Pharmacovigilance : betamimetics drug exposure in pregnancy enhances cardiovascular disease risk of offspring

The circadian amplitude of neonatal blood pressure, monitored for 2 days at 30-minute intervals during the first week of life on 39 babies exposed in utero to betamimetics, was statistically significantly larger than that of the 126 unexposed babies. The respective circadian double amplitudes (± SEM) were 7.9 ± 0.8 vs. 5.6 ± 0.3 mm Hg for systolic blood pressure (P=0.005) and 5.7 ± 0.6 vs. 4.0 ± 0.2 mm Hg for diastolic blood pressure (P = 0.020). An above-threshold circadian amplitude of blood pressure being associated with an increased cardiovascular disease risk, the results, corroborated independently during adolescence, warrant caution in prescribing betamimetics to prevent premature labor

Duration of abpm as an important prerequisite for a reliable diagnosis of vascular variability disorders (VVDs)

ABPM records from 26 clinically healthy residents of Tosa City, Japan over 6 or 7 days were analyzed overall and day-by-day in order to determine the frequency of occurrence of vascular variability abnormalities (VVAs) and the extent of reproducibility of the results from one day to another. ABPM records over 18 to 33 hours from 360 patients of a specialized cardiology clinic in Almaty (Kazakhstan) with cardiovascular diseases of medium or high severity were also analyzed. Among all records from Tosa City, at least one VVA was found on at least one day in all residents. Twelve subjects with no overall abnormality had VVAs in 1 to 3 days. Of the remaining 14 subjects, only one had no overall abnormality but at least one VVA in 6 of 7 days. The other 13 had at least one VVA in 4 or more days as well as an overall abnormal record One or more VVAs occurred in 78% of the cardiac patients in Almaty. More than one type of VVA was found in 50% of the patients. In 22% of cardiac patients no VVA was found, despite the fact that these patients had cardiovascular diseases. The large day-to-day variability in circadian characteristics of blood pressure and heart rate observed in Tosa City and the associated presence or absence of VVA(s) on a given day indicate the need to monitor for longer than 24 hours and to repeat the monitoring once a VVA is detected, until historically feasible lifelong monitoring can be implemented

A chronopediatric pioneer who practices prehabilitation: a tribute to Theodor Hellbrugge on his 80th Birthday

Chronobiology in human childhood started in the early fifties and is closely connected with the name of Theo Hellbr\ufcgge. The topics of chronobiology covered a broad range. They included the circadian rhythm in many biological functions such as body temperature, blood pressure, frequency of the heart as well as of the respiration; furthermore and peak expiratory flow and the response of patients treated by corticosteroids and other drugs. This contribution notes the significance of this field for human development and underlines the main tasks for further scientific researches