Perdas de solo e água por erosão: dez anos de pesquisa.

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Os efeitos-colaterais psiquiátricos do rimonabanto

OBJECTIVE: Experimental evidence has suggested that drugs that enhance cannabinoid type-1 (CB1) receptor activity may induce anxiolytic and antidepressant effects, whilst the opposite has been reported with antagonists. Thus, the objective of the present review is to discuss the potential psychiatric side-effects of CB1 receptor antagonists, such as rimonabant, which has been recently marketed in several countries for the treatment of smoking cessation, obesity and associated metabolic disorders. METHOD: Literature searches were performed in PubMed and SciELO databases up to February 2009. The terms searched were "obesity", "rimonabant", "cannabinoids", "unwanted effects", "diabetes", "smoking cessation" and "side-effects". RESULTS: Clinical trials have revealed that rimonabant may promote weight loss in obese patients, although it may also induce symptoms of anxiety and depression. DISCUSSION: Patients taking CB1 receptor antagonists should be carefully investigated for psychiatric side-effects. These drugs should not be prescribed for those already suffering from mental disorders. Nevertheless, the development of new compounds targeting the endocannabinoid system for the treatment of several conditions would be necessary and opportune.OBJETIVO: Evidência experimental sugere que drogas que aumentam a atividade dos receptores canabinóides tipo 1 (CB1) podem induzir efeitos ansiolíticos ou antidepressivos, enquanto que o oposto tem sido relatado com antagonistas. Assim, o objetivo da presente revisão é discutir os potenciais efeitos-colaterais psiquiátricos de antagonistas do receptor CB1, como o rimonabanto, que foi recentemente liberado para comercialização em diversos países para o tratamento do tabagismo, obesidade e de desordens metabólicas associadas. MÉTODO: Foi realizada uma busca na literatura no PubMed e Scielo até fevereiro de 2009, com os termos "obesity", "rimonabant", "cannabinoids", "unwanted effects", "diabetes" , "smoking cessation" e "side effects". RESULTADOS: Ensaios clínicos revelaram que o rimonabanto pode produzir perda de peso em pacientes obesos, embora também possa induzir sintomas de ansiedade e depressão. DISCUSSÃO: Pacientes tomando antagonistas do receptor CB1 devem ser cuidadosamente examinados quanto aos efeitos-colaterais psiquiátricos. Estas drogas não devem ser prescritas a indivíduos que já sofrem de transtornos mentais. Entretanto, o desenvolvimento de novos compostos que atuem no sistema endocanabinóide para o tratamento das mais diversas condições parece necessário e oportuno

Performance of Steers in \u3ci\u3eBrachiaria decumbens\u3c/i\u3e Pastures, Permanent and in Rotation with Soybean

The integration agriculture/pasture is an alternative that allows countless benefits to the rural producer. At Embrapa Agricultural West four production systems were studied and two of them involved animal production. The systems Soybean/Pasture Rotation and Permanent Pasture were compared from september/98 to may/99. The availability and residue of dry matter of green leaves blades (DMGLB), stems (SDM) and senescent material, the gain/animal and gain/area was evaluated. The availability was monthly assessed. Herbage residue was higher in the Soybean/Pasture Rotation system. This system allowed gain/animal and gain/ha of 0.814 kg/day and 582 kg/ha, respectively, whereas the Permanent Pasture system the gain was 0.749kg/day and 515 kg/ha

Estimativa do custo de produção de algodão, safra 2004/05, para Mato Grosso do Sul e Mato Grosso.

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Pastoreio de aveia e compactação do solo.

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Increased sensitivity to cocaine-induced analgesia in Spontaneously Hypertensive Rats (SHR)

This study examined the analgesic effect of cocaine in Spontaneously Hypertensive Rats (SHR), which are considered a suitable model for the study of attention deficit hyperactivity disorder (ADHD), and in Wistar (WIS) rats of both sexes using the hot-plate test. In addition, we tested whether habituation to the unheated hot-plate apparatus, that "normalizes" the basal hypoalgesic phenotype of SHR, alters the subsequent cocaine-induced analgesia (CIA) in this strain. SHR of both sexes were hypoalgesic compared to WIS rats in the hot-plate test and showed higher sensitivity to CIA. Habituation to the unheated hot-plate reduced the basal nociceptive latency of SHR, suggesting cognitive/emotional modulation of pain in this strain, but did not alter the magnitude of CIA. The present study shows increased sensitivity to CIA in SHR, which may be related to abnormalities in the mesocorticolimbic dopaminergic system. Further studies using SHR strain may reveal new information on the neurobiological mechanisms underlying ADHD and its co-morbidity with drug addiction

Predicting Sentence-Level Factuality of News and Bias of Media Outlets

Predicting the factuality of news reporting and bias of media outlets is surely relevant for automated news credibility and fact-checking. While prior work has focused on the veracity of news, we propose a fine-grained reliability analysis of the entire media. Specifically, we study the prediction of sentence-level factuality of news reporting and bias of media outlets, which may explain more accurately the overall reliability of the entire source. We first manually produced a large sentence-level dataset, titled "FactNews", composed of 6,191 sentences expertly annotated according to factuality and media bias definitions from AllSides. As a result, baseline models for sentence-level factuality prediction were presented by fine-tuning BERT. Finally, due to the severity of fake news and political polarization in Brazil, both dataset and baseline were proposed for Portuguese. However, our approach may be applied to any other language

Kalman Filtering in the Air Quality Monitoring

Data assimilation is a process where an improved prediction is obtained from a weighted combination between experimental measurements and mathematical model data. In the present work this procedure is applied to pollutant atmospheric dispersion by using a Kalman filter (KF). This is interesting approach, because the KF gives an output in which the balance between the data from the diffusion model and the experimental data is done automaticaly, through the Kalman gain. In addition, the Kalman filter computes the propagation of the error

Alterações em atributos físicos do solo decorrentes da rotação soja-pastagem, no sistema plantio direto.

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