7,956 research outputs found
The Use of a Laser Doppler Velocimeter in a Standard Flammability Tube
The use of the Laser Doppler Velocimeter, (LDV), to measure the flow associated with the passage of a flame through a standard flammability limit tube (SFLT) was studied. Four major results are presented: (1) it is shown that by using standard ray tracing calculations, the displacement of the LDV volume and the fringe rotation within the experimental error of measurement can be predicted; (2) the flow velocity vector field associated with passage of an upward propagating flame in an SFLT is determined; (3) it is determined that the use of a light interruption technique to track particles is not feasible; and (4) it is shown that a 25 mW laser is adequate for LDV measurements in the Shuttle or Spacelab
Teachers’ Perspectives on Year Two Implementation of a Kindergarten Readiness Assessment
In this study we examined teachers’ perspectives regarding the second year of implementing a Kindergarten Readiness Assessment (KRA). Using a mixed-methods approach, we focused on the administration process, the perceived benefits of the assessment, and how teachers used the assessment to inform instruction. We also investigated whether these differed by teacher and district characteristics and how KRA experiences were different in the second year of implementation. Research Findings: Teachers generally did not view the KRA as beneficial for instruction or for students, reporting administration difficulties, inadequate KRA content, and limited utility of KRA data for supporting instruction as ongoing barriers to KRA use. Although the administration process seemed to be easier in the second year, teachers still reported it as burdensome, cutting into important beginning of kindergarten activities. Notably, teacher training and experience were associated with perceptions. Practice or Policy: Reasons for perceived lack of utility have important implications for future KRA design and implementation. These include better integration of KRAs into existing assessment systems, recognizing the added burden of KRAs to teachers (particularly at the beginning of kindergarten), and the role that additional training may have in supporting use of KRAs at the local level
Celecoxib decreases prostaglandin E\u3csub\u3e2\u3c/sub\u3e concentrations in nipple aspirate fluid from high risk postmenopausal women and women with breast cancer
Background
Celecoxib inhibits PGE2 production in cancerous tissue. We previously reported that PGE2 levels in nipple aspirate fluid (NAF) and plasma were not decreased in women at increased breast cancer risk who received celecoxib 200 mg twice daily (bid). The endpoints of the current study were to determine if a short course of celecoxib 400 mg bid would decrease PGE2 levels in women 1) at increased breast cancer risk, and 2) with established breast cancer.
Methods
NAF and plasma samples were collected before, 2 weeks after taking celecoxib 400 mg bid, and two weeks after washout from 26 women who were at increased breast cancer risk. From 13 women with newly diagnosed breast cancer, NAF from the incident breast and plasma were collected before and on average 2 weeks after taking celecoxib. Additionally, in nine of the 13 women with breast cancer, NAF was collected from the contralateral breast.
Results
No consistent change in NAF or plasma PGE2 levels was noted in high risk premenopausal women. NAF PGE2 levels decreased after celecoxib administration in postmenopausal high risk women (p = 0.02), and in both the NAF (p = 0.02) and plasma (p = 0.03) of women with breast cancer.
Conclusion
Celecoxib 400 mg bid taken on average for 2 weeks significantly decreased NAF, but not plasma, PGE2 levels in postmenopausal high risk women, and decreased both NAF and plasma PGE2 levels in women with newly diagnosed breast cancer. PGE2 levels may predict celecoxib breast cancer prevention and treatment efficacy. Our observations are preliminary, and larger studies to confirm and extend these findings are warranted
Effective renormalized multi-body interactions of harmonically confined ultracold neutral bosons
We calculate the renormalized effective 2-, 3-, and 4-body interactions for N
neutral ultracold bosons in the ground state of an isotropic harmonic trap,
assuming 2-body interactions modeled with the combination of a zero-range and
energy-dependent pseudopotential. We work to third-order in the scattering
length a defined at zero collision energy, which is necessary to obtain both
the leading-order effective 4-body interaction and consistently include
finite-range corrections for realistic 2-body interactions. The leading-order,
effective 3- and 4-body interaction energies are U3 = -(0.85576...)(a/l)^2 +
2.7921(1)(a/l)^3 + O[(a/l)^4] and U4 = +(2.43317...)(a/l)^3 + O[(a\l)^4], where
w and l are the harmonic oscillator frequency and length, respectively, and
energies are in units of hbar*w. The one-standard deviation error 0.0001 for
the third-order coefficient in U3 is due to numerical uncertainty in estimating
a slowly converging sum; the other two coefficients are either analytically or
numerically exact. The effective 3- and 4-body interactions can play an
important role in the dynamics of tightly confined and strongly correlated
systems. We also performed numerical simulations for a finite-range boson-boson
potential, and it was comparison to the zero-range predictions which revealed
that finite-range effects must be taken into account for a realistic
third-order treatment. In particular, we show that the energy-dependent
pseudopotential accurately captures, through third order, the finite-range
physics, and in combination with the multi-body effective interactions gives
excellent agreement with the numerical simulations, validating our theoretical
analysis and predictions.Comment: Updated introduction, correction of a few typos and sign error
A dynamical and kinematical model of the Galactic stellar halo and possible implications for galaxy formation scenarios
We re-analyse the kinematics of the system of blue horizontal branch field
(BHBF) stars in the Galactic halo (in particular the outer halo), fitting the
kinematics with the model of radial and tangential velocity dispersions in the
halo as a function of galactocentric distance r proposed by Sommer-Larsen,
Flynn & Christensen (1994), using a much larger sample (almost 700) of BHBF
stars. The basic result is that the character of the stellar halo velocity
ellipsoid changes markedly from radial anisotropy at the sun to tangential
anisotropy in the outer parts of the Galactic halo (r greater than approx 20
kpc). Specifically, the radial component of the stellar halo's velocity
ellipsoid decreases fairly rapidly beyond the solar circle, from approx 140 +/-
10 km/s at the sun, to an asymptotic value of 89 +/- 19 km/s at large r. The
rapid decrease in the radial velocity dispersion is matched by an increase in
the tangential velocity dispersion, with increasing r.
Our results may indicate that the Galaxy formed hierarchically (partly or
fully) through merging of smaller subsystems - the 'bottom-up' galaxy formation
scenario, which for quite a while has been favoured by most theorists and
recently also has been given some observational credibility by HST observations
of a potential group of small galaxies, at high redshift, possibly in the
process of merging to a larger galaxy (Pascarelle et al 1996).Comment: Latex, 16 pages. 2 postscript figures. Submitted to the Astrophysical
Journal. also available at http://astro.utu.fi/~cflynn/outerhalo.htm
GIS data and tools available at SGS-LTER
The SGS-LTER research site was established in 1980 by researchers at Colorado State University as part of a network of long-term research sites within the US LTER Network, supported by the National Science Foundation. Scientists within the Natural Resource Ecology Lab, Department of Forest and Rangeland Stewardship, Department of Soil and Crop Sciences, and Biology Department at CSU, California State Fullerton, USDA Agricultural Research Service, University of Northern Colorado, and the University of Wyoming, among others, have contributed to our understanding of the structure and functions of the shortgrass steppe and other diverse ecosystems across the network while maintaining a common mission and sharing expertise, data and infrastructure.Poster presented at the 7th Shortgrass Steppe Symposium held in Fort Collins, Colorado on 1/14/05
Are the distributions of Fast Radio Burst properties consistent with a cosmological population?
High time resolution radio surveys over the last few years have discovered a
population of millisecond-duration transient bursts called Fast Radio Bursts
(FRBs), which remain of unknown origin. FRBs exhibit dispersion consistent with
propagation through a cold plasma and dispersion measures indicative of an
origin at cosmological distances. In this paper we perform Monte Carlo
simulations of a cosmological population of FRBs, based on assumptions
consistent with observations of their energy distribution, their spatial
density as a function of redshift and the properties of the interstellar and
intergalactic media. We examine whether the dispersion measures, fluences,
inferred redshifts, signal-to-noises and effective widths of known FRBs are
consistent with a cosmological population. Statistical analyses indicate that
at least 50 events at Parkes are required to distinguish between a constant
co-moving FRB density, and a FRB density that evolves with redshift like the
cosmological star formation rate density.Comment: 11 pages, 7 figures, 3 table
Brand Engagement and Consumer Innovativeness
Brand engagement describes the tendency of consumers to make the brands they buy part of their self-concept. This new insight into consumer behavior offers marketers many ways to create relationships with their customers. An unexplored aspect of brand engagement is how it is related to consumer innovativeness, the tendency to be among the first buyers of new products. The present study used survey data from 2399 adult U.S. consumers to show that brand engagement is positively related to consumer innovativeness. This finding suggests that in addition to promoting the features of new products likely to attract innovators, showing how the brand can express the selfconcept of the innovator may also encourage its adoption
Neutral, water-soluble poly(ester amide) hydrogels for cell encapsulation
© 2020 Elsevier Ltd Hydrogels are of significant interest for cell encapsulation and delivery in regenerative medicine. Poly(ester amide)s (PEAs) are a class of biodegradable polymers that exhibit promise for biomedical applications due to the degradability of the ester and amide linkages in their backbones, their preparation from biomolecules such as amino acids, and the ability to readily tune their properties through a modular synthesis approach. Water-soluble PEAs containing cationic arginine moieties have previously been developed, but to the best of our knowledge, neutral water-soluble PEAs based on non-charged amino acids have not been reported. Using a poly(ethylene glycol) (PEG)-based macromonomer, we describe here the syntheses of water-soluble amino acid-containing PEAs containing crosslinkable alkenes in their backbones. These PEAs were converted into hydrogels through photoinitiated crosslinking and their properties were compared, including gel content, water content, swelling, and Young\u27s moduli. Subsequent cell culture studies on a subset of hydrogels confirmed that human adipose-derived stromal cells (ASCs) showed \u3e 75% viability at 24 h post-encapsulation. To explore the potential of the hydrogels as cell delivery systems for applications in soft tissue regeneration, adipogenic differentiation of the encapsulated ASCs was probed in vitro at 7 days. Analysis of glycerol-3-phosphate dehydrogenase (GPDH) enzyme activity and intracellular lipid accumulation indicated that the hydrogels provided a supportive environment for ASC adipogenesis. Overall, these PEAs provide a new platform that warrants further development for regenerative medicine applications
- …