I Diretrizes do Grupo de Estudos em Cardiogeriatria da Sociedade Brasileira de Cardiologia

O idoso apresenta características próprias na manifestação das doenças, na resposta à terapêutica e no efeito colateral dos medicamentos. Constitui um grupo de maior risco para o aparecimento das doenças degenerativas, em geral, e cardiovasculares, em particular, além de apresentar maior número de comorbidades

Genome-wide identification, classification and transcriptional analysis of nitrate and ammonium transporters in Coffea

Abstract Nitrogen (N) is quantitatively the main nutrient required by coffee plants, with acquisition mainly by the roots and mostly exported to coffee beans. Nitrate (NO3–) and ammonium (NH4+) are the most important inorganic sources for N uptake. Several N transporters encoded by different gene families mediate the uptake of these compounds. They have an important role in source preference for N uptake in the root system. In this study, we performed a genome-wide analysis, including in silico expression and phylogenetic analyses of AMT1, AMT2, NRT1/PTR, and NRT2 transporters in the recently sequenced Coffea canephora genome. We analyzed the expression of six selected transporters in Coffea arabica roots submitted to N deficiency. N source preference was also analyzed in C. arabica using isotopes. C. canephora N transporters follow the patterns observed for most eudicots, where each member of the AMT and NRT families has a particular role in N mobilization, and where some of these are modulated by N deficiency. Despite the prevalence of putative nitrate transporters in the Coffea genome, ammonium was the preferential inorganic N source for N-starved C. arabica roots. This data provides an important basis for fundamental and applied studies to depict molecular mechanisms involved in N uptake in coffee trees

Prevalence, awareness, and treatment of hypertension in patients with type 1 diabetes : a nationwide multicenter study in Brazil

Objective.This study evaluated the prevalence, awareness, and type of treatment for hypertension in Brazil in patients with type 1 diabetes (T1D). Methods.This was a cross-sectional,multicenter study that was conducted fromDecember 2008 to December 2010 in 28 public clinics located in 20 Brazilian cities. Results. A total of 3,591 patients were studied, 56% female, average age 21.2 ± 11.7 years, with a median duration of diabetes 9.6 ± 8.1 years. Blood pressure levels were available for a total of 3,323 patients and 689 (19.2%) patients were hypertensive. Hypertensive patients were older, exhibited longer duration of diabetes, and had higher body mass index (BMI), total cholesterol, triglycerides, and LDL-C values ( < 0.001, for all comparisons), but only 370 (53.7%) received treatment. Patient awareness of hypertension was documented in 453 (65.5%) patients. However, only 76 (22.9%) of the treated patients attained the target systolic (sBP) and diastolic blood pressures (dBP). Conclusions. Our results demonstrate that a large number of T1D patients with hypertension do not receive appropriate treatment; few of the treated T1D patients achieved the target sBP and dBP values. Greater attention should be paid to blood pressure evaluation, hypertension diagnosis, and treatment of T1D patients in Brazil

Proportion of tuberculosis and nontuberculous mycobacterial lung disease by age group - State of Para, Brazil, 2010–2011.

<p>Proportion of tuberculosis and nontuberculous mycobacterial lung disease by age group - State of Para, Brazil, 2010–2011.</p

Summary of distinguishing features of NTM patients.

<p>Summary of distinguishing features of NTM patients.</p

Individuals who met the ATS microbiological criteria for nontuberculous mycobacterial pulmonary disease from Para State, Brazil.

<p>Note: F (female); M (male); AFB (acid fast bacilli); − (negative); + (positive); BAL (bronchoalveolar lavage); GL (gastric lavage); TB (tuberculosis); COPD (chronic obstructive pulmonary disease); MSC (<i>Mycobacterium simiae</i> complex).</p

Representative image showing lung damage in a patient with nontuberculous mycobacterial diseases.

<p>A 69-years-old woman with <i>Mycobacterium abscessus</i> pulmonary disease. (A and B) High resolution computed tomography (HRCT) of the chest obtained at level of upper lobes showing multiples cavities in the right upper lobe and centrilobular nodules. It is also possible to observe bronchiectasis in left upper lobe (arrow). (C) Tree-in-bud pattern. (D) Presence of bronchiectasis in middle lobe. Also note centrilobular nodules at right lower lobe.</p

Clinical and images findings for some nontuberculous mycobacterial pulmonary infected patients from Para State, Brazil.

<p>Note: RUL (right upper lobe); LUL (left upper lobe); RML (right middle lobe); RLL (right lower lobe); LLL (left lower lobe).</p

American Thoracic Society diagnostic criteria on nontuberculous mycobacterial pulmonary disease.

<p>Note: Table adapted from Griffith et al. <a href="http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0002340#pntd.0002340-Griffith1" target="_blank">[12]</a>.</p