Origin of gamma-ray emission in the shell of Cassiopeia A

Non-thermal X-ray emission from the shell of Cassiopeia A (Cas A) has been an interesting subject of study, as it provides information about relativistic electrons and their acceleration mechanisms in the shocks. Chandra X-ray observatory revealed the detailed spectral and spatial structure of this SNR in X-rays. The spectral analysis of Chandra X-ray data of Cas A shows unequal flux levels for different regions of the shell, which can be attributed to different magnetic fields in those regions. Additionally, the GeV gamma-ray emission observed by Large Area Telescope on board Fermi Gamma Ray Space Telescope showed that the hadronic processes are dominating in Cas A, a clear signature of acceleration of protons. In this paper we aim to explain the GeV-TeV gamma-ray data in the context of both leptonic and hadronic scenario. We modeled the multi-wavelength spectrum of Cas A. We use synchrotron emission process to explain the observed non-thermal X-ray fluxes from different regions of the shell. These result in estimation of the model parameters, which are then used to explain TeV gamma-ray emission spectrum. We also use hadronic scenario to explain both GeV and TeV fluxes simultaneously. We show that a leptonic model alone cannot explain the GeV-TeV data. Therefore, we need to invoke a hadronic model to explain the observed GeV-TeV fluxes. We found that although pure hadronic model is able to explain the GeV-TeV data, a lepto-hadronic model provides the best fit to the data.Comment: Accepted in A&

Interchanging Functionality Among Homologous Elongation Factors Using Signatures of Heterotachy

Numerous models of molecular evolution have been formulated to describe the forces that shape sequence divergence among homologous proteins. These models have greatly enhanced our understanding of evolutionary processes. Rarely are such models empirically tested in the laboratory, and even more rare, are such models exploited to generate novel molecules useful for synthetic biology. Here, we experimentally demonstrate that the heterotachy model of evolution captures signatures of functional divergence among homologous elongation factors (EFs) between bacterial EF-Tu and eukaryotic eEF1A. These EFs are GTPases that participate in protein translation by presenting aminoacylated-tRNAs to the ribosome. Upon release from the ribosome, the EFs are recharged by nucleotide exchange factors EF-Ts in bacteria or eEF1B in eukaryotes. The two nucleotide exchange factors perform analogous functions despite not being homologous proteins. The heterotachy model was used to identify a set of sites in eEF1A/EF-Tu associated with eEF1B binding in eukaryotes and another reciprocal set associated with EF-Ts binding in bacteria. Introduction of bacterial EF-Tu residues at these sites into eEF1A protein efficiently disrupted binding of cognate eEF1B as well as endowed eEF1A with the novel ability to bind bacterial EF-Ts. We further demonstrate that eEF1A variants, unlike yeast wild-type, can function in a reconstituted in vitro bacterial translation system. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00239-013-9540-9) contains supplementary material, which is available to authorized users

Reliability Generalization Analysis of the Core Self-Evaluations Scale

As a multifaceted construct reflecting one’s self-esteem, generalized self-efficacy, locus of control, and emotional stability, core self-evaluations has become popular to measure in applied psychology research, especially given its conceptual importance and empirical usefulness for understanding the dispositional effects on employee attitudes and behaviors. Yet, less attention has been paid to the internal properties of its measurement, relative to its criterion-related validity evidence. Thus, we believe that it is useful and timely to report on meta-analytic evidence regarding the psychometric reliability and associated study characteristics of Core Self-Evaluations Scale (CSES; Judge et al., 2003) to inform their nature, use, and future development. Results demonstrated support for acceptable levels of coefficient alpha across measures (μα = .84, τ = .05). We discuss several implications for measuring CSE in a multidimensional and generalizable manner

Planetary migration in evolving planetesimals discs

In the current paper, we further improved the model for the migration of planets introduced in Del Popolo et al. (2001) and extended to time-dependent planetesimal accretion disks in Del Popolo and Eksi (2002). In the current study, the assumption of Del Popolo and Eksi (2002), that the surface density in planetesimals is proportional to that of gas, is released. In order to obtain the evolution of planetesimal density, we use a method developed in Stepinski and Valageas (1997) which is able to simultaneously follow the evolution of gas and solid particles for up to 10^7 yrs. Then, the disk model is coupled to migration model introduced in Del Popolo et al. (2001) in order to obtain the migration rate of the planet in the planetesimal. We find that the properties of solids known to exist in protoplanetary systems, together with reasonable density profiles for the disk, lead to a characteristic radius in the range 0.03-0.2 AU for the final semi-major axis of the giant planet.Comment: IJMP A in prin

Tc-Glutathione Complex (Tc -GSH) : Labelling, Chemical Characterization and Biodistribution in Rats

The chemical structure of 99mTc-GSH has been estabilished using the 99Tc isotope. Labeling of glutathione with technetium in the presence of stanous chloride gave a high yield result. In a comparative study between 99Tc and 99Tc glutathione, the Tc-GSH complex obtained was purified and characterized by uv, visible spectroscopy, HPLC, Biogel chromatography, mass and NMR spectroscopy. Stoichiometric analysis showed a 2 : 1 molar ratio of GSH/Tc for the reaction. The molecular mass assessed by mass spectroscopy was 727 Da corresponding to an oxo(bis) glutathione technetate. NMR studies demonstrated that each glutathione molecule was coordinated to technetium via cysteinyl sulfur and nitrogen atoms. The biodistribution of the complex was studied in normal rats. Blood clearance was rapid during the first hour involving a biexponential curve ( t1/2 (1) : 50 min, t1/2 (2) : 400 min ). No radioactive accumulation was found in any specific organ except kidney and bladder. All the activity excreted was found unchanged in urine. In conclusion, Tc-GSH displayed an anionic dimer form as GSH-Tc-GSH. We assume that the complex is a tetradentate (2N,2S) complex containing a pentavalent technetium coordinated by two thiol and nitrogen atoms of both GSH ligands, and an apical oxo group

Smart thinking on co-creation and engagement: Searchlight on underground built heritage

This paper aims to explore public participation for activating underground built heritage (UBH). It describes and analyses practices of stakeholders’ engagement in different UBH assets, based on experiences gathered in the scope of the European COST Action ‘Underground4value’. It brings together five inspiring cases from Italy, Portugal, Spain, Switzerland and the United Kingdom, in which digital and mobile technologies were used as tools to improve community experiences in UBH. Thus, the paper discusses ‘smartness’ from the perspective of people and communities around cultural assets, where ‘smartness’ becomes a new connotation and a pathway to advance (local) knowledge and know-how. Therefore, this paper takes on the challenge to define a smart city as an ecosystem for people’s empowerment and participation, and, in particular, to explore social tools for creating new values in heritage placemaking—where sharing knowledge becomes a fundamental principle.info:eu-repo/semantics/publishedVersio