Gender peculiarities of gastroesophageal reflux disease

We studied gender-specific clinical manifestations and risk factors for gastroesophageal reflux disease (GERD) in the urban population of Ulan-Ude. The study included 352 patients with GERD. It was found that in both sexes prevailed not erosive reflux disease. It was detected in 64,2% of men and in 88% of women (p = 0,005). Men significantly more often had severe forms of the disease: erosive esophagitis - 19,8% more often than in women (p = 0,04), in 2,9% of men we revealed esophageal ulcers, in 1,1% - Barrett esophagus, while the in women didn't have these forms of the disease. Daily repeated heartburn was found in women twice more often than in men. Average grade of GERD-Q questionnaire for women was also significantly higher than for men by 19% (p = 0,04). Women had higher levels of anxiety and depression (average grade on BDI was higher by 29% than in men). Men had significantly more frequently such risk factors as smoking, alcohol intake and women more often had diabetes, hypertension and coronary heart disease

Неотектоническое районирование трассы газопровода Починки – Грязовец МосковскоНижегородского региона

Based on the structural-geomorphological method, neotectonic zonation of the Pochinki-Gryazovets gas pipeline was carried out for the safety purposes. Taking into account the probable stress sources, the geodynamic conditions of block structures formation are considered. Studies made it possible to subdivide the pipeline area into two parts: southern and northern. The southern part of the gas pipeline is located within the block characterized by tensile stress conditions; the northern part of pipeline relates to the block affected by compressive stress. The boundary between these blocks is considered as a geodynamic active zone and poses the risk for the pipeline safety.На основе структурно-геоморфологического метода впервые проведено неотектоническое районирование газопроводной трассы Починки – Грязовец с целью безопасной эксплуатации. С учетом вероятных источников напряжений рассмотрены геодинамические условия формирования блоковых структур. Исследования позволили разделить протяженную трассу газопровода на две части: южную и северную. Южная часть трассы находится в пределах блока, подверженного влиянию напряжений растяжения, северная – в пределах блока, подверженного влиянию напряжений сжатия. Граница между этими блоками рассматривается в качестве геодинамически активной зоны и геоэкологически значимой для трубопроводной трассы

Relative efficiency of continuous and discrete methods of dynamical control of lasers

A direct comparison between continuous and discrete forms of control is investigated theoretically and numerically. Specifically we investigate energy-optimal control of switching of a periodically driven class B laser from stable to unstable pulsing regimes

Institutional analysis of the regulatory and legal framework for financial reporting control in Russia

The study contains the main approaches to the determination of various institutions affecting Russian accounting from the standpoint of their formal and informal types. In modern conditions, the economic actions of a subject must be matched to external factors that determine the correctness of economic decision-making, as well as consistency and the development of correct patterns and behavior algorithms that are most effective for each specific situation. Through the institutional analysis, the authors have identified several inconsistencies in the regulatory framework of related institutions and suggested ways to eliminate these disparities. Inter-institutional discrepancies have been found between law and accounting institutions, indicating non-compliance in the accounting practice of the substance over form principle, between recognition in the bookkeeping and tax accounting of the transfer of assets and liabilities ownership, as well as differences in the recording of investment real estate in the financial statements according to IFRS institutions and Russian national standards.peer-reviewe

On astrophysical solution to ultra high energy cosmic rays

We argue that an astrophysical solution to UHECR problem is viable. The pectral features of extragalactic protons interacting with CMB are calculated in model-independent way. Using the power-law generation spectrum $\propto E^{-\gamma_g}$ as the only assumption, we analyze four features of the proton spectrum: the GZK cutoff, dip, bump and the second dip. We found the dip, induced by electron-positron production on CMB, as the most robust feature, existing in energy range $1\times 10^{18} - 4\times 10^{19}$ eV. Its shape is stable relative to various phenomena included in calculations. The dip is well confirmed by observations of AGASA, HiRes, Fly's Eye and Yakutsk detectors. The best fit is reached at $\gamma_g =2.7$, with the allowed range 2.55 - 2.75. The dip is used for energy calibration of the detectors. After the energy calibration the fluxes and spectra of all three detectors agree perfectly, with discrepancy between AGASA and HiRes at $E> 1\times 10^{20}$ eV being not statistically significant. The agreement of the dip with observations should be considered as confirmation of UHE proton interaction with CMB. The dip has two flattenings. The high energy flattening at $E \approx 1\times 10^{19}$ eV automatically explains ankle. The low-energy flattening at $E \approx 1\times 10^{18}$ eV provides the transition to galactic cosmic rays. This transition is studied quantitatively. The UHECR sources, AGN and GRBs, are studied in a model-dependent way, and acceleration is discussed. Based on the agreement of the dip with existing data, we make the robust prediction for the spectrum at $1\times 10^{18} - 1\times 10^{20}$ eV to be measured in the nearest future by Auger detector.Comment: Revised version as published in Phys.Rev. D47 (2006) 043005 with a small additio

Протеогликаны в нормальной физиологии и канцерогенезе

Malignant transformation of any cell is associated with numerous physiological and morphological disorders at both genomic and protein levels, a variety of macromolecules being involved in. However, the tumour development and metastasis depends on not only the molecular characteristics of the tumour cell but also its interaction with the surrounding extracellular matrix (ECM), which is an important and necessary part of any tissue. An important role in this process belongs to the complex protein-carbohydrate molecules – proteoglycans (PG), which are one of the main component of ECM and cell surface of any tissue and are tightly involved in cell-cell and cell-matrix interactions and signaling. During carcinogenesis, significant changes in the PG structure and composition occur both at the surface of tumour cells and surrounding ECM, resulting in the transformation of normal ECM into a tumour microenvironment and deterioration of cell-cell and cell-matrix communication. Further, the tumorigenic niche contributes to active proliferation of the cancer cells, tumour development and metastasis. At present, many key PG are identified as possible diagnostic and prognostic molecular markers and target molecules for the creation of new antitumor drugs.The review describes the main PG types, their structure, localisation, functional role in normal cell and tissue physiology and participation in molecular mechanisms of carcinogenesis

Small Scale Anisotropy Predictions for the Auger Observatory

We study the small scale anisotropy signal expected at the Pierre Auger Observatory in the next 1, 5, 10, and 15 years of operation, from sources of ultra-high energy (UHE) protons. We numerically propagate UHE protons over cosmological distances using an injection spectrum and normalization that fits current data up to \sim 10^{20}\eV. We characterize possible sources of ultra-high energy cosmic rays (UHECRs) by their mean density in the local Universe, $\bar{\rho} = 10^{-r}$ Mpc$^{-3}$, with $r$ between 3 and 6. These densities span a wide range of extragalactic sites for UHECR sources, from common to rare galaxies or even clusters of galaxies. We simulate 100 realizations for each model and calculate the two point correlation function for events with energies above 4 \times 10^{19}\eV and above 10^{20}\eV, as specialized to the case of the Auger telescope. We find that for r\ga 4, Auger should be able to detect small scale anisotropies in the near future. Distinguishing between different source densities based on cosmic ray data alone will be more challenging than detecting a departure from isotropy and is likely to require larger statistics of events. Combining the angular distribution studies with the spectral shape around the GZK feature will also help distinguish between different source scenarios.Comment: 15 pages, 6 figures, 6 tables, submitted to JCA