31 research outputs found
Relación de los parámetros de hiperfibrinólisis con el riesgo transfusional y trombótico en las fracturas de cadera con fragilidad
La fractura de cadera por fragilidad en ancianos osteoporóticos supone un grave problema en aumento como consecuencia directa del incremento de la esperanza de vida. Es una patología que por ello acarrea una importante morbimortalidad así como costes elevados en su tratamiento. Este estudio se centra principalmente en el riesgo hemorrágico y riesgo trombótico que supone, usando diversos factores para comprobar si verdaderamente funcionan como predictores de hemorragia o trombosis venosa profunda durante el proceso. Los destacables son el dímero D, hemoglobina en distintos puntos del proceso, escalas de HAS-BLED y Caprini, demora quirúrgica y tipo de fractura y cirugía, de los cuales todos ellos se han comportado tal y como se había predicho.<br /
Proposal to calculate the maximun elasticity index value of lower members
En el presente artículo se ha calculado el índice de elasticidad máxima de los miembros inferiores en una población de 24 sujetos (19.6±0.3 años, 1.73±0.6 m, 71.7±1.2 Kg), estudiantes de la titulación de Magisterio de Educación Física.
Para calcular el índice de elasticidad máxima de miembros inferiores hemos utilizado el test de Bosco y una nueva propuesta ideada por los autores del presente artículo denominada “test de salto de ángulo libre”. El test consiste en obtener el ángulo óptimo de flexión de rodillas a partir del Counter Movement Jump mediante análisis de video para posteriormente realizar el squat jump y así calcular el índice de elasticidad máximo.
Los resultados indican que los sujetos consiguen mejores marcas y con un mayor rango utilizando la prueba de ángulo libre con respecto a la de Bosco. Se ha obtenido una correlación significativa (p<0.01) entre el índice de elasticidad calculado a partir del test de Bosco y el calculado a partir del test de ángulo libre
Impact of the COVID-19 pandemic on tuberculosis management in Spain
Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Impacte; TuberculosiCoronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Impacto; TuberculosisCoronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Impact; TuberculosisBackground
The impact of COVID-19 on the diagnosis and management of tuberculosis (TB) patients is unknown.
Methods
Participating centres completed a structured web-based survey regarding changes to TB patient management during the COVID-19 pandemic. The study also included data from participating centres on patients aged ≥18 diagnosed with TB in 2 periods: March 15 to June 30, 2020 and March 15 to June 30, 2019. Clinical variables and information about patient household contacts were retrospectively collected.
Results
A total of 7 (70%) TB units reported changes in their usual TB team operations. Across both periods of study, 169 patients were diagnosed with active TB (90 in 2019, 79 in 2020). Patients diagnosed in 2020 showed more frequent bilateral lesions in chest X-ray than patients diagnosed in 2019 ( P = 0.004). There was a higher percentage of latent TB infection and active TB among children in households of patients diagnosed in 2020, compared with 2019 ( P = 0.001).
Conclusions
The COVID-19 pandemic has caused substantial changes in TB care. TB patients diagnosed during the COVID-19 pandemic showed more extended pulmonary forms. The increase in latent TB infection and active TB in children of patient households could reflect increased household transmission due to anti-COVID-19 measures.This research did not receive any specific grant from funding agencies in the public, commercial or not-for-profit sectors.MLA was supported by a postdoctoral grant “Rio Hortega” and ASM was supported by a postdoctoral grant “Juan Rodés” (JE18/00022) from the Instituto de Salud Carlos III through the Spanish Ministry of economy and competitiveness
Efecto de la densidad de población y la fertilización sobre la productividad del agua y rendimientos de híbridos de maíz en el Valle de México
La insuficiencia alimentaria en maíz, la crisis de agua y fertilizantes a nivel mundial, demandan incrementar la eficiencia en el uso de recursos incrementando o conservando la producción. El objetivo del trabajo fue definir la respuesta de cuatro híbridos de maíz blanco (Tlaoli Puma, Atziri Puma, H-49 AE y H-47 AE) en dos ambientes con dos densidades de población y dos dosis de fertilización y testigo sin fertilizar. Como arreglo factorial, en los ambientes Cuautitlán (FESC-UNAM) y Texcoco (CEVAMEX), Estado de México, se evaluaron los híbridos con dos densidades de siembra (D1=75 000; D2=90 000 plantas ha-1) y tres tratamientos de fertilización (F1=160-80-00, F2=120-40-00, F3=00-00-00). El experimento en bloques completos al azar se conformó con los tratamientos y la combinación de los factores 2×4×2×3 establecidos en tres repeticiones. Las medias se compararon con el método Tukey (P < 0.05). Para el rendimiento de grano y productividad del agua, en la FESC-UNAM con menor agua total, resultaron de 5.96 Mg ha-1 y 1.29 kg m-3 en CEVAMEX 4.76 Mg ha-1 y 0.5 kg m-3; el híbrido Atziri Puma sobresalió con 6.52 Mg ha-1 y 1.09 kg m-3. No se observó efecto significativo de la densidad de siembra y D1 resultó con 5.32 Mg ha-1 y 0.9 kg m-3 contra D2 con 5.4 Mg ha-1 y 0.9 kg m-3. En la fertilización, F1 fue superior estadísticamente con 5.64 Mg ha-1 y 0.94 kg m-3, pero no hubo diferencia entre F2 (5.24 Mg ha-1 y 0.88 kg m-3) y el control F3 (5.19 Mg ha-1 y 0.87 kg m-3). Se presentó interacción de los ambientes con los híbridos y destacó el híbrido Atziri Puma en la FESC-UNAM (7.3 Mg ha-1 y 1.58 kg m-3). El sitio FESC-UNAM tiene potencial productivo en condiciones de temporal con los híbridos Puma e INIFAP
Adherence and Toxicity during the Treatment of Latent Tuberculous Infection in a Referral Center in Spain
Latent tuberculosis infection; Toxicity; Tuberculosis screeningInfecció tuberculosa latent; Toxicitat; Cribratge de tuberculosiInfección tuberculosa latente; Toxicidad; Cribado de tuberculosisThe screening and treatment of latent tuberculosis infection (LTBI) in countries with a low incidence of TB is a key strategy for the elimination of tuberculosis (TB). However, treatment can result in adverse events (AEs) and have poor adherence. This study aimed to describe treatment outcomes and AEs for LTBI patients at two departments in Vall d'Hebron University Hospital in Barcelona, Spain. A retrospective study was conducted on all persons treated for LTBI between January 2018 and December 2020. Variables collected included demographics, the reason for LTBI screening and treatment initiation, AEs related to treatment, and treatment outcome. Out of 261 persons who initiated LTBI treatment, 145 (55.6%) were men, with a median age of 42.1 years. The indications for LTBI screening were household contact of a TB case in 96 (36.8%) persons, immunosuppressive treatment in 84 (32.2%), and recently arrived migrants from a country with high TB incidence in 81 (31.0%). Sixty-three (24.1%) persons presented at least one AE during treatment, and seven (2.7%) required definitive discontinuation of treatment. In the multivariate analysis, AE development was more frequent in those who started LTBI treatment due to immunosuppression. Overall, 226 (86.6%) completed treatment successfully. We concluded that LTBI screening and treatment groups had different risks for adverse events and treatment outcomes. Persons receiving immunosuppressive treatment were at higher risk of developing AEs, and recently arrived immigrants from countries with a high incidence of TB had greater LTFU. A person-centered adherence and AE management plan is recommended.A.M.L. was supported by a postdoctoral grant “Juan Rodés” (JE21/00027) from the Instituto de Salud Carlos through the Ministry of Economy and Competitiveness, Spain
A longitudinal prospective study of active tuberculosis in a Western Europe setting : insights and findings
This study investigates the potential of inflammatory parameters (IP), symptoms, and patient-related outcome measurements as biomarkers of severity and their ability to predict tuberculosis (TB) evolution. People with TB were included prospectively in the Stage-TB study conducted at five clinical sites in Barcelona (Spain) between April 2018 and December 2021. Data on demographics, epidemiology, clinical features, microbiology, and Sanit George Respiratory Questionnaire (SGRQ) and Kessler-10 as Health-Related Quality of Life (HRQoL) were collected at three time points during treatment. C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), neutrophil/lymphocyte, and monocyte/lymphocyte ratios (NLR and MLR), complement factors C3, C4, and cH50, clinical and microbiological data, and HRQoL questionnaires were assessed at baseline, 2 months, and 6 months. Their ability to predict sputum culture conversion (SCC) and symptom presence after 2 months of treatment was also analysed. The study included 81 adults and 13 children with TB. The CRP, ESR, NLR, and MLR values, as well as the presence of symptoms, decreased significantly over time in both groups. Higher IP levels at baseline were associated with greater bacillary load and persistent symptoms. Clinical severity at baseline predicted a delayed SCC. Kessler-10 improved during follow-up, but self-reported lung impairment (SGRQ) persisted in all individuals after 6 months. IP levels may indicate disease severity, and sustained high levels are linked to lower treatment efficacy. Baseline clinical severity is the best predictor of SCC. Implementing health strategies to evaluate lung function and mental health throughout the disease process may be crucial for individuals with TB. The online version contains supplementary material available at 10.1007/s15010-024-02184-2
Tecnologías de la comunicación para la divulgación científica y la mejora docente
El empleo de redes sociales se ha convertido en los últimos años en una actividad cotidiana para la gran mayoría de jóvenes y, por ende, para los universitarios. Muchos docentes e instituciones están incorporado las redes sociales a sus estrategias de enseñanza y difusión de contenidos al tratarse de un espacio idóneo para intercambiar información y el conocimiento de una forma rápida, sencilla y cómoda. Este trabajo presenta el proyecto docente llevado a cabo en el Grado de Lingüística y Lenguas Aplicadas de la Universidad de Cádiz durante el curso 2017‐2018 con la finalidad de mejorar el conocimiento, expectativas y motivación del alumnado mediante el uso de nuevos medios de comunicación social: twitter, Facebook, Instagram, youtube y mailing lists
Introducció a les Xarxes Telemàtiques: problemes amb solució
Col·lecció de problemes resolts d'IXT (Introducció a les Xarxes Telemàtiques) amb solució, 1er curs dels graus de l'ETSETB.2022/20232n quadrimestr
Introducció a les Xarxes Telemàtiques: problemes amb solució
Col·lecció de problemes resolts d'IXT (Introducció a les Xarxes Telemàtiques) amb solució, 1er curs dels graus de l'ETSETB2022/20232n quadrimestr
Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2
The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality