70 research outputs found
Experimental study of fragmentation products in the reactions 112Sn + 112Sn and 124Sn + 124Sn at 1 AGeV
Production cross-sections and longitudinal velocity distributions of the
projectile-like residues produced in the reactions 112Sn + 112Sn and 124Sn +
124Sn both at an incident beam energy of 1 AGeV were measured with the
high-resolution magnetic spectrometer, the Fragment Separator (FRS) of GSI. For
both reactions the characteristics of the velocity distributions and nuclide
production cross sections were determined for residues with atomic number Z
10. A comparison of the results of the two reactions is presented.Comment: 14 pages, 12 figure
In vitro evaluation of novel antimicrobial coatings for surgical sutures using octenidine
Background: Sutures colonized by bacteria represent a challenge in surgery due to their potential to cause surgical site infections. In order to reduce these type of infections antimicrobially coated surgical sutures are currently under development. In this study, we investigated the antimicrobial drug octenidine as a coating agent for surgical sutures. To achieve high antimicrobial efficacy and required biocompatibility for medical devices, we focused on optimizing octenidine coatings based on fatty acids. For this purpose, antimicrobial sutures were prepared with either octenidine-laurate or octenidine-palmitate at 11, 22, and 33 mu g/cm drug concentration normalized per length of sutures. Octenidine containing sutures were compared to the commercial triclosan-coated suture Vicryl (R) Plus. The release of octenidine into aqueous solution was analyzed and long-term antimicrobial efficacy was assessed via agar diffusion tests using Staphylococcus aureus. For determining biocompatibility, cytotoxicity assays (WST-1) were performed using L-929 mouse fibroblasts. Results: In a 7 days elution experiment, octenidine-palmitate coated sutures demonstrated much slower drug release (11 mu g/cm: 7 %;22 mu g/cm: 5 %;33 mu g/cm: 33 %) than octenidine-laurate sutures (11 mu g/cm: 82 %;22 mu g/cm: 88 %;33 mu g/cm: 87 %). Furthermore sutures at 11 mu g/cm drug content were associated with acceptable cytotoxicity according to ISO 10993-5 standard and showed, similar to Vicryl (R) Plus, relevant efficacy to inhibit surrounding bacterial growth for up to 9 days. Conclusions: Octenidine coated sutures with a concentration of 11 mu g/cm revealed high antimicrobial efficacy and biocompatibility. Due to their delayed release, palmitate carriers should be preferred. Such coatings are candidates for clinical testing in regard to their safety and efficacy
FlashCam: a fully-digital camera for the medium-sized telescopes of the Cherenkov Telescope Array
The FlashCam group is currently preparing photomultiplier-tube based cameras
proposed for the medium-sized telescopes (MST) of the Cherenkov Telescope Array
(CTA). The cameras are designed around the FlashCam readout concept which is
the first fully-digital readout system for Cherenkov cameras, based on
commercial FADCs and FPGAs as key components for the front-end electronics
modules and a high performance camera server as back-end. This contribution
describes the progress of the full-scale FlashCam camera prototype currently
under construction, as well as performance results also obtained with earlier
demonstrator setups. Plans towards the production and implementation of
FlashCams on site are also briefly presented.Comment: 8 pages, 6 figures. In Proceedings of the 34th International Cosmic
Ray Conference (ICRC2015), The Hague, The Netherlands. All CTA contributions
at arXiv:1508.0589
Performance Verification of the FlashCam Prototype Camera for the Cherenkov Telescope Array
The Cherenkov Telescope Array (CTA) is a future gamma-ray observatory that is
planned to significantly improve upon the sensitivity and precision of the
current generation of Cherenkov telescopes. The observatory will consist of
several dozens of telescopes with different sizes and equipped with different
types of cameras. Of these, the FlashCam camera system is the first to
implement a fully digital signal processing chain which allows for a traceable,
configurable trigger scheme and flexible signal reconstruction. As of autumn
2016, a prototype FlashCam camera for the medium-sized telescopes of CTA nears
completion. First results of the ongoing system tests demonstrate that the
signal chain and the readout system surpass CTA requirements. The stability of
the system is shown using long-term temperature cycling.Comment: 5 pages, 13 figures, Proceedings of the 9th International Workshop on
Ring Imaging Cherenkov Detectors (RICH 2016), Lake Bled, Sloveni
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