538 research outputs found
Work book for the slow learning child
Thesis (Ed.M.)--Boston University, 1946. This item was digitized by the Internet Archive
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Improved quantification in small animal PET/MR
In translational medicine, complementary functional and morphological imaging techniques are used extensively to observe physiological processes in vivo and to assess structural changes as a result of disease progression. The combination of magnetic resonance imaging (MRI) and positron emission tomography (PET) provides excellent soft tissue contrast from MRI with exceptional sensitivity and specificity from PET. This thesis explores the use of sequentially acquired PET and MR images to
improve the quantification of small animal PET data.
The primary focus was to improve image-based estimates of the arterial input function (AIF), which defines the amount of PET tracer within blood plasma over time. The AIF is required to produce physiological parameters quantifying key processes such as metabolism or perfusion from dynamic PET images. The gold standard for AIF measurement, however, requires serial blood sampling over the course of a PET scan, which is invasive in rat studies but prohibitive in mice due to small total blood volumes.
To address this issue, the geometric transfer matrix (GTM) and recovery coefficient (RC) techniques were applied using anatomical MR images to enable the extraction of partial volume corrected image based AIFs from mouse PET images.
A non-invasive AIF extraction method was also developed for rats, beginning with the optimization of an automated voxel selection algorithm to assist in extracting MR contrast agent signal time courses from dynamic susceptibility contrast (DSC) MRI data. This procedure was then combined with dynamic contrast enhanced (DCE) MRI to track a combined injection of Gadolinium-based contrast agent and PET tracer through the rat brain. By comparison with gold standard tracer blood sample data, it was
found that normalized MRI-based AIFs could be successfully converted into PET tracer AIFs in the first pass phase when fitted with gamma variate functions.
Finally, a MR image segmentation method used to provide PET attenuation correction in mice was validated using the Cambridge split magnet PET/MR scannerâs transmission scanning capabilities. This work recommends that contributions from MR hardware in the PET field of view must be accounted forto gain accurate estimates of tracer uptake and standard uptake values (SUVs).
This thesis concludes that small animal MR data taken in the same imaging session can provide non-invasive methods to improve PET image quantification, giving added value to combined PET/MR studies over those conducted using PET alone.This PhD project was supported by a Medical Research Council (MRC) studentship, with grant code SRAG/038
A Time Lord, a Timeline and Legal Instruction
From online embeds to interactive displays, timelines can serve many purposes and tell powerful stories. In this session librarians team up with an archivist and a clinician to bring history to life, engage students, and preserve the scholarly and institutional milestones. A variety of tools for creating digital timelines and gathering content will be shared including TikiToki, TimeToast, and Piktochart. Comparisons will be given based on cost, technical limitations, collaborative potential, and general ease of use. Potential applications for timelines will also be shared in the form of examples including: a TimeToast embedded timeline tribute for individual faculty scholarship as a part of research guides a TikiToki multi-media timeline celebrating the growth of clinical and experiential learning programs over the course of 50 years a Piktochart timeline for classroom slides or printed display illustrating a series of significant trials
Time permitting, a live demo will guide attendees through the creation of a timeline with one of the tools. This session will be of interest to technologists, librarians and faculty alike. Attendees will walk away with an overview of the tools available for making timelines, ideas for how they could be used for instructional purposes, and a guide including examples and resources
Older peopleâs perspectives on living in integrated housing and care settings: the case of extra care housing
Purpose
This paper explores residentsâ perceptions and experiences of extra care housing as an integrated model of housing with care.
Design
Data were collected in a longitudinal qualitative study based in four extra care housing schemes. Interviews were held with residents, care workers, managers and local commissioners. Data were analysed thematically.
Findings
The study found that the integration of housing with care enabled many older people to manage their care proactively. However, the increasing number of residents with complex health and care needs led some residents to question the ability of the model to support residents to live independently when living with chronic illness.
Research limitations
The study struggled to recruit sufficient residents from the specialist dementia setting who were able to communicate their consent to take part in the research. In addition, the quality of qualitative data collected in interviews with participants at this setting reduced over successive rounds of interviews.
Implications
The study suggests the need to ensure residents are fully appraised of what levels of care and support are available when they decide to move into extra care housing schemes.
Originality
This paper provides a timely opportunity to consider extra care housing as an example of an integrated housing service, particularly in light of the current challenges facing the sector
The Ursinus Weekly, April 26, 1943
College thespians to give two plays as climax to May Day celebration ⢠Year book published by France forever for current year ⢠Crowning of May queen Nancy Landis to highlight Mother\u27s Day Saturday ⢠Rev. Tovey downs might rules right ⢠Musical portrays Easter scriptures ⢠Girls draw for rooms tonight and tomorrow ⢠Walter Sanborn to speak at annual Weekly banquet ⢠Volunteers donate blood ⢠Education 5-6 scheduled for September-October ⢠Dr. Appleton will address pre-med society Thursday ⢠Phys-edders to swim in Norristown Wednesday ⢠Dramatists elect officers ⢠Speaker to show slides at vespers Sunday night ⢠Men debaters reorganize; to hold banquet Thursday ⢠Girls\u27 varsities to open season with Penn and Temple teams ⢠Track meet will decide class champs and winners of intramural plaque ⢠Bayne is undefeated in college competition after four seasons ⢠Men begin baseball games ⢠Golfers to have tourney if enough players report ⢠Shreiner-Clamer takes close softball tilt from 612-Maples ⢠Girls to play off matches ⢠Miss Nat Hogeland guides students riding each week ⢠Keep courts in condition ⢠Student enjoys vacations thoroughly but needs rest after reaching Ursinus ⢠Students to visit library of pastor near Norristown ⢠German Club to entertain ⢠WSGA to install officershttps://digitalcommons.ursinus.edu/weekly/1762/thumbnail.jp
âGente de bienâ y falsos positivos: el costo humano de la indiferencia social
This article shows how extreme socioeconomic inequality and the criminalization of the poor constitute a threat to the guarantee of peace in Colombia. The study analyses the factors that lead to and sustained the boom in so called âfalse positivesâ in Colombia. These are conformed of a series of extrajudicial executions carried out against people in poor economic circumstances, particularly those belonging to marginalized sectors of society. The victims of the false positives were assassinated by members of the armed forces, in many cases in collaboration with illegal groups, and the murdered people were presented as members of illegal armed groups who were legally shot down in combat. These crimes were committed during the period between 2002 and 2008, and at least 3000 executions have been registered.
The practice of false positives constitutes one of the most atrocious crimes committed by a state in the 21st century, with flagrant attempts to achieve impunity for those responsible, while their victims are still fighting for justice and clarity. For this reason, this paper sustains that it is necessary to confront the extreme socioeconomic inequality and cultural imaginary that surround people effected by poverty in Colombia. Effectively, extreme inequality and its social representations have legitimised the dehumanisation of the countryâs most oppressed groups, and have contributed to the denial and even justify the crimes committed against them. This facilitates the conditions that allow these crimes to occur and be granted impunity. Until responsibility is taken for these aspects. The most vulnerable will continue to be victimised and the construction of peace will not transcend those who are part of the privileged elite.El presente artĂculo muestra cĂłmo las extremas desigualdades socioeconĂłmicas y la criminalizaciĂłn de la pobreza constituyen una amenaza para la garantĂa de la paz en Colombia. El estudio analiza los factores que condujeron y sustentaron el auge de los llamados âfalsos positivosâ en Colombia1. Lo anterior, conformado por una serie de ejecuciones extrajudiciales perpetuadas hacia personas de escasos recursos econĂłmicos, especialmente a aquellos pertenecientes a sectores sociales marginales. Las vĂctimas de los falsos positivos fueron asesinadas por miembros de las fuerzas militares, en varios casos, en colaboraciĂłn con grupos al margen de la ley, donde las personas asesinadas eran presentadas como integrantes de grupos armados ilegales dados de baja legalmente en combate. Estos delitos fueron cometidos durante el periodo comprendido entre los aĂąos 2002 y 2008, con un registro de por lo menos 3000 ejecuciones
Exploring the educational experiences and aspirations of Looked After Children and Young People (LACYP) in Wales
Understanding the educational experiences and opinions, attainment, achievement and aspirations of looked after children in Wales
This report presents the findings of research that explored the educational experiences attainment and aspirations of looked after children and young people (LACYP) in Wales.
The findings of the report are drawn from interviews with LACYP and an analysis of available statistics and literature on the looked after children population
Mesoscale eddy dissipation by a âzooâ of submesoscale processes at a western boundary
Mesoscale eddies are ubiquitous dynamical features that tend to propagate westward and disappear along ocean western boundaries. Using a multiscale observational study, we assess the extent to which eddies dissipate via a direct cascade of energy at a western boundary. We analyze data from a shipâbased microstructure and velocity survey, and an 18âmonth mooring deployment, to document the dissipation of energy in anticyclonic and cyclonic eddies impinging on the topographic slope east of the Bahamas, in the North Atlantic Ocean. These observations reveal high levels of turbulence where the steep and rough topographic slope modified the intensified northward flow associated with, in particular, anticyclonic eddies. Elevated dissipation was observed both nearâbottom and at mid depths (200â800 m). Nearâbottom turbulence occurred in the lee of a protruding escarpment, where elevated Froude numbers suggest hydraulic control. Energy was also radiated in the form of upwardâpropagating internal waves. Elevated dissipation at mid depths occurred in regions of strong vertical shear, where the topographic slope modified the vertical structure of the northward eddy flow. Here, low Richardson numbers and a local change in the isopycnal gradient of potential vorticity (PV) suggest that the elevated dissipation was associated with horizontal shear instability. Elevated midâdepth dissipation was also induced by topographic steering of the flow. This led to large anticyclonic vorticity and negative PV adjacent to the topographic slope, suggesting that centrifugal instability underpinned the local enhancement in dissipation. Our results provide a mechanistic benchmark for the realistic representation of eddy dissipation in ocean models
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