2,468 research outputs found
H2O and OH gas in the terrestrial planet-forming zones of protoplanetary disks
We present detections of numerous 10-20 micron H2O emission lines from two
protoplanetary disks around the T Tauri stars AS 205A and DR Tau, obtained
using the InfraRed Spectrograph on the Spitzer Space Telescope. Follow-up 3-5
micron Keck-NIRSPEC data confirm the presence of abundant water and spectrally
resolve the lines. We also detect the P4.5 (2.934 micron) and P9.5 (3.179
micron) doublets of OH and 12CO/13CO v=1-0 emission in both sources. Line
shapes and LTE models suggest that the emission from all three molecules
originates between ~0.5 and 5 AU, and so will provide a new window for
understanding the chemical environment during terrestrial planet formation. LTE
models also imply significant columns of H2O and OH in the inner disk
atmospheres, suggesting physical transport of volatile ices either vertically
or radially; while the significant radial extent of the emission stresses the
importance of a more complete understanding of non-thermal excitation
processes.Comment: 9 pages, 3 figures, 1 table, aastex, to appear in the Astrophysical
Journa
The c2d Spitzer spectroscopy survey of ices around low-mass young stellar objects, III: CH4
CH4 is proposed to be the starting point of a rich organic chemistry. Solid
CH4 abundances have previously been determined mostly toward high mass star
forming regions. Spitzer/IRS now provides a unique opportunity to probe solid
CH4 toward low mass star forming regions as well. Infrared spectra from the
Spitzer Space Telescope are presented to determine the solid CH4 abundance
toward a large sample of low mass young stellar objects. 25 out of 52 ice
sources in the (cores to disks) legacy have an absorption feature at 7.7
um, attributed to the bending mode of solid CH4. The solid CH4 / H2O abundances
are 2-8%, except for three sources with abundances as high as 11-13%. These
latter sources have relatively large uncertainties due to small total ice
column densities. Toward sources with H2O column densities above 2E18 cm-2, the
CH4 abundances (20 out of 25) are nearly constant at 4.7+/-1.6%. Correlation
plots with solid H2O, CH3OH, CO2 and CO column densities and abundances
relative to H2O reveal a closer relationship of solid CH4 with CO2 and H2O than
with solid CO and CH3OH. The inferred solid CH4 abundances are consistent with
models where CH4 is formed through sequential hydrogenation of C on grain
surfaces. Finally the equal or higher abundances toward low mass young stellar
objects compared with high mass objects and the correlation studies support
this formation pathway as well, but not the two competing theories: formation
from CH3OH and formation in gas phase with subsequent freeze-out.Comment: 27 pages, 7 figures, accepted by Ap
Modeling Spitzer observations of VV Ser. I. The circumstellar disk of a UX Orionis star
We present mid-infrared Spitzer-IRS spectra of the well-known UX Orionis star
VV Ser. We combine the Spitzer data with interferometric and spectroscopic data
from the literature covering UV to submillimeter wavelengths. The full set of
data are modeled by a two-dimensional axisymmetric Monte Carlo radiative
transfer code. The model is used to test the prediction of (Dullemond et al.
2003) that disks around UX Orionis stars must have a self-shadowed shape, and
that these disks are seen nearly edge-on, looking just over the edge of a
puffed-up inner rim, formed roughly at the dust sublimation radius. We find
that a single, relatively simple model is consistent with all the available
observational constraints spanning 4 orders of magnitude in wavelength and
spatial scales, providing strong support for this interpretation of UX Orionis
stars. The grains in the upper layers of the puffed-up inner rim must be small
(0.01-0.4 micron) to reproduce the colors (R_V ~ 3.6) of the extinction events,
while the shape and strength of the mid-infrared silicate emission features
indicate that grains in the outer disk (> 1-2 AU) are somewhat larger (0.3-3.0
micron). From the model fit, the location of the puffed-up inner rim is
estimated to be at a dust temperature of 1500 K or at 0.7-0.8 AU for small
grains. This is almost twice the rim radius estimated from near-infrared
interferometry. A best fitting model for the inner rim in which large grains in
the disk mid-plane reach to within 0.25 AU of the star, while small grains in
the disk surface create a puffed-up inner rim at ~0.7-0.8 AU, is able to
reproduce all the data, including the near-infrared visibilities. [Abstract
abridged]Comment: 12 pages, accepted for publication in Ap
Climatic Signals in Wood Property Variables of Picea Crassifolia
Little attention has been given to climatic signals in wood properties. In this study, ring width(RW), annual average microfibril angle (MFA), annual average tracheid radial diameter (TRD), andannual average density (DEN), as the annual and intra-annual wood property variables, were measured at high resolution by SilviScan-3 on dated Picea crassifolia trees. Dendroclimatological methods were used to analyze climatic signals registered in wood property variables. RW, MFA, and TRD negatively correlated with temperature and positively correlated with precipitation in the growing season, whereas the reverse was true for DEN. Climatic signals recorded in the earlywood were similar to those measured for the full width of the annual rings. Climatic signals recorded in latewood were very weak except for latewood MFA. This study showed that wood property variables could be extensive resources for learning more about the influences of climate on tree growth and how trees adapt to ongoing climate change
Problematic, absent and stigmatizing diagnoses in current mental disorders classifications: Results from the WHO-WPA and WHO-IUPsyS Global Surveys
This study examined English- and Spanish-speaking psychologists' and psychiatrists' opinions regarding problematic, absent and stigmatizing diagnoses in current mental disorders classifications (ICD-10 and DSM-IV), and their perceived need for a national classification of mental disorders. Answers to open-ended questions included in WHO-WPA and WHO-IUPsyS surveys were examined using an inductive content-analysis method. A total of 3,222 participants from 35 countries were included. The most problematic diagnostic group was personality disorders, especially among psychiatrists, because of poor validity and lack of specificity. Complex posttraumatic stress disorder was the most frequent diagnosis suggested for inclusion, mainly by psychologists, to better account for the distinct processes and consequences of complex trauma. Schizophrenia was the diagnosis most frequently identified as stigmatizing, particularly by psychiatrists, due to lack of public understanding or knowledge about the diagnosis. Of the 14.4% of participants who perceived a need for a national classification system, two-thirds were from Africa or Latin America. The rationales provided were that mental disorders classifications should consider cultural and socio-historical diversity in the expression of psychopathology, differences in the perception of what is and is not pathological in different nations, and the existence of culture-bound syndromes. Implications for ICD-11 development and dissemination are discussed. © 2014 Asociación Española de Psicología Conductual
A Spitzer c2d Legacy Survey to Identify and Characterize Disks with Inner Dust Holes
Understanding how disks dissipate is essential to studies of planet
formation. However, identifying exactly how dust and gas dissipates is
complicated due to difficulty in finding objects clearly in the transition of
losing their surrounding material. We use Spitzer IRS spectra to examine 35
photometrically-selected candidate cold disks (disks with large inner dust
holes). The infrared spectra are supplemented with optical spectra to determine
stellar and accretion properties and 1.3mm photometry to measure disk masses.
Based on detailed SED modeling, we identify 15 new cold disks. The remaining 20
objects have IRS spectra that are consistent with disks without holes, disks
that are observed close to edge-on, or stars with background emission. Based on
these results, we determine reliable criteria for identifying disks with inner
holes from Spitzer photometry and examine criteria already in the literature.
Applying these criteria to the c2d surveyed star-forming regions gives a
frequency of such objects of at least 4% and most likely of order 12% of the
YSO population identified by Spitzer.
We also examine the properties of these new cold disks in combination with
cold disks from the literature. Hole sizes in this sample are generally smaller
than for previously discovered disks and reflect a distribution in better
agreement with exoplanet orbit radii. We find correlations between hole size
and both disk and stellar masses. Silicate features, including crystalline
features, are present in the overwhelming majority of the sample although 10
micron feature strength above the continuum declines for holes with radii
larger than ~7 AU. In contrast, PAHs are only detected in 2 out of 15 sources.
Only a quarter of the cold disk sample shows no signs of accretion, making it
unlikely that photoevaporation is the dominant hole forming process in most
cases.Comment: 24 pages, 18 figures and 8 tables. Fixed a typo in Table
Protostellar holes: Spitzer Space Telescope observations of the protostellar binary IRAS16293-2422
Mid-infrared (23-35 micron) emission from the deeply embedded "Class 0"
protostar IRAS16293-2422 is detected with the Spitzer Space Telescope infrared
spectrograph. A detailed radiative transfer model reproducing the full spectral
energy distribution (SED) from 23 micron to 1.3 mm requires a large inner
cavity of radius 600 AU in the envelope to avoid quenching the emission from
the central sources. This is consistent with a previous suggestion based on
high angular resolution millimeter interferometric data. An alternative
interpretation using a 2D model of the envelope with an outflow cavity can
reproduce the SED but not the interferometer visibilities. The cavity size is
comparable to the centrifugal radius of the envelope and therefore appears to
be a natural consequence of the rotation of the protostellar core, which has
also caused the fragmentation leading to the central protostellar binary. With
a large cavity such as required by the data, the average temperature at a given
radius does not increase above 60-80 K and although hot spots with higher
temperatures may be present close to each protostar, these constitute a small
fraction of the material in the inner envelope. The proposed cavity will also
have consequences for the interpretation of molecular line data, especially of
complex species probing high temperatures in the inner regions of the envelope.Comment: Accepted for publication in ApJ Letter
Pilot proof of concept clinical trials of Stochastic Targeted (STAR) glycemic control
ABSTRACT: INTRODUCTION: Tight glycemic control (TGC) has shown benefits but has been difficult to achieve consistently. STAR (Stochastic TARgeted) is a flexible, model-based TGC approach directly accounting for intra- and inter- patient variability with a stochastically derived maximum 5% risk of blood glucose (BG) /=3 days. Written informed consent was obtained for all patients, and approval was granted by the NZ Upper South A Regional Ethics Committee. RESULTS: A total of 402 measurements were taken over 660 hours (~14/day), because nurses showed a preference for 2-hourly measurements. Median [interquartile range, (IQR)] cohort BG was 5.9 mmol/L [5.2-6.8]. Overall, 63.2%, 75.9%, and 89.8% of measurements were in the 4.0-6.5, 4.0-7.0, and 4.0-8.0 mmol/L bands. There were no hypoglycemic events (BG < 2.2 mmol/L), and the minimum BG was 3.5 mmol/L with 4.5% < 4.4 mmol/L. Per patient, the median [IQR] hours of TGC was 92 h [29-113] using 53 [19-62] measurements (median, ~13/day). Median [IQR] results: BG, 5.9 mmol/L [5.8-6.3]; carbohydrate nutrition, 6.8 g/h [5.5-8.7] (~70% goal feed median); insulin, 2.5 U/h [0.1-5.1]. All patients achieved BG < 6.1 mmol/L. These results match or exceed SPRINT and clinical workload is reduced more than 20%. CONCLUSIONS: STAR TGC modulating insulin and nutrition inputs provided very tight control with minimal variability by managing intra- and inter- patient variability. Performance and safety exceed that of SPRINT, which reduced mortality and cost in the Christchurch ICU. The use of glucometers did not appear to impact the quality of TGC. Finally, clinical workload was self-managed and reduced 20% compared with SPRINT
Latent Membrane Protein 1 as a molecular adjuvant for single-cycle lentiviral vaccines
Background Molecular adjuvants are a promising method to enhance virus-specific immune responses and protect against HIV-1 infection. Immune activation by ligands for receptors such as CD40 can induce dendritic cell activation and maturation. Here we explore the incorporation of two CD40 mimics, Epstein Barr Virus gene LMP1 or an LMP1-CD40 chimera, into a strain of SIV that was engineered to be limited to a single cycle of infection. Results Full length LMP1 or the chimeric protein LMP1-CD40 was cloned into the nef-locus of single-cycle SIV. Human and Macaque monocyte derived macrophages and DC were infected with these viruses. Infected cells were analyzed for activation surface markers by flow cytometry. Cells were also analyzed for secretion of pro-inflammatory cytokines IL-1β, IL-6, IL-8, IL-12p70 and TNF by cytometric bead array. Conclusions Overall, single-cycle SIV expressing LMP1 and LMP1-CD40 produced a broad and potent T1-biased immune response in human as well as rhesus macaque macrophages and DC when compared with control virus. Single-cycle SIV-LMP1 also enhanced antigen presentation by lentiviral vector vaccines, suggesting that LMP1-mediated immune activation may enhance lentiviral vector vaccines against HIV-1
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