Bioactive flavanones from Luma chequen

A bioassay-guided chemical study of a methanolic extract of fresh leaves of Luma chequen led to the isolation of lumaflavanones A (1), B (2) and C (3) whose structures are proposed on the basis of NMR spectroscopic data. The structure of lumaflavanone A was confirmed by X-ray analysis. Antifeedant (Spodoptera littoralis), brine shrimp (Artemia salina) and fungistatic (Botrytis cinerea) bioassays showed that while 3 was the most active in the first two assays the mixture of 1 and 2 was more effective as a fungistatic

Alterations of cardiovascular complexity during acute exposure to high altitude: A multiscale entropy approach

Stays at high altitude induce alterations in cardiovascular control and are a model of specific pathological cardiovascular derangements at sea level. However, high-altitude alterations of the complex cardiovascular dynamics remain an almost unexplored issue. Therefore, our aim is to describe the altered cardiovascular complexity at high altitude with a multiscale entropy (MSE) approach. We recorded the beat-by-beat series of systolic and diastolic blood pressure and heart rate in 20 participants for 15 min twice, at sea level and after arrival at 4554 m a.s.l. We estimated Sample Entropy and MSE at scales of up to 64 beats, deriving average MSE values over the scales corresponding to the high-frequency (MSEHF) and low-frequency (MSELF) bands of heart-rate variability. We found a significant loss of complexity at heart-rate and blood-pressure scales complementary to each other, with the decrease with high altitude being concentrated at Sample Entropy and at MSEHF for heart rate and at MSELF for blood pressure. These changes can be ascribed to the acutely increased chemoreflex sensitivity in hypoxia that causes sympathetic activation and hyperventilation. Considering high altitude as a model of pathological states like heart failure, our results suggest new ways for monitoring treatments and rehabilitation protocols

Improving HTc Josephson Junctions (HTc JJ) by annealing: the role of vacancy-interstitial annihilation

We have studied the annealing effect in transport properties of High temperature Josephson Junctions (HTc JJ) made by ion irradiation. Low temperature annealing (80 degrees Celsius) increases the JJ transition temperature (TJ) and the Ic.Rn product, where Ic is the critical current and Rn the normal resistance. We found that the spread in JJ characteristics can be lowered by sufficient long annealing times. Using random walk numerical simulations, we showed that the characteristic annealing time and the evolution of the spread in JJ characteristics can be explained by a vacancy-interstitial annihilation process rather than by an oxygen diffusion one.Comment: 7 pages and 3 figures submitted to Applied Physics Letter

Magnetic patterning of (Ga,Mn)As by hydrogen passivation

We present an original method to magnetically pattern thin layers of (Ga,Mn)As. It relies on local hydrogen passivation to significantly lower the hole density, and thereby locally suppress the carrier-mediated ferromagnetic phase. The sample surface is thus maintained continuous, and the minimal structure size is of about 200 nm. In micron-sized ferromagnetic dots fabricated by hydrogen passivation on perpendicularly magnetized layers, the switching fields can be maintained closer to the continuous film coercivity, compared to dots made by usual dry etch techniques

Identification and selection rules of the spin-wave eigen-modes in a normally magnetized nano-pillar

We report on a spectroscopic study of the spin-wave eigen-modes inside an individual normally magnetized two layers circular nano-pillar (Permalloy$|$Copper$|$Permalloy) by means of a Magnetic Resonance Force Microscope (MRFM). We demonstrate that the observed spin-wave spectrum critically depends on the method of excitation. While the spatially uniform radio-frequency (RF) magnetic field excites only the axially symmetric modes having azimuthal index $\ell=0$, the RF current flowing through the nano-pillar, creating a circular RF Oersted field, excites only the modes having azimuthal index $\ell=+1$. Breaking the axial symmetry of the nano-pillar, either by tilting the bias magnetic field or by making the pillar shape elliptical, mixes different $\ell$-index symmetries, which can be excited simultaneously by the RF current. Experimental spectra are compared to theoretical prediction using both analytical and numerical calculations. An analysis of the influence of the static and dynamic dipolar coupling between the nano-pillar magnetic layers on the mode spectrum is performed

Enhanced fluctuations of the tunneling density of states near bottoms of Landau bands measured by a local spectrometer

We have found that the local density of states fluctuations (LDOSF) in a disordered metal, detected using an impurity in the barrier as a spectrometer, undergo enhanced (with respect to SdH and dHvA effects) oscillations in strong magnetic fields, omega _c\tau > 1. We attribute this to the dominant role of the states near bottoms of Landau bands which give the major contribution to the LDOSF and are most strongly affected by disorder. We also demonstrate that in intermediate fields the LDOSF increase with B in accordance with the results obtained in the diffusion approximation.Comment: 4 pages, 4 figure

Coulomb blockade of tunnelling through compressible rings formed around an antidot: an explanation for h/2eh/2e Aharonov-Bohm oscillations

We consider single-electron tunnelling through antidot states using a Coulomb-blockade model, and give an explanation for h/2e Aharonov-Bohm oscillations, which are observed experimentally when the two spins of the lowest Landau level form bound states. We show that the edge channels may contain compressible regions, and using simple electrostatics, that the resonance through the outer spin states should occur twice per h/e period. An antidot may be a powerful tool for investigating quantum Hall edge states in general, and the interplay of spin and charging effects that occurs in quantum dots.Comment: 5 pages, 4 Postscript figure

Detection of Coulomb Charging around an Antidot in the Quantum Hall Regime

We have detected oscillations of the charge around a potential hill (antidot) in a two-dimensional electron gas as a function of a large magnetic field B. The field confines electrons around the antidot in closed orbits, the areas of which are quantised through the Aharonov-Bohm effect. Increasing B reduces each state's area, pushing electrons closer to the centre, until enough charge builds up for an electron to tunnel out. This is a new form of the Coulomb blockade seen in electrostatically confined dots. Addition and excitation spectra in DC bias confirm the Coulomb blockade of tunnelling.Comment: 4 pages, 4 Postscript figure

Acoustic Phonon-Assisted Resonant Tunneling via Single Impurities

We perform the investigations of the resonant tunneling via impurities embedded in the AlAs barrier of a single GaAs/AlGaAs heterostructure. In the $I(V)$ characteristics measured at 30mK, the contribution of individual donors is resolved and the fingerprints of phonon assistance in the tunneling process are seen. The latter is confirmed by detailed analysis of the tunneling rates and the modeling of the resonant tunneling contribution to the current. Moreover, fluctuations of the local structure of the DOS (LDOS) and Fermi edge singularities are observed.Comment: accepted in Phys. Rev.

Microwave excitations associated with a wavy angular dependence of the spin transfer torque : model and experiments

The spin transfer torque (STT) can lead to steady precession of magnetization without any external applied field in magnetic spin valve where the magnetic layer have very different spin diffusion length. This effect is associated with an unusual angular dependence of the STT, called "wavy" (WAD-STT), predicted in the frame of diffusive models of spin transfer. In this article, we present a complete experimental characterization of the magnetization dynamics in the presence of a WAD-STT. The results are compared to the prediction of the magnetization dynamics obtained by single domain magnetic simulations (macrospin approximation). The macrospin simulations well reproduced the main static and dynamical experimental features (phase diagram, R(I) curves, dependence of frequency with current and field) and suggest that the dynamical excitations observed experimentally are associated with a large angle out-of-plane precession mode. The present work validates the diffusive models of the spin transfer and underlines the role of the spin accumulation and the spin relaxation effects on the STT