino con sindrome di Down e genitori

Il presente lavoro di ricerca si propone di studiare le strategie di regolazione affettiva dei bambini con Sindrome di Down (Down Syndrome DS) durante momenti di gioco videoregistrati con i genitori (madri e padri). Metodologia: Sono stati osservati 20 bambini con DS in interazione rispettivamente con madre e padre durante momenti di gioco a casa. Gli scambi interattivi sono stati valutati attraverso le Scale di Valutazione Interattiva Caregiver-Bambino (Speranza, Trentini, Celani, 2010), al fine di esplorare le eventuali differenze nella qualità della relazione diadica. Le competenze emozionali dei bambini sono state osservate con le scale di Sviluppo Socioemozionale (Ferri, Carleschi, Orsini, 2010). I bambini con DS dimostrano una buona competenza nelle diverse relazioni, con un’espressività orientata al versante delle emozioni positive e impegno nel rapporto diadico con i genitori.The present research study aims at investigating the strategies for emotional regulation of children with Down Syndrome (DS) during videorecorded playtime with their parents (mothers and fathers). The methodology consisted in the observation of 20 children with DS in their interaction with both mothers and fathers, one parent per time, during play sessions at home. The interactional exchanges have been evaluated by means of the Interactional Rating Scales Caregiver-Children (Speranza, Trentini, Celani, 2010), with the purpose of exploring the possible differences in the quality of the dyadic relationship. The children's emotional competences have been observed using the Socioemotional Development Scales (Ferri, Carleschi, Orsini, 2010). Children with DS have shown dedication in the relationship with parents and good abilities in the interactions, with their expressivity mainly oriented towards the posivite emotion side. Keywords: Down Syndrome; development; interaction with parents

New sulfurated derivatives of cinnamic acids and rosmaricine as inhibitors of STAT3 and NF-kappa B transcription factors

A set of new sulfurated drug hybrids, mainly derived from caffeic and ferulic acids and rosmaricine, has been synthesized and their ability to inhibit both STAT3 and NF-kappa B transcription factors have been evaluated. Results showed that most of the new hybrid compounds were able to strongly and selectively bind to STAT3, whereas the parent drugs were devoid of this ability at the tested concentrations. Some of them were also able to inhibit the NF-kappa B transcriptional activity in HCT-116 cell line and inhibited HCT-116 cell proliferation in vitro with IC50 in micromolar range, thus suggesting a potential anticancer activity. Taken together, our study described the identification of new derivatives with dual STAT3/NF-kappa B inhibitory activity, which may represent hit compounds for developing multi-target anticancer agents

NPY Levels In Type 1 Diabetic Men of Different Duration.

Background: The aim of the present study was to evaluate whether the different duration of type 1 diabetes mellitus influences basal NPY secretion. Design: The NPY concentrations were measured in sixty-eight men with insulin-dependent diabetes mellitus (IDDM) (duration: group 1 (n.21) <5 years (range 2-4 years); group 2 (n.24) >5 years and <10 years (range: 6-9 years); group 3 (n.29) >10 years (range: 11-14 years)) and in age matched normal control subjects (n. 30). Results: The NPY levels were significantly lower in group 3 than in group 2 and 1 and in the control group, in group 2 than in group 1 and in the control group and in group 1 than control group. Conclusion: These results support the view that the duration of diabetes may have a modulatory role in the decreased basal NPY secretion observed in diabetics

Hepatitis E Virus Detection in Hunted Wild Boar Liver and Muscle Tissues in Central Italy

In different European countries, including Italy, hepatitis E virus (HEV) has been recognized as an emerging public health concern. Humans are infected through the orofecal route by the ingestion of contaminated uncooked or undercooked animal-origin foodstuffs. Wild boars (Sus scrofa) have gained a crucial role as viral reservoirs. HEV-3 is the most frequently identified genotype from hunted wild boar liver and muscle tissues. The Marche region, more specifically Ascoli Piceno province, is characterized by a rooted hunting tradition and related product consumption. In this research study, 312 liver and 296 muscle specimens were screened using biomolecular assays, and HEV RNA was detected from 5.45% and 1.35% of liver and muscle samples, respectively. Phylogenetic analysis revealed that positive animals were infected by genotype 3 subtype c. Based on the environmental pathogen characteristics, HEV has also evolved to guarantee its survival in a wild environment. Therefore, wild boars and ruminants have a key role in its persistence. Epidemiological data regarding HEV circulation have resulted as necessary, and biomolecular analysis represents an important means of monitoring and establishing preventive measures. A multidisciplinary approach could provide a wide perspective regarding HEV and infectious implications on human, animal, and environmental health

Intradiaphragmatic abscesses in a wild boar (Sus scrofa): Inspective implications based on anatomopathological evidences

The intradiaphragmatic localization of an abscess is rarely described in humans and in other animal domestic and wild species, and can be caused by penetrative traumas (i.e., firearm injuries). Here we describe two intradiaphragmatic abscesses in a hunted adult male wild boar (Sus scrofa) pluck, associated with adhesion phenomena with the contiguous anatomical structures (pleural, phrenic, and glissonian serosas) and observed during the post mortem inspection, in accordance with the Reg. EU 627/2019. One of these lesions also presented a phreno-abdominal fistula. We found in cytopathological evaluation of the neoformations' content the presence of spheroidal bacterial soma, characterized by linearly concatenated "Streptococcus-like" aggregation pattern. Furthermore, microbiological assays revealed a polymicrobial pattern characterized by the presence of telluric microorganisms, some of which have a marked pyogenic action (Streptococcus suis type I, Sphingomonas paucimobilis, Carnobacterium divergens, and Lactobacillus sakei). Our results and collected evidence demonstrate the pathogenetic hypothesis of bacterial contamination secondary to penetrative trauma caused by a not-mortal projectile's wound, defining the inspective behaviour according to the cogent legislation. These lesions, in the reason of their potential relation to toxemia, bacteremia and septicemia phenomena, represent a sanitary risk that impose, from a normative point of view, the total condemnation of the carcass. These inspective implications, originating from the observation and interdisciplinary description of the anatomopathological and microbiological features of the lesions, are directly projected on the normative scenario, providing useful elements to guarantee the health of the consumer

Vitamin E Supplementation Reduces Plasma Vascular Cell Adhesion Molecule-1 and von Willebrand Factor Levels and Increases Nitric Oxide Concentrations in Hypercholesterolemic Patients

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Efficient non-degenerate two-photon excitation for fluorescence microscopy

Non-degenerate two-photon excitation (ND-TPE) has been explored in two-photon excitation microscopy. However, a systematic study of the efficiency of ND-TPE to guide the selection of fluorophore excitation wavelengths is missing. We measured the relative non-degenerate two-photon absorption cross-section (ND-TPACS) of several commonly used fluorophores (two fluorescent proteins and three small-molecule dyes) and generated 2-dimensional ND-TPACS spectra. We observed that the shape of a ND-TPACS spectrum follows that of the corresponding degenerate two-photon absorption cross-section (D-TPACS) spectrum, but is higher in magnitude. We found that the observed enhancements are higher than theoretical predictions.Published versio

Discontinuously supervised aerobic training vs. physical activity promotion in the self-management of type 2 diabetes in older Italian patients: design and methods of the 'TRIPL-A' randomized controlled trial

Physical activity (PA) has health benefits for people with type 2 diabetes (T2D). Indeed, regular PA is considered an important part of any T2D management plan, yet most patients adopt a sedentary lifestyle. Exercise referral schemes (ERS) have the potential to effectively promote physical activity among T2D patients, and their effectiveness may be enhanced when they are supported by computer-based technologies. The 'TRIPL-A' study (i.e., a TRIal to promote PhysicaL Activity among patients in the young-old age affected by T2D) aims to assess if realizing an innovative ERS, based on a strong partnership among general practitioners, specialist physicians, exercise specialists, and patients, and supported by a web-based application (WBA), can effectively lead sedentary older T2D patients to adopt an active lifestyle