Wearable technologies and stigma in diabetes: the role of medical aesthetics

Fashion and design can help challenge diabetes stigma. Conor Farrington reports

Anti-CTLA-4 (CD 152) monoclonal antibody-induced autoimmune interstitial nephritis

Targeted immune-modulating agents are entering clinical practice in many specialties, providing novel therapeutic possibilities but introducing new potential toxicities. We present the first reported case, to our knowledge, of immune-mediated nephritis following the administration of Tremelimumab (CP-675, 206), an anti-cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) monoclonal antibody. High-dose steroid therapy led to a rapid improvement in renal function, avoiding the need for renal replacement therapy.Peer reviewe

Self-controlled case series with multiple event types

Self-controlled case series methods for events that may be classified as one of several types are described. When the event is non-recurrent, the different types correspond to competing risks. It is shown that, under circumstances that are likely to arise in practical applications, the SCCS multi-type likelihood reduces to the product of the type-specific likelihoods. For recurrent events, this applies whether or not the marginal type-specific counts are dependent. As for the standard SCCS method, a rare disease assumption is required for non-recurrent events. Several forms of this assumption are investigated by simulation. The methods are applied to data on MMR vaccine and convulsions (febrile and non-febrile), and to data on thiazolidinediones and fractures (at different sites)

Measurement of the differential cross-section of B + meson production in pp collisions at √s=7 TeV at ATLAS

The production cross-section of B + mesons is measured as a function of transverse momentum p T and rapidity y in proton-proton collisions at centre-of-mass energy s√=7 TeV, using 2.4 fb−1 of data recorded with the ATLAS detector at the Large Hadron Collider. The differential production cross-sections, determined in the range 9 GeV < p T < 120 GeV and |y| < 2.25, are compared to next-to-leading-order theoretical predictions

Dynamics of isolated-photon plus jet production in pp collisions at √s=7 TeV with the ATLAS detector

The dynamics of isolated-photon plus jet production in pp collisions at a centre-of-mass energy of 7 TeV has been studied with the ATLAS detector at the LHC using an integrated luminosity of 37 pb−1. Measurements of isolated-photon plus jet bin-averaged cross sections are presented as functions of photon transverse energy, jet transverse momentum and jet rapidity. In addition, the bin-averaged cross sections as functions of the difference between the azimuthal angles of the photon and the jet, the photon–jet invariant mass and the scattering angle in the photon–jet centre-of-mass frame have been measured. Next-to-leading-order QCD calculations are compared to the measurements and provide a good description of the data, except for the case of the azimuthal opening angle

Measurement of jet shapes in top-quark pair events at √s =7 TeV using the ATLAS detector

A measurement of jet shapes in top-quark pair events using 1.8 fb−1 of √s=7 TeV pp collision data recorded by the ATLAS detector at the LHC is presented. Samples of top-quark pair events are selected in both the single-lepton and dilepton final states. The differential and integrated shapes of the jets initiated by bottom-quarks from the top-quark decays are compared with those of the jets originated by light-quarks from the hadronic W-boson decays W→qq¯′ in the single-lepton channel. The light-quark jets are found to have a narrower distribution of the momentum flow inside the jet area than b-quark jets

Measurement of the production cross section of jets in association with a Z boson in pp collisions at √s=7 TeV with the ATLAS detector

Measurements of the production of jets of particles in association with a Z boson in pp collisions at s√=7 TeV are presented, using data corresponding to an integrated luminosity of 4.6 fb−1 collected by the ATLAS experiment at the Large Hadron Collider. Inclusive and differential jet cross sections in Z events, with Z decaying into electron or muon pairs, are measured for jets with transverse momentum p T > 30 GeV and rapidity |y| < 4.4. The results are compared to next-to-leading-order perturbative QCD calculations, and to predictions from different Monte Carlo generators based on leading-order and next-to-leading-order matrix elements supplemented by parton showers

Separated Fringe Packet Observations with the CHARA Array III. The Very High Eccentricity Binary HR 7345

After an eleven year observing campaign, we present the combined visual{spectroscopic orbit of the formerly unremarkable bright star HR 7345 (HD 181655, HIP 94981, GJ 754.2). Using the Separated Fringe Packet (SFP) method with the CHARA Array, we were able to determine a difficult to complete orbital period of 331.609 +/- 0.004 days. The 11 month period causes the system to be hidden from interferometric view behind the Sun for 3 years at a time. Due to the high eccentricity orbit of about 90% of a year, after 2018 January the periastron phase will not be observable again until late 2021. Hindered by its extremely high eccentricity of 0.9322 +/- 0.0001, the double-lined spectroscopic phase of HR 7345 is observable for 15 days. Such a high eccentricity for HR 7345 places it among the most eccentric systems in catalogs of both visual and spectroscopic orbits. For this system we determine nearly identical component masses of 0.941 +/- 0.076 Msun and 0.926 +/- 0.075 Msun as well as an orbital parallax of 41.08 +/- 0.77 mas.Comment: 20 pages, 3 figures, 4 table

An expert opinion in speech and language therapy: The Queen Square Intensive Comprehensive Aphasia Programme

Less is more, right? Wrong: more is more. Here we make the case that the total dose of speech and language therapy (SLT) is a key factor in improving persons with aphasia’s (PWA) outcomes. The challenge is: how can we deliver high-dose therapy when resources are stretched? We review the recent evidence for dose and timing of SLT and then describe one solution to the problem of dose that we are trialing at Queen Square, an Intensive Comprehensive Aphasia Programme (ICAP)