Spectral performance of Square Kilometre Array Antennas - II. Calibration performance

We test the bandpass smoothness performance of two prototype Square Kilometre Array (SKA) SKA1-Low log-periodic dipole antennas, SKALA2 and SKALA3 ('SKA Log-periodic Antenna'), and the current dipole from the Murchison Widefield Array (MWA) precursor telescope. Throughout this paper, we refer to the output complex-valued voltage response of an antenna when connected to a low-noise amplifier, as the dipole bandpass. In Paper I, the bandpass spectral response of the log-periodic antenna being developed for the SKA1-Low was estimated using numerical electromagnetic simulations and analysed using low-order polynomial fittings, and it was compared with the HERA antenna against the delay spectrum metric. In this work, realistic simulations of the SKA1-Low instrument, including frequencydependent primary beam shapes and array configuration, are used with a weighted leastsquares polynomial estimator to assess the ability of a given prototype antenna to perform the SKA Epoch of Reionisation (EoR) statistical experiments. This work complements the ideal estimator tolerances computed for the proposed EoR science experiments in Trott & Wayth, with the realized performance of an optimal and standard estimation (calibration) procedure. With a sufficient sky calibration model at higher frequencies, all antennas have bandpasses that are sufficiently smooth to meet the tolerances described in Trott & Wayth to perform the EoR statistical experiments, and these are primarily limited by an adequate sky calibration model and the thermal noise level in the calibration data. At frequencies of the Cosmic Dawn, which is of principal interest to SKA as one of the first next-generation telescopes capable of accessing higher redshifts, the MWA dipole and SKALA3 antenna have adequate performance, while the SKALA2 design will impede the ability to explore this era

Simulations of primary beam effects on the cosmic bispectrum phase observed with the Hydrogen Epoch of Reionization Array

The 21~cm transition from neutral Hydrogen promises to be the best observational probe of the Epoch of Reionisation. The main difficulty in measuring the 21 cm signal is the presence of bright foregrounds that require very accurate interferometric calibration. Closure quantities may circumvent the calibration requirements but may be, however, affected by direction dependent effects, particularly antenna primary beam responses. This work investigates the impact of antenna primary beams affected by mutual coupling on the closure phase and its power spectrum. Our simulations show that primary beams affected by mutual coupling lead to a leakage of foreground power into the EoR window, which can be up to $\sim4$ orders magnitude higher than the case where no mutual coupling is considered. This leakage is, however, essentially confined at $k < 0.3$~$h$~Mpc$^{-1}$ for triads that include 29~m baselines. The leakage magnitude is more pronounced when bright foregrounds appear in the antenna sidelobes, as expected. Finally, we find that triads that include mutual coupling beams different from each other have power spectra similar to triads that include the same type of mutual coupling beam, indicating that beam-to-beam variation within triads (or visibility pairs) is not the major source of foreground leakage in the EoR window

Spectral performance of SKA log-periodic antennas I: Mitigating spectral artefacts in SKA1-LOW 21 cm cosmology experiments

This paper is the first in a series of papers describing the impact of antenna instrumental artefacts on the 21-cm cosmology experiments to be carried out by the low frequency instrument (SKA1-LOW) of the Square Kilometre Array telescope (SKA), i.e., the Cosmic Dawn (CD) and the Epoch of Reionization (EoR). The smoothness of the passband response of the current log-periodic antenna being developed for the SKA1-LOW is analyzed using numerical electromagnetic simulations. The amplitude variations over the frequency range are characterized using low-order polynomials defined locally, in order to study the impact of the passband smoothness in the instrument calibration and CD/EoR Science. A solution is offered to correct a fast ripple found at 60~MHz during a test campaign at the SKA site at the Murchison Radio-astronomy Observatory, Western Australia in September 2015 with a minor impact on the telescope's performance and design. A comparison with the Hydrogen Epoch of Reionization Array antenna is also shown demonstrating the potential use of the SKA1-LOW antenna for the Delay Spectrum technique to detect the EoR

Elements Related to Heterogeneity of Antibody-Dependent Cell Cytotoxicity in Patients Under Trastuzumab Therapy for Primary Operable Breast Cancer Overexpressing Her2

Preliminary results from a pilot trial on trastuzumab's mechanism of action against operable breast tumors overexpressing Her2 suggested a role for antibody-dependent cell cytotoxicity (ADCC). To examine factors affecting ADCC intensity and variability, we extended this study to the phenotypic and functional analysis of circulating mononuclear cells in 18 patients. ADCC was induced by trastuzumab therapy in 15 of 18 patients (83%). Inability to develop ADCC in three patients did not depend on inadequate levels of trastuzumab because further increase in its concentration in vitro was ineffective. Rather, susceptibility to develop ADCC was fairly predicted by test with trastuzumab before therapy and was correlated to the number of lymphocytes coexpressing CD16 and CD56. Phenotypic analysis at the end of ADCC evaluating down-regulation of CD16, and up-regulation of CD69 and CD107a, confirmed that natural killer (NK) cells and CD56+ T cells were involved in productive engagement of trastuzumab. Also, the killing efficiency of CD16+ lymphocytes was influenced by 158 V/F polymorphism of FcγRIII (CD16), whereas variations of CD247 on NK cells were consistent with trends between ADCC before and after therapy. Complete pathologic response was observed in one patient showing ADCC of outstanding intensity, whereas four cases of partial response showed intermediate ADCC; none of the three patients unable to mount ADCC had significant tumor regression. These data indicate that quantity and lytic efficiency of CD16+ lymphocytes are major factors for ADCC induction by trastuzumab, and confirm that breast cancer responses to short-term trastuzumab monotherapy may depend on involvement of the ADCC mechanism. [Cancer Res 2007;67(24):11991–9

The Impact of Beam Variations on Power Spectrum Estimation for 21 cm Cosmology II: Mitigation of Foreground Systematics for HERA

One key challenge in detecting 21 cm cosmological signal at z > 6 is to separate the cosmological signal from foreground emission. This can be studied in a power spectrum space where the foreground is confined to low delay modes whereas the cosmological signal can spread out to high delay modes. When there is a calibration error, however, chromaticity of gain errors propagates to the power spectrum estimate and contaminates the modes for cosmological detection. The Hydrogen Epoch of Reionization Array (HERA) employs a high-precision calibration scheme using redundancy in measurements. In this study, we focus on the gain errors induced by nonredundancies arising from feed offset relative to the HERA's 14 meter parabolic dish element, and investigate how to mitigate the chromatic gain errors using three different methods: restricting baseline lengths for calibration, smoothing the antenna gains, and applying a temporal filter prior to calibration. With 2 cm/2 degree perturbations for translation/tilting motions, a level achievable under normal HERA operating conditions, the combination of the baseline cut and temporal filtering indicates that the spurious gain feature due to nonredundancies is significantly reduced, and the power spectrum recovers the clean foreground-free region. We found that the mitigation technique works even for large feed motions but in order to keep a stable calibration process, the feed positions need to be constrained to 2 cm for translation motions and 2 degree for tilting offset relative to the dish's vertex.Comment: Accepted for publication in Ap

DAYENU: a simple filter of smooth foregrounds for intensity mapping power spectra

We introduce DPSS Approximate lazY filtEriNg of foregroUnds (DAYENU), a linear, spectral filter for H I intensity mapping that achieves the desirable foreground mitigation and error minimization properties of inverse co-variance weighting with minimal modelling of the underlying data. Beyond 21-cm power-spectrum estimation, our filter is suitable for any analysis where high dynamic-range removal of spectrally smooth foregrounds in irregularly (or regularly) sampled data is required, something required by many other intensity mapping techniques. Our filtering matrix is diagonalized by Discrete Prolate Spheroidal Sequences which are an optimal basis to model band-limited foregrounds in 21-cm intensity mapping experiments in the sense that they maximally concentrate power within a finite region of Fourier space. We show that DAYENU enables the access of large-scale line-of-sight modes that are inaccessible to tapered discrete Fourier transform estimators. Since these modes have the largest SNRs,DAYENU significantly increases the sensitivity of 21-cm analyses over tapered Fourier transforms. Slight modifications allow us to use DAYENU as a linear replacement for iterative delay CLEAN ing (DAYENUREST). We refer readers to the Code section at the end of this paper for links to examples and code

Hydrogen Epoch of Reionization Array (HERA)

The Hydrogen Epoch of Reionization Array (HERA) is a staged experiment to measure 21 cm emission from the primordial intergalactic medium (IGM) throughout cosmic reionization ($z=6-12$), and to explore earlier epochs of our Cosmic Dawn ($z\sim30$). During these epochs, early stars and black holes heated and ionized the IGM, introducing fluctuations in 21 cm emission. HERA is designed to characterize the evolution of the 21 cm power spectrum to constrain the timing and morphology of reionization, the properties of the first galaxies, the evolution of large-scale structure, and the early sources of heating. The full HERA instrument will be a 350-element interferometer in South Africa consisting of 14-m parabolic dishes observing from 50 to 250 MHz. Currently, 19 dishes have been deployed on site and the next 18 are under construction. HERA has been designated as an SKA Precursor instrument. In this paper, we summarize HERA's scientific context and provide forecasts for its key science results. After reviewing the current state of the art in foreground mitigation, we use the delay-spectrum technique to motivate high-level performance requirements for the HERA instrument. Next, we present the HERA instrument design, along with the subsystem specifications that ensure that HERA meets its performance requirements. Finally, we summarize the schedule and status of the project. We conclude by suggesting that, given the realities of foreground contamination, current-generation 21 cm instruments are approaching their sensitivity limits. HERA is designed to bring both the sensitivity and the precision to deliver its primary science on the basis of proven foreground filtering techniques, while developing new subtraction techniques to unlock new capabilities. The result will be a major step toward realizing the widely recognized scientific potential of 21 cm cosmology.Comment: 26 pages, 24 figures, 2 table

Measuring HERA's Primary Beam in Situ: Methodology and First Results

The central challenge in 21 cm cosmology is isolating the cosmological signal from bright foregrounds. Many separation techniques rely on the accurate knowledge of the sky and the instrumental response, including the antenna primary beam. For drift-scan telescopes, such as the Hydrogen Epoch of Reionization Array (HERA), that do not move, primary beam characterization is particularly challenging because standard beam-calibration routines do not apply (Cornwell et al.) and current techniques require accurate source catalogs at the telescope resolution. We present an extension of the method from Pober et al. where they use beam symmetries to create a network of overlapping source tracks that break the degeneracy between source flux density and beam response and allow their simultaneous estimation. We fit the beam response of our instrument using early HERA observations and find that our results agree well with electromagnetic simulations down to a -20 dB level in power relative to peak gain for sources with high signal-to-noise ratio. In addition, we construct a source catalog with 90 sources down to a flux density of 1.4 Jy at 151 MHz.The central challenge in 21 cm cosmology is isolating the cosmological signal from bright foregrounds. Many separation techniques rely on the accurate knowledge of the sky and the instrumental response, including the antenna primary beam. For drift-scan telescopes, such as the Hydrogen Epoch of Reionization Array (HERA), that do not move, primary beam characterization is particularly challenging because standard beam-calibration routines do not apply (Cornwell et al.) and current techniques require accurate source catalogs at the telescope resolution. We present an extension of the method from Pober et al. where they use beam symmetries to create a network of overlapping source tracks that break the degeneracy between source flux density and beam response and allow their simultaneous estimation. We fit the beam response of our instrument using early HERA observations and find that our results agree well with electromagnetic simulations down to a -20 dB level in power relative to peak gain for sources with high signal-to-noise ratio. In addition, we construct a source catalog with 90 sources down to a flux density of 1.4 Jy at 151 MHz