Draft Genome Sequences of Five Enterococcus Species Isolated from the Gut of Patients with Suspected Clostridium difficile Infection

Indexación: Scopus.We present draft genome sequences of five Enterococcus species from patients suspected of Clostridium difficile infection. Genome completeness was confirmed by presence of bacterial orthologs (97%). Gene searches using Hidden-Markov models revealed that the isolates harbor between seven and 11 genes involved in antibiotic resistance to tetracyclines, beta-lactams, and vancomycin.http://genomea.asm.org/content/5/20/e00379-17.ful

Methodology to calibrate the dissection properties of aorta layers from two sets of experimental measurements

Aortic dissection is a prevalent cardiovascular pathology that can have a fatal outcome. However, the mechanisms that trigger this disease and the mechanics of its progression are not fully understood. Computational models can help understand these issues, but they need a proper characterisation of the tissues. Therefore, we propose a methodology to obtain the dissection parameters of all layers in aortic tissue via the computational modelling of two different delamination tests: the peel and mixed tests. Both experimental tests have been performed in specimens of porcine aorta, where the intima-media and media-adventitia interfaces, as well as the medial layer, were dissected. These two tests have been modelled using a cohesive zone formulation for the separating interface and a hyperelastic anisotropic material model via an implicit static analysis. The dissection properties of each interface have been calibrated by reproducing the force-displacement curves obtained in the experimental tests. The values of peak and mean force of the experiments were fitted with an error below 10%. With this methodology, we intend to contribute to the development of reliable numerical tools for simulating aortic dissection and aortic aneurysm rupture. © 2021 by the authors. Licensee MDPI, Basel, Switzerland

The origin of the Acheulean: the 1.7 million-year-old site of FLK West, Olduvai Gorge (Tanzania)

The appearance of the Acheulean is one of the hallmarks of human evolution. It represents the emergence of a complex behavior, expressed in the recurrent manufacture of large-sized tools, with standardized forms, implying more advance forethought and planning by hominins than those required by the precedent Oldowan technology. The earliest known evidence of this technology dates back to c. 1.7 Ma. and is limited to two sites (Kokiselei [Kenya] and Konso [Ethiopia]), both of which lack fauna. The functionality of these earliest Acheulean assemblages remains unknown. Here we present the discovery of another early Acheulean site also dating to c. 1.7 Ma from Olduvai Gorge. This site provides evidence of the earliest steps in developing the Acheulean technology and is the oldest Acheulean site in which stone tools occur spatially and functionally associated with the exploitation of fauna. Simple and elaborate large-cutting tools (LCT) and handaxes co-exist at FLK West, showing that complex cognition was present from the earliest stages of the Acheulean. Here we provide a detailed technological study and evidence of the use of these tools on the butchery and consumption of fauna, probably by early Homo erectus sensu lato

Pulse quality analysis on soliton pulse compression and soliton self-frequency shift in a hollow-core photonic bandgap fiber

A numerical investigation of low-order soliton evolution in a proposed seven-cell hollow-core photonic bandgap fiber is reported. In the numerical simulation, we analyze the pulse quality evolution in soliton pulse compression and soliton self-frequency shift in three fiber structures with different cross-section sizes. In the simulation, we consider unchirped soliton pulses (of 400 fs) at the wavelength of 1060 nm. Our numerical results show that the seven-cell hollow-core photonic crystal fiber, with a cross-section size reduction of 2%, promotes the pulse quality on the soliton pulse compression and soliton self-frequency shift. For an input soliton pulse of order 3 (which corresponds to an energy of 1.69 μJ), the pulse gets compressed with a factor of up to 5.5 and a quality factor of 0.73, in a distance of 12 cm. It also experiences a soliton-self frequency shift of up to 28 nm, in a propagation length of 6 m, with a pulse shape quality of ≈ 0.80

Evaluación de riesgo de incendio urbano en el centro histórico de la ciudad de Guimarães

The main objective of this work was to evaluate the urban fire risk of the Historic Centre of Guimarães, Portugal, which was declared by UNESCO as a World Heritage Site in 2001. From the study of the singular urban, architectural and constructive characteristics of Historic Centre of Guimarães, the present research focused on the analysis of a broad set of information collected in situ and on its subsequent use to apply a simplified urban fire risk assessment methodology. A GIS tool (Geographic Information System) was used to process and plot the results, allowing to obtain vulnerability maps from which it is possible to assess the global vulnerability of the Historical Centre of Guimarães, as well as to identify the areas where, from the evaluation of four global factors related with the fire ignition, propagation, evacuation and combat, urban fire risk is potentially higher.El principal objetivo de este trabajo fue evaluar el riesgo de incendio urbano en el Centro Histórico de Guimaraes, Portugal, declarado Patrimonio Cultural de la Humanidad en 2001 por la UNESCO. A partir del estudio de las caráctertísticas urbanas, arquitectónicas y constructivas del Centro Histórico de Guimarães, la presente investigación se centró en el análisis de un amplio conjunto de información recogida in situ y en su posterior utilización para la aplicación de una metodología simplificada de evaluación de riesgo de incendio urbano. Los datos obtenidos fueron procesados con la herramienta GIS (Geographic Information System), preparándose planos donde se muestra el nivel de vulnerabilidad del Centro Histórico de Guimarães, además de detectar las zonas de mayor riesgo en función de los cuatro factores globales de riesgo asociado al inicio, propagación, evacuación y combate al incendio

Surgical-PEARL protocol:a multicentre prospective cohort study exploring aetiology, management and outcomes for patients with congenital anomalies potentially requiring surgical intervention

INTRODUCTION: Congenital anomalies affect over 2% of pregnancies. Surgical advances have reduced mortality and improved survival for patients with congenital anomalies potentially requiring surgical (CAPRS) intervention. However, our understanding of aetiology, diagnostic methods, optimal management, outcomes and prognostication is limited. Existing birth cohorts have low numbers of individual heterogenous CAPRS. The Surgical Paediatric congEnital Anomalies Registry with Long term follow-up (Surgical-PEARL) study aims to establish a multicentre prospective fetal, child and biological parent cohort of CAPRS. METHODS AND ANALYSIS: From 2022 to 2027, Surgical-PEARL aims to recruit 2500 patients with CAPRS alongside their biological mothers and fathers from up to 15 UK centres. Recruitment will be antenatal or postnatal dependent on diagnosis timing and presentation to a recruitment site. Routine clinical data including antenatal scans and records, neonatal intensive care unit (NICU) records, diagnostic and surgical data and hospital episode statistics will be collected. A detailed biobank of samples will include: parents’ blood and urine samples; amniotic fluid if available; children’s blood and urine samples on admission to NICU, perioperatively or if the child has care withdrawn or is transferred for extracorporeal membrane oxygenation; stool samples; and surplus surgical tissue. Parents will complete questionnaires including sociodemographic and health data. Follow-up outcome and questionnaire data will be collected for 5 years. Once established we will explore the potential of comparing findings in Surgical-PEARL to general population cohorts born in the same years and centres. ETHICS AND DISSEMINATION: Ethical and health research authority approvals have been granted (IRAS Project ID: 302251; REC reference number 22/SS/0004). Surgical-PEARL is adopted onto the National Institute for Health Research Clinical Research Network portfolio. Findings will be disseminated widely through peer-reviewed publication, conference presentations and through patient organisations and newsletters. TRIAL REGISTRATION NUMBER: ISRCTN12557586

Alternativas de búsqueda directa en Metalib y SFX

La presentación se llevó a cabo durante las 5as. Jornadas de Expania (Grupo de usuarios de ExLibris en España) celebradas en la Universitat Pompeu Fabra (Barcelona, 19-20/06/2008)La presentación describe las alternativas a SFX y Metalib, que la Biblioteca de la Universidad de Navarra, ofrece a sus usuarios para la búsqueda de sus recursos electrónicos. En concreto, un formulario Web, una barra de herramientas, utilizando LibX, y un Gadget para iGoogle

Intraspecific Variation in Pinus Pinaster PSII Photochemical Efficiency in Response to Winter Stress and Freezing Temperatures

As part of a program to select maritime pine (Pinus pinaster Ait.) genotypes for resistance to low winter temperatures, we examined variation in photosystem II activity by chlorophyll fluorescence. Populations and families within populations from contrasting climates were tested during two consecutive winters through two progeny trials, one located at a continental and xeric site and one at a mesic site with Atlantic influence. We also obtained the LT50, or the temperature that causes 50% damage, by controlled freezing and the subsequent analysis of chlorophyll fluorescence in needles and stems that were collected from populations at the continental trial site

Vegetation, climate and natural resources during Upper Pleistocene in Navalmaíllo Rockshelter (Calvero de la Higuera, Pinilla del Valle, Madrid)

Los datos polínicos, procedentes del Abrigo de Navalmaíllo (Pinilla del Valle,Madrid), constituyen un registro excepcional, al ser pioneros en cuanto a su resolución temporal para la zona de estudio. Las dataciones de la secuencia (71.685 ± 5.082 – 77.230 ± 6.016), aportan información paleoambiental para el Pleistoceno Superior, en un área, donde los yacimientos y depósitos naturales son formaciones relativamente recientes, con un registro generalmente a partir los últimos 3000-4000 años.Además, dado que en dicho abrigo se ha constatado, tanto desde el punto de vista paleontológico como arqueológico, una intensa ocupación humana, la composición y los cambios en el cortejo florístico, cobran un interés especial revelando las fluctuaciones climáticas, a través del tránsito desde paisajes boscosos, de índole mediterráneo, a espacios abiertos de carácter seco y fresco. Además el espectro polínico es capaz de explicar la falta del registro antracológico, y puede ser interpretado bajo la perspectiva de la potencialidad de los recursos que la cubierta vegetal ofreció a la comunidad humana, de neandertales, asentada en el territorioPollen data from the Navalmaíllo rockshelter (Pinilla del Valle, Madrid), constitute an exceptional record, being pioneers in terms of its temporal resolution for the study area. Dating of the sequence (71,685 ± 5,082 – 77,230 ± 6,016), provide information Upper Pleistocene period, in an area where the archaeological sites and natural deposits are relatively recent formations (around usually from 3000-4000 years ago). In addition, given that the coat you have shown, both from the paleontological and archaeological point of view, intense human occupation, the composition and changes in the floristic cortege, charge special interest revealing climatic fluctuations through the transit from forested landscapes of Mediterranean nature, open spaces of dry and fresh character.Also the pollen spectrum is able to explain the lack of the rich record, and it can be interpreted under the perspective of the potential of the resources offered by the vegetation cover to the human community, Neanderthals, settled in the territor

El yacimiento kárstico del Pleistoceno Superior de la Cueva del Camino en el Calvero de la Higuera (Pinilla del Valle, Madrid)

Depto. de Geodinámica, Estratigrafía y PaleontologíaFac. de Ciencias GeológicasTRUEpu