Treatment dilemmas in a young man presenting with narcolepsy and psychotic symptoms.

Psychotic features can be present in both narcolepsy and psychosis, which can result in challenges in diagnosis and management. The prevalence of both conditions is low and the reports in young people are scarce. Our report illustrates the relevance of a thorough differential diagnosis as well as the need to explore treatment avenues based on the evidence available for both narcolepsy and psychosis symptoms to try and maximise the therapeutic impact

DNA Torsional Solitons in Presence of localized Inhomogeneities

In the present paper we investigate the influence of inhomogeneities in the dynamics and stability of DNA open states, modeled as propagating solitons in the spirit of a Generalized Yakushevish Model. It is a direct consecuence of our model that there exists a critical distance between the soliton's center of mass and the inhomogeneity at which the interaction between them can change the stability of the open state.Furtherly from this results was derived a renormalized potential funtion.Comment: RevTex, 13 pages, 3 figures, final versio

Airy functions over local fields

Airy integrals are very classical but in recent years they have been generalized to higher dimensions and these generalizations have proved to be very useful in studying the topology of the moduli spaces of curves. We study a natural generalization of these integrals when the ground field is a non-archimedean local field such as the field of p-adic numbers. We prove that the p-adic Airy integrals are locally constant functions of moderate growth and present evidence that the Airy integrals associated to compact p-adic Lie groups also have these properties.Comment: Minor change

Optical Spectroscopy of X-Mega targets in the Carina Nebula - VI. FO 15: a new O-Type double-lined eclipsing binary

We report the discovery of a new O-type double-lined spectroscopic binary with a short orbital period of 1.4 days. We find the primary component of this binary, FO 15, to have an approximate spectral type O5.5Vz, i.e. a Zero-Age-Main-Sequence star. The secondary appears to be of spectral type O9.5V. We have performed a numerical model fit to the public ASAS photometry, which shows that FO 15 is also an eclipsing binary. We find an orbital inclination of ~ 80 deg. From a simultaneous light-curve and radial velocity solution we find the masses and radii of the two components to be 30 +/- 1 and 16 +/- 1 solar masses and 7.5 +/- 0.5 and 5.3 +/- 0.5 solar radii. These radii, and hence also the luminosities, are smaller than those of normal O-type stars, but similar to recently born ZAMS O-type stars. The absolute magnitudes derived from our analysis locate FO 15 at the same distance as Eta Carinae. From Chandra and XMM X-ray images we also find that there are two close X-ray sources, one coincident with FO 15 and another one without optical counterpart. This latter seems to be a highly variable source, presumably due to a pre-main-sequence stellar neighbour of FO 15.Comment: 11 pages, 9 figures, 3 tables. Accepted for publication in MNRAS. Higher resolution version available at http://lilen.fcaglp.unlp.edu.ar/papers2006.htm

Caveolin-1 is a risk factor for postsurgery metastasis in preclinical melanoma models

Melanomas are highly lethal skin tumours that are frequently treated by surgical resection. However, the efficacy of such procedures is often limited by tumour recurrence and metastasis. Caveolin-1 (CAV1) has been attributed roles as a tumour suppressor, although in late-stage tumours, its presence is associated with enhanced metastasis. The expression of this protein in human melanoma development and particularly how the presence of CAV1 affects metastasis after surgery has not been defined. CAV1 expression in human melanocytes and melanomas increases with disease progression and is highest in metastatic melanomas. The effect of increased CAV1 expression can then be evaluated using B16F10 murine melanoma cells injected into syngenic immunocompetent C57BL/6 mice or human A375 melanoma cells injected into immunodeficient B6Rag1−/− mice. Augmented CAV1 expression suppresses tumour formation upon a subcutaneous injection, but enhances lung metastasis of cells injected into the tail vein in both models. A procedure was initially developed using B16F10 melanoma cells in C57BL/6 mice to mimic better the situation in patients undergoing surgery. Subcutaneous tumours of a defined size were removed surgically and local tumour recurrence and lung metastasis were evaluated after another 14 days. In this postsurgery setting, CAV1 presence in B16F10 melanomas favoured metastasis to the lung, although tumour suppression at the initial site was still evident. Similar results were obtained when evaluating A375 cells in B6Rag1−/− mice. These results implicate CAV1 expression in melanomas as a marker of poor prognosis for patients undergoing surgery as CAV1 expression promotes experimental lung metastasis in two different preclinical models

The kinetics of oxygen and SO2 consumption by red wines. What do they tell about oxidation mechanisms and about changes in wine composition?

This work seeks to understand the kinetics of O2 and SO2 consumption of air-saturated red wine as a function of its chemical composition, and to describe the chemical changes suffered during the process in relation to the kinetics. Oxygen Consumption Rates (OCRs) are faster with higher copper and epigallocatechin contents and with higher absorbance at 620 nm and slower with higher levels of gallic acid and catechin terminal units in tannins. Acetaldehyde Reactive Polyphenols (ARPs) may be key elements determining OCRs. It is confirmed that SO2 is poorly consumed in the first saturation. Phenylalanine, methionine and maybe, cysteine, seem to be consumed instead. A low SO2 consumption is favoured by low levels of SO2, by a low availability of free SO2 caused by a high anthocyanin/tannin ratio, and by a polyphenolic profile poor in epigallocatechin and rich in catechin-rich tannins. Wines consuming SO2 efficiently consume more epigallocatechin, prodelphinidins and procyanidins