Thermal FE analysis of a one side brake block test equipment (Part 1)

The present paper includes the first part of an investigation of the complex braking process during the braking of railway vehicles, using transient thermal FE models with temperature dependent material properties. In the development of the geometric model, efforts were made to take the test equipment into consideration to as great an extent as possible, enabling the investigation through time of the thermal behaviour of the entire apparatus. Bearing houses were modelled in a simplified manner and contact heat resistances were applied for bearings. Numerical calculations were validated by measurement data. The correspondence of the results applying the two methods was acceptable

Extension of pit corrosion effect on pipelines

This article deals with the analysis of effect of wall thinning on pipelines as a local perturbation caused by inner or outer corrosion failure. The main aims of the investigation were to analyse the interaction of the pit corrosion defects and to determine the least lengths of FEA (Finite Element Analysis) models where the boundary conditions do not influence the results. The effects of corrosion pits were investigated by the help of FEA method and the results were validated based on an analytical calculation method

Shortest path discovery of complex networks

In this paper we present an analytic study of sampled networks in the case of some important shortest-path sampling models. We present analytic formulas for the probability of edge discovery in the case of an evolving and a static network model. We also show that the number of discovered edges in a finite network scales much slower than predicted by earlier mean field models. Finally, we calculate the degree distribution of sampled networks, and we demonstrate that they are analogous to a destructed network obtained by randomly removing edges from the original network.Comment: 10 pages, 4 figure

Az ""alacsony T3 szindróma"" kialakulásáért felelős központi idegrendszeri szabályozó mechanizmusok tanulmányozása patkányban = Central regulatory mechanisms involved in the development of the 'low T3 syndrome'

A pályázat fő célja az éhezés és fertőzés hatására kialakuló centrális hipotiroidizmus kialakulásáért felelős központi idegrendszeri szabályozó mechanizmusok tanulmányozása volt. Kimutattuk, hogy a leptin, inzulin és glükóz eltérő hatást fejt ki az arcuatus idegmag sejtjeire és csak a leptin képes kivédeni az éhezés hatására kialakuló centrális hipotiroidizmust. Leírtuk, hogy az AGRP TRH idegsejtekre kifejtett gátló hatását elsősorban a 4-es típusú melanokortin receptor (MC4-R) közvetíti. Igazoltuk, hogy a PVN MC4-R tartalmú idegsejtjein a legtöbb AGRP tartalmú terminális közelében nem figyelhetők meg ?-MSH-tartalmú végződések, valószínűsítve, hogy az AGRP a PVN-ben inverz agonistaként hathat. Leírtuk, hogy LPS kezelés a pajzsmirigyhormonok szintjének változásától függetlenül D2 aktivitás fokozódást eredményez a mediobazális hipotalamuszban a tanycytákban. Továbbá azonosítottuk a D2 promoter NF-kB kötőhelyét. Ezek alapján feltételezzük, hogy LPS hatására a megemelkedett D2 aktivitás az eredményezett lokális hipertiroidizmus révén hozzájárul a TRH idegsejtek gátlásához. | The long term goal of the proposed studies was the examination of the hypothalamic regulatory systems involved in the development of the central hypothyroidism induced by fasting or infection. We have described that leptin, insulin and glucose have different effects on the neurons of the arcuate nucleus. In addition, only leptin is able to reverse the fasting induced changes of the hypothalamic-pituitary-thyroid axis. We have demonstrated that the effect of AGRP on the hypophysiotropic TRH neurons is primarily mediated by the melanocortin 4 receptor (MC4-R). In addition, we have provided evidence that ?-MSH-containing varicosities are not present in the proximity of the AGRP terminals on the surface of the MC4-R-producing cells in the PVN, suggesting that AGRP acts as an inverse agonist in the PVN. We have demonstrated that LPS induces an increase of D2 activity in the tanycytes of the mediobasal hypothalamus. These changes are independent from the changes of the peripheral thyroid hormone level. Furthermore, we have identified the NF-kB binding cite of the D2 promoter. Based on these data, we hypothesize that the LPS induced increase of D2 activity results in a local hyperthyroidism in the PVN that contribute to the LPS induced inhibition of the hypophysiotropic TRH neurons

EGF regulates tyrosine phosphorylation and membrane-translocation of the scaffold protein Tks5

Background: Tks5/FISH is a scaffold protein comprising of five SH3 domains and one PX domain. Tks5 is a substrate of the tyrosine kinase Src and is required for the organization of podosomes/invadopodia implicated in invasion of tumor cells. Recent data have suggested that a close homologue of Tks5, Tks4, is implicated in the EGF signaling.Results: Here, we report that Tks5 is a component of the EGF signaling pathway. In EGF-treated cells, Tks5 is tyrosine phosphorylated within minutes and the level of phosphorylation is sustained for at least 2 hours. Using specific kinase inhibitors, we demonstrate that tyrosine phosphorylation of Tks5 is catalyzed by Src tyrosine kinase. We show that treatment of cells with EGF results in plasma membrane translocation of Tks5. In addition, treatment of cells with LY294002, an inhibitor of PI 3-kinase, or mutation of the PX domain reduces tyrosine phosphorylation and membrane translocation of Tks5.Conclusions: Our results identify Tks5 as a novel component of the EGF signaling pathway. © 2013 Fekete et al.; licensee BioMed Central Ltd