The Relationship between Sex Roles and Childbearing Motivation in Fertile Women, Iran

Introduction: This study was conducted to determine the relationship between sex role and women's childbearing motivation.Methods: In this study 841 married female participants lived in urban society of Mashhad were recruited based on a multistage sampling from a variety of settings. Data was gathered using Childbearing Questionnaire (CBQ) and brief form of Bem sex role questionnaire. Analyzed using Pearson correlation coefficient, multiple regression test and independent t-test.Results: Feminine sex role was in significant relationship with positive childbearing motivation (p=.001). Masculine sex role have no relationship with both childbearing motivations. ANOVA showed a difference between the motivations in four groups of participants divided based on sex role scores. LSD test shows that positive motivation in android (p=.013) and masculine (p=.012) groups were significantly less than feminine group. Negative childbearing motivations in feminine group was less than in UN-differentiate group (p=.014). Conclusion: Multiple regression analysis show that positive motivation was in relationship with the feminine sex role and reverse relationship with marriage age. Reproductive health policy makers and family planning counselors can apply study findings in order to plan perfect programs to direct proper fertility behaviors in the society

N,N′-Dicyclo­hexyl-N′′,N′′-dimethyl­phospho­ric triamide

In the title compound, C14H30N3OP, both cyclo­hexyl groups adopt chair conformations with the NH unit in an equatorial position. The P atom adopts a slightly distorted tetra­hedral environment. In the (CH3)2NP(O) unit, the O—P—N—C torsion angles, showing the orientations of the methyl groups with respect to the phosphoryl group, are −166.6 (3) and 34.6 (4)°. The O atom of the P=O group acts as a double hydrogen-bond acceptor and is involved in two different inter­molecular N—H⋯OP hydrogen bonds, building R 2 2(8) rings that are further linked into chains running parallel to the b axis

The effectiveness and safety of Iranian herbal medicines for treatment of premenstrual syndrome: A systematic review

Objective: Premenstrual syndrome (PMS) is one of the most common problems among women of reproductive age. The popularity of complementary/alternative therapies has grown in recent years, and these treatments have been more commonly used by women (48.9%) than men (37.8%). The aim of this systematic review was to assess effectiveness and safety of Iranian herbal medicines for treatment of premenstrual syndrome. Methods: PubMed, Scopus, Cochrane, and Google Scholar were searched along with SID, Magiran and Irandoc up to Dec 2017. Inclusion criteria consist of Iranian, published, randomized controlled trials (RCTs) using Iranian herbal medicine for treatment of reproductive age women with PMS. Eventually Eighteen RCTs met the inclusion criteria. Results: Overall, studies have shown that Vitex agnuscastus, Hypericum perforatum, Matricaria chamomilla, saffron, Curcumin, Melissa officinalis, Zataria multiflora,Wheat Germ Extract, Echinophora platyloba, Foeniculum vulgare, Valerian root extract, Citrus sinensis, Zingiber officinale andFlax seed might alleviate symptoms of PMS. Conclusion: This research demonstrated efficacy and safety of Iranian herbal medicines in alleviating PMS. Therefore, herbal medicine can be regarded as an alternative treatment for women suffering from PMS

Outcome of Vaginal Progesterone as a Tocolytic Agent: Randomized Clinical Trial

Vaginal progesterone has a potential beneficial effect in postponing of preterm labor by suppression of prostaglandins cascades. Although different studies evaluated the use of progesterone for preterm birth, the exact effect of which on prolongation of pregnancy remains unclear. Seventy two women who underwent preterm labor were managed by magnesium sulfate. Then they were randomly assigned to continue pregnancy either by applying vaginal progesterone (400 mg) until delivery or without using any drug. Gestational age mean at the time of delivery (P = 0.039) and postponing delivery mean time (P = 0.048) were significantly higher in progesterone group. Comparison of neonatal outcomes between two groups of patients showed meaningful benefits of progesterone in increasing of neonatal weight, reduction of low birth weight babies, and lowing neonate admitted in NICU

Islamic Guidelines in Promoting Fertility: A Narrative Reviewa

Population is most important asset in each country. Fertility is one of the main issues in demography. It is also an important element of population growth during recent years. Iran’s population has been experiencing important changes in its age structure due to the continuous decline in fertility. Presently, Iran is one of the countries that has low fertility rates. These changes, on the one hand, bear substantial considerations in terms of economic, social, policy and planning making and planning strategies, on the other hand religious government cannot stay indifferent to the religious priorities in the social, economic and family planning, thus, statesmen need to be aware of this phenomenon. This study intends to introduce Quranic guidelines and Islamic traditions concerned with fertility. In this narrative review, documents without a time limit and using the keywords Quran, Fertility, Population, Islam and Iran, alone or in combination in the alone or in combination in the Persian and English databases were searched. Also fully reviewed all 114 Surahs and other religious sources to find the verses and narrations and hadiths specifically referring to the fertility. The documents were summarized and critiqued. In Quran, there are various verses which point to infertility and human reproduction. in Surahs Al-Shura, Al-Nuh, Al-Nour , Al-Anam, Al- Nisa, Al- Tawbah, Al- Ahzab, Al- Baqarah, Al- Qiyamat, Al- Tariq, Al- Fatir, Al- Qasas, Al- Momen, Al- Ra’d, Al- Anbiya, Al- Talaq, l- Al-Imran, Al- An’am, Al- Isra, Al- Mursalat. Since being ignorant to the issue of fertility in the current situation in Iran can lead to a decrease in political, social, and economic power, it is rational to pay special attention to fertility based on the mentioned cases, and especially, the importance of the concept of fertility in the Quran and Islamic sources

The impact of irritable bowel syndrome on health-related quality of life in women with polycystic ovary syndrome

Background: The objectives of this study were to compare the prevalence and quality of life (QOL) of irritable bowel syndrome (IBS) in women with polycystic ovary syndrome (PCOS) compared with healthy women. Methods: This was a case-control study of 201 women recruited at an infertility clinic in Iran. The control group were healthy women (n = 100) and the comparison group, women with PCOS (n = 101). Data were collected by clinical Rome III criteria to determine the IBS, Bristol scale for stool consistency and IBS QOL. Results: The reporting of IBS symptoms were higher in PCOS (20.7%) than control group (11%) (P = 0.05). The IBS QOL score in the IBS + PCOS group was lower than other groups (IBS+ non PCOS, non IBS + PCOS, non IBS+ non PCOS; scores in food avoidance and worries about health domains were significant (P < 0.01). Conclusions: We conclude that having PCOS and an increased level of LH/FSH tends to cause IBS symptoms. IBS + PCOS women experience significant impaired quality of life scores particularly in relation to worries about health and food avoidance. These results offer further insights into IBS in PCOS women and their functional status and wellbeing

Phytochemical properties and antiviral effect of green tea (Camellia sinensis) extract on adenovirus in vitro

Background and aims: The lack of effective antiviral drugs for adenoviruses is one of the most important problems in this area. The aim of this study was to investigate the phytochemical properties and antiviral effect of the green tea extract (GTE) on adenovirus in HEp2 cells in vitro. Methods: In this experimental study, dried leaves of green tea were extracted by maceration. Total phenolic content (TPC), total flavonoid content (TFC), and antioxidant capacity of the extract were measured by Folin-Ciocalteu, aluminum chloride, and 2,2-diphenyl-1- picrylhydrazyl (DPPH) colorimetric methods, respectively. The amounts of some phenolic compounds in the extract were also determined using high-performance liquid chromatography. The toxicity of the extract on Hep2 cells and antiviral activity of the extract on adenovirus were assessed by the MTT colorimetric method. The half-maximum cytotoxicity concentration (CC50) and the 50 inhibitory concentration (IC50) of the extract were calculated as well. Results: Phytochemical investigations showed that the IC50 of DPPH radical was 42.1 ± 3.2 μg/mL compared with butylated hydroxytoluene (IC50 of 33.5 ± 3.67 μg/mL). The TPC and TFC of the extract were 74.2 mg GAE/g and 16.3 mg RE/g of the dry extract, respectively. The extract demonstrated the highest amounts of syringic acid, gallic acid, 3,4-dihydroxybenzoic acid, and rutin levels (67.27, 20.12, 7.39, and 2.97 mg/g DW, respectively). Based on the results of cell culture, the CC50 and IC50 of GTE were 103.3 μg/mL and 25.16 μg/mL, respectively. Conclusion: GTE with phenolic and flavonoid compounds can exert dose-dependent inhibitory effects on adenoviruses

Coronavirus disease 2019 (COVID-19) manifestations during pregnancy in all three trimesters: A case series

Background: Coronavirus disease 2019 (COVID-19) pandemic has raised concerns about the susceptibility amongst different groups of the population. Pregnant women are one such group. This study was conducted to investigate the effect of COVID-19 on pregnancy and maternal/neonatal outcomes. Case presentation: This case series was conducted on 16 pregnant women with COVID-19 from March 21 to May 11, 2020. Clinical characteristics, pregnancy complications, medication used, maternal/neonatal outcomes, and fatality rate were investigated through this study. The mean age of the patients was 30.06 yrs. Patients from all three trimesters were included (1 in first, 5 in second, and 10 in the third trimesters). The most common clinical symptoms were shortness of breath (n = 10), dry cough (n = 10), myalgia (n = 8), and chills (n = 7). Also, three cases had papulosquamous skin lesions with fissuring. The most common laboratory results were leukocytosis (n = 8), increased liver enzymes (n = 6), elevated CRP (n = 5), and thrombocytopenia (n = 4). There was one case of maternal mortality, five of premature labor pain (PLP), two of preeclampsia, and two of placenta accreta. Twelve pregnancies were terminated (nine cesarean sections, three vaginal deliveries). Among neonates, we had 6 cases of preterm labor. All neonates had negative PCR results. Conclusion: Clinical manifestations and paraclinical results were similar to nonpregnant patients. There was no evidence of vertical transmission. PLP and premature rupture of membranes (PROM) were the most common complications in the second and third trimesters of pregnant COVID-19 women, which can lead to rupture of the uterus. Termination and delivery should be planned individually. Key words: Pregnancy, COVID-19, Maternal-fetal infection transmission, Vertical transmission of infectious disease, Papulosquamous skin diseases

Cytotoxic effects of hydroalcoholic extract of Cuscuta chinensis on PC3 and MCF7 cancer cell lines

Objective: Chemoprevention of cancer by application of natural phytochemical compounds has been used to prevent, delay or suppress cancer progression. Cuscuta chinensis a traditional Iranian medicinal herb, has biological properties including anticancer, anti-aging, immuno-stimulatory and antioxidant effects. In this study, anti-proliferative effects of hydroalcoholic extract of C. chinensis on prostate (PC3) and breast (MCF7) cancer cell lines were investigated. Materials and Methods: In the current study, we investigated treatment of PC3 cells with different concentrations of C. chinensis (0, 100, 200, 300, 400, and 500 µg/ml) for 24 and 48 hr; also, MCF7 cells were treated with various concentrations (0-600 µg/ml) of C. chinensis for 48 and 72 hr and cell viability was assessed by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay. mRNA expression of BCL2 Associated X (Bax), B-cell lymphoma 2 (Bcl2), Cysteine-aspartic proteases (Caspase3) and Phosphatase and tensin homolog (PTEN) were analyzed by quantitative real-time PCR. Annexin V/PI staining and lactate dehydrogenase (LDH) cytotoxicity assay were used to detect apoptosis. Results: C. chinensis decreased PC3 and MCF7 cells viability in a dose- and time-dependent manner (p BAX/Bcl2 ratio, Caspase3 and PTEN increased in C. chinensis-treated cells compared to the control group. C. chinensis induced apoptosis (p <0.001) and LDH activity (p Conclusion: Our findings suggest that C. chinensis extract is able to inhibit proliferation and induce apoptosis in PC3 and MCF7 cell lines. Therefore, C. chinensis extract exerts antitumor activity against cancer cells

Medication Errors and its Contributing Factors among Midwives

Introduction: Medication errors are among the most serious health errors threatening patient safety in all countries, with major impacts on public health. Midwives as members of healthcare systems are prone to such errors. Therefore, in this study, we aimed to determine medication errors and the contributing factors among midwives working in maternity units of Mashhad University of Medical Sciences, Mashhad, Iran in 2015. Methods: This descriptive, cross-sectional study was performed on 104 employed midwives at four hospitals (Imam Reza, Ghaem, Omolbanin, and Hashemi Nezhad hospitals), affiliated to Mashhad University of Medical Sciences. The validity and reliability of the data collection tools were confirmed through content validity and internal consistency (Cronbach's alpha), respectively. For data analysis, descriptive and analytical tests, multiple linear regression, and negative binomial regression analysis were performed, using SPSS version 20 and STATA version 11. Results: The average incidence of medication errors for each midwife was 21.24±2.89 in the past six months. Among reasons against reporting medication errors, fear of confrontation with authorities (3.79±1.5) and attributing the medication error to individual factors by officials (3.88±1.34) had the highest average scores. The most common causes of medication errors were overcrowding of the ward (4.32±1.01), excessive workload and overexertion (4.19±1.08), and presence of critically ill patients in the ward (4.03±1.18). Conclusion: Overcrowding of the ward, fear of authorities, and attributing the medication error to individual factors were the main reasons against reporting medication errors, respectively. Therefore, more attention should be paid to error reporting systems, and workshops in this area are highly recommended