Low in‑hospital mortality rate in patients with COVID‑19 receiving thromboprophylaxis: data from the multicentre observational START‑COVID Register

Abstract COVID-19 infection causes respiratory pathology with severe interstitial pneumonia and extra-pulmonary complications; in particular, it may predispose to thromboembolic disease. The current guidelines recommend the use of thromboprophylaxis in patients with COVID-19, however, the optimal heparin dosage treatment is not well-established. We conducted a multicentre, Italian, retrospective, observational study on COVID-19 patients admitted to ordinary wards, to describe clinical characteristic of patients at admission, bleeding and thrombotic events occurring during hospital stay. The strategies used for thromboprophylaxis and its role on patient outcome were, also, described. 1091 patients hospitalized were included in the START-COVID-19 Register. During hospital stay, 769 (70.7%) patients were treated with antithrombotic drugs: low molecular weight heparin (the great majority enoxaparin), fondaparinux, or unfractioned heparin. These patients were more frequently affected by comorbidities, such as hypertension, atrial fibrillation, previous thromboembolism, neurological disease,and cancer with respect to patients who did not receive thromboprophylaxis. During hospital stay, 1.2% patients had a major bleeding event. All patients were treated with antithrombotic drugs; 5.4%, had venous thromboembolism [30.5% deep vein thrombosis (DVT), 66.1% pulmonary embolism (PE), and 3.4% patients had DVT + PE]. In our cohort the mortality rate was 18.3%. Heparin use was independently associated with survival in patients aged ≥ 59 years at multivariable analysis. We confirmed the high mortality rate of COVID-19 in hospitalized patients in ordinary wards. Treatment with antithrombotic drugs is significantly associated with a reduction of mortality rates especially in patients older than 59 years

Enjoying Art: The Experience of Beauty from Understanding Regularities

Art production and enjoyment is a universal human behavior, yet the reasons why it evolved remain elusive. Works of art can convey strong emotions, and various authors attempted to explain the enjoyment of such emotions from an evolutionary perspective. Other authors focused instead on emergent properties of works of art: patterns and coherence, symmetry and proportions, harmony and consonance. Here, I argue that all these emergent properties fall into the definition of regularity, as well as other features that have been overlooked and yet create beauty in all arts (including literature). More precisely, I define a regular composition as having its elements arranged according to a rule that is understandable ‘a priori.’ Furthermore, I propose two novel evolutionary insights into the enjoyment of complex regularities. First, the enjoyment may stem from the drive to gain information on the environment, which would result in a preference for those arrangements that can be understood ‘a priori’ but provide information on a variety of elements. Second, because regularity is mostly a product of life, the attraction to regular stimuli might have evolved to promote the detection of living beings. This would encourage the interaction with other organisms in accordance with Wilson’s ‘biophilia’ hypothesis

Enjoying art: an evolutionary perspective on the esthetic experience from emotion elicitors

The ubiquity of human art prompted evolutionary psychologists to explore its origins as a potential adaptation to the environment. Here we focus on emotionally charged art and posit that affective affordances embedded into some artworks play a pivotal role in explaining why these artworks are enjoyed from an evolutionary perspective. Such features, recurring in various art forms, are interpreted as cues to the emotional state of others, enabling art consumers to engage in empathetic experiences and vicarious emotions. We explore the adaptive value of deriving pleasure from vicarious emotions, while also addressing the seemingly counterintuitive enjoyment of artworks that evoke negative emotions. We discuss the appreciation of vicarious emotions irrespective of their valence and maintain this appreciation to hold adaptive significance for three key reasons. Firstly, it aids art consumers in refining their interpretational schemes of internal states, potentially enhancing emotional regulation skills. Secondly, it contributes to a deeper understanding of the emotions of others, thereby fostering emotional intelligence and empathy. Lastly, the enjoyment of affectively charged artworks reinforces social cohesion by harmonizing the emotions of group members. This perspective provides a comprehensive framework for understanding the evolutionary underpinnings of the human capacity for art appreciation and emotional engagement

A telehandler vehicle as mobile laboratory for hydraulic-hybrid powertrain technology development

The paper describes the design of a prototype vehicle used by Dana Holding Corporation as a mobile laboratory for the development of Spicer® PowerBoost® hydraulic-hybrid powertrain technology. A telehandler vehicle was selected due to its versatility. Starting from the high-level requirements, design choices from the powertrain layout to the control architecture are discussed. The hydraulic-hybrid powertrain system is described, and its performance is analyzed based on representative driving cycles

A telehandler vehicle as mobile laboratory for hydraulic-hybrid powertrain technology development

The paper describes the design of a prototype vehicle used by Dana Holding Corporation as a mobile laboratory for the development of Spicer® PowerBoost® hydraulic-hybrid powertrain technology. A telehandler vehicle was selected due to its versatility. Starting from the high-level requirements, design choices from the powertrain layout to the control architecture are discussed. The hydraulic-hybrid powertrain system is described, and its performance is analyzed based on representative driving cycles

Wolbachia in Aedes koreicus: Rare Detections and Possible Implications

The emerging distribution of new alien mosquito species was recently described in Europe. In addition to the invasion of Aedes albopictus, several studies have focused on monitoring and controlling other invasive Aedes species, as Aedes koreicus and Aedes japonicus. Considering the increasing development of insecticide resistance in Aedes mosquitoes, new control strategies, including the use of bacterial host symbionts, are proposed. However, little is known about the bacterial communities associated with these species, thus the identification of possible candidates for Symbiotic Control is currently limited. The characterization of the natural microbiota of field-collected Ae. koreicus mosquitoes from North-East Italy through PCR screening, identified native infections of Wolbachia in this species that is also largely colonized by Asaia bacteria. Since Asaia and Wolbachia are proposed as novel tools for Symbiotic Control, our study supports their use for innovative control strategies against new invasive species. Although the presence of Asaia was previously characterized in Ae. koreicus, our study characterized this Wolbachia strain, also inferring its phylogenetic position. The co-presence of Wolbachia and Asaia may provide additional information about microbial competition in mosquito, and to select suitable phenotypes for the suppression of pathogen transmission and for the manipulation of host reproduction in Ae. koreicus

Ability of a Set of Trunk Inertial Indexes of Gait to Identify Gait Instability and Recurrent Fallers in Parkinson’s Disease

The aims of this study were to assess the ability of 16 gait indices to identify gait instability and recurrent fallers in persons with Parkinson’s disease (pwPD), regardless of age and gait speed, and to investigate their correlation with clinical and kinematic variables. The trunk acceleration patterns were acquired during the gait of 55 pwPD and 55 age-and-speed matched healthy subjects using an inertial measurement unit. We calculated the harmonic ratios (HR), percent recurrence, and percent determinism (RQAdet), coefficient of variation, normalized jerk score, and the largest Lyapunov exponent for each participant. A value of ≤1.50 for the HR in the antero-posterior direction discriminated between pwPD at Hoehn and Yahr (HY) stage 3 and healthy subjects with a 67% probability, between pwPD at HY 3 and pwPD at lower HY stages with a 73% probability, and it characterized recurrent fallers with a 77% probability. Additionally, HR in the antero-posterior direction was correlated with pelvic obliquity and rotation. RQAdet in the antero-posterior direction discriminated between pwPD and healthy subjects with 67% probability, regardless of the HY stage, and was correlated with stride duration and cadence. Therefore, HR and RQAdet in the antero-posterior direction can both be used as age- and-speed-independent markers of gait instability

Restoring biodiversity in the Mediterranean coralligenous-the MERCES project.

4th World Conference on Marine Biodiversity (WCMB 2018), 13-16 May 2018, MontrealThe temperate coralligenous bioconcretions are mainly built by the accumulation of encrusting coralline algae growing at low irradiance levels. They harbour approximately 10% of marine Mediterranean species (about 1600 species), including long-lived algae and invertebrates. Enhanced by climate change, several pressures affect coralligenous assemblages, leading to increased frequency of mass mortalities and dramatic loss of habitat complexity and biodiversity. The EU-funded project MERCES is developing innovative methodologies to restore macroinvertebrate habitat-forming species from three key taxonomic groups: Cnidaria/Anthozoa, Porifera/Demospongiae and Bryozoa. Restoration protocols are based on fragments/transplants from donor organisms and recruitment-enhancing devices. Collaboration with volunteers (divers and diving operators) in several phases of field activities proved crucial both to minimize underwater working time and to increase the sense of stewardship in a major users’ segment. Additionally, the MERCES project explores how to enhance restoration success by identifying the mechanisms conferring resistance to thermal stress in gorgonians. This is pursued by coupling thermotolerance experiments with next generation sequencing tools and facilitation processes (by comparing the outcomes of mono-specific vs. multi-specific transplanted assemblages). Results will be included in the strategic planning of restoration efforts in the Mediterranean in the context of global changePeer Reviewe