CMB Lensing Reconstruction in Real Space

We explore the reconstruction of the gravitational lensing field of the cosmic microwave background in real space showing that very little statistical information is lost when estimators of short range on the celestial sphere are used in place of the customary estimators in harmonic space, which are nonlocal and in principle require a simultaneous analysis of the entire sky without any cuts or excisions. Because virtually all the information relevant to lensing reconstruction lies on angular scales close to the resolution scale of the sky map, the gravitational lensing dilatation and shear fields (which unlike the deflection field or lensing potential are directly related to the observations in a local manner) may be reconstructed by means of quadratic combinations involving only very closely separated pixels. Even though harmonic space provides a more natural context for understanding lensing reconstruction theoretically, the real space methods developed here have the virtue of being faster to implement and are likely to prove useful for analyzing realistic maps containing a galactic cut and possibly numerous small excisions to exclude point sources that cannot be reliably subtracted.Comment: 21 pages, 8 figure

A Follow-up to Implementing a Sizing Chart for Nasal Cannula Placement to Decrease Associated Pressure Ulcers in Infants

Background The Joint commission definition of a “Pressure Ulcer” is a broader term that includes decubitus ulcers, but also includes any ulcerations associated with pressure. In 2015, over a three-month period, the Intensive Care Nursery (ICN) at Thomas Jefferson University Hospital had five patients who developed pressure ulcers due to placement of an improper size nasal cannula being used for that patient. Infant nasal cannulas are typically classified as being for micro premature, premature, neonate, infant, and intermediate infant size patients. To this day, there is no instruction by most manufactures for fitting a nasal cannula to the actual size of the patient in kilograms. Also, cannulas are not of a universal size from various manufacturers.https://jdc.jefferson.edu/pulmcritcareposters/1006/thumbnail.jp

Anyons in discrete gauge theories with Chern-Simons terms

We study the effect of a Chern-Simons term in a theory with discrete gauge group H, which in (2+1)-dimensional space time describes (non-abelian) anyons. As in a previous paper, we emphasize the underlying algebraic structure, namely the Hopf algebra D(H). We argue on physical grounds that the addition of a Chern-Simons term in the action leads to a non-trivial 3-cocycle on D(H). Accordingly, the physically inequivalent models are labelled by the elements of the cohomology group H^3(H,U(1)). It depends periodically on the coefficient of the Chern-Simons term which model is realized. This establishes a relation with the discrete topological field theories of Dijkgraaf and Witten. Some representative examples are worked out explicitly.Comment: 18 page

SO(10) Cosmic Strings and SU(3) Color Cheshire Charge

Certain cosmic strings that occur in GUT models such as $SO(10)$ can carry a magnetic flux which acts nontrivially on objects carrying $SU(3)_{color}$ quantum numbers. We show that such strings are non-Abelian Alice strings carrying nonlocalizable colored ``Cheshire" charge. We examine claims made in the literature that $SO(10)$ strings can have a long-range, topological Aharonov-Bohm interaction that turns quarks into leptons, and observe that such a process is impossible. We also discuss flux-flux scattering using a multi-sheeted formalism.Comment: 37 Pages, 8 Figures (available upon request) phyzzx, iassns-hep-93-6, itp-sb-93-6

The initial conditions of the universe: how much isocurvature is allowed?

We investigate the constraints imposed by the current data on correlated mixtures of adiabatic and non-adiabatic primordial perturbations. We discover subtle flat directions in parameter space that tolerate large (~60%) contributions of non-adiabatic fluctuations. In particular, larger values of the baryon density and a spectral tilt are allowed. The cancellations in the degenerate directions are explored and the role of priors elucidated.Comment: 4 pages, 4 figures. Submitted to PR

VEGF188 promotes corneal reinnervation after injury

Vascular endothelial growth factor A (VEGF) induces angiogenesis and vascular hyperpermeability in ocular tissues and is therefore a key therapeutic target for eye conditions in which these processes are dysregulated. In contrast, the therapeutic potential of VEGF's neurotrophic roles in the eye has remained unexploited. In particular, it is not known whether modulating levels of any of the 3 major alternatively spliced VEGF isoforms might provide a therapeutic approach to promote neural health in the eye without inducing vascular pathology. Here, we have used a variety of mouse models to demonstrate differences in overall VEGF levels and VEGF isoform ratios across tissues in the healthy eye. We further show that VEGF isoform expression was differentially regulated in retinal versus corneal disease models. Among the 3 major isoforms - termed VEGF120, VEGF164, and VEGF188 - VEGF188 was upregulated to the greatest extent in injured cornea, where it was both necessary and sufficient for corneal nerve regeneration. Moreover, topical VEGF188 application further promoted corneal nerve regeneration without inducing pathological neovascularization. VEGF isoform modulation should therefore be explored further for its potential in promoting neural health in the eye