Tick and Vector-borne Disease Expansion with Climate Change

We live in a rapidly changing world. Human activities, notably deforestation and burning of fossil fuels, have altered the composition of Earth’s atmosphere and contributed to the “greenhouse effect” to which the current global warming trend is attributed. Without a global effort to reduce greenhouse gas emissions, climate change will continue and accelerate over the coming decades. Average temperatures are rising, precipitation patterns are altered, and extreme weather events, including drought and floods, are expected to increase in frequency and intensity. The rationale for a link between climate change and vector-borne diseases is clear due to the sensitivity of arthropod life cycles to temperature and precipitation. However, the effects of climate change on vector-borne diseases of zoo and wild animals are also inextricably linked to other anthropogenic threats and drivers of disease emergence that cumulatively impact animal, human, and ecosystem health.</p

Markierungsversuche und Modellierung zur Bewertung der Gefährdung eines Trinkwasserbrunnens

Kurzfassung: In einem Porengrundwasserleiter aus Niederterrassenschottern bei Pratteln, Schweiz, wurde ein Markierungsversuch mit Uranin durchgeführt, um die Gefährdung eines Trinkwasserbrunnens durch ein 760 m talaufwärts gelegenen Ablagerungsstandort zu bewerten. Dabei wurde eine maximale Abstandsgeschwindigkeit von 127 m/d und ein Wiedererhalt von 0,93 % festgestellt. Der Tracer wurde auch in zwei intermediären Beobachtungsbrunnen nachgewiesen. Diese Studie diskutiert die Ursachen dieser hohen Fließgeschwindigkeit. Durch drei verschiedene analytische Modelle konnten die Durchgangskurven simuliert und Transportparameter bestimmt werden. Erst die Anwendung eines zweidimensionalen numerischen Modells (FEFLOW) mit vereinfachter Geometrie liefert aber eine hydrogeologisch konsistente, mögliche Erklärung aller Versuchsergebnisse. Demnach handelt es sich vermutlich um einen relativ homogenen Grundwasserleiter. Der steile Gradient (6 ‰) und die hohe Durchlässigkeit (3 · 10-2 m/s) verursachen die hohen Fließgeschwindigkeiten. Der Hauptteil der Tracerwolke strömt seitlich an den Brunnen vorbei. Durch später durchgeführte Kleinpumpversuche wurde diese Modellvorstellung weitgehend bestätigt. Diese Befunde sollten bei Schutz- und Sanierungskonzepten berücksichtigt werde

Bias-Dependent Generation and Quenching of Defects in Pentacene

We describe a defect in pentacene single crystals that is created by bias stress and persists at room temperature for an hour in the dark but only seconds with 420nm illumination. The defect gives rise to a hole trap at Ev + 0.38eV and causes metastable transport effects at room temperature. Creation and decay rates of the hole trap have a 0.67eV activation energy with a small (108 s-1) prefactor, suggesting that atomic motion plays a key role in the generation and quenching process.Comment: 10 pages, 3 figure

Realistic performance prediction in nanostructured solar cells as a function of nanostructure dimensionality and density

The behavior of quantum dot, quantum wire, and quantum well InAs/GaAs solar cells is studied with a very simplified model based on experimental results in order to assess their performance as a function of the low bandgap material volume fraction fLOW. The efficiency of structured devices is found to exceed the efficiency of a non-structured GaAs cell, in particular under concentration, when fLOW is high; this condition is easier to achieve with quantum wells. If three different quasi Fermi levels appear with quantum dots the efficiency can be much higher

Suppression of hole-hole scattering in GaAs/AlGaAs heterostructures under uniaxial compression

Resistance, magnetoresistance and their temperature dependencies have been investigated in the 2D hole gas at a [001] p-GaAs/Al$_{0.5}$Ga$_{0.5}$As heterointerface under [110] uniaxial compression. Analysis performed in the frame of hole-hole scattering between carriers in the two spin splitted subbands of the ground heavy hole state indicates, that h-h scattering is strongly suppressed by uniaxial compression. The decay time $\tau_{01}$ of the relative momentum reveals 4.5 times increase at a uniaxial compression of 1.3 kbar.Comment: 5 pages, 3 figures. submitted to Phys.Rev.

Preferential closed channel blockade of HERG potassium currents by chemically synthesised BeKm‐1 scorpion toxin

The scorpion toxin peptide BeKm‐1 was synthesised by fluorenylmethoxycarbonyl solid phase chemistry and folded by air oxidation. The peptide's effects on heterologous human ether‐a‐go‐go‐related gene potassium current (I HERG) in HEK293 cells were assessed using 'whole‐cell' patch clamp. Blockade of I HERG by BeKm‐1 was concentration‐dependent, temperature‐dependent, and rapid in onset and reversibility. Blockade also exhibited inverse voltage dependence, inverse dependence on duration of depolarisation, and reverse use‐ and frequency‐dependence. Blockade by BeKm‐1 and recombinant ergtoxin, another scorpion toxin known to block HERG, differed in their recovery from HERG current inactivation elicited by strong depolarisation and in their ability to block HERG when the channels were already activated. We conclude that synthetic BeKm‐1 toxin blocks HERG preferentially through a closed (resting) state channel blockade mechanism, although some open channel blockade also occurs

National Mesothelioma Virtual Bank: A standard based biospecimen and clinical data resource to enhance translational research

Background: Advances in translational research have led to the need for well characterized biospecimens for research. The National Mesothelioma Virtual Bank is an initiative which collects annotated datasets relevant to human mesothelioma to develop an enterprising biospecimen resource to fulfill researchers' need. Methods: The National Mesothelioma Virtual Bank architecture is based on three major components: (a) common data elements (based on College of American Pathologists protocol and National North American Association of Central Cancer Registries standards), (b) clinical and epidemiologic data annotation, and (c) data query tools. These tools work interoperably to standardize the entire process of annotation. The National Mesothelioma Virtual Bank tool is based upon the caTISSUE Clinical Annotation Engine, developed by the University of Pittsburgh in cooperation with the Cancer Biomedical Informatics Grid™ (caBIG™, see http://cabig.nci.nih.gov). This application provides a web-based system for annotating, importing and searching mesothelioma cases. The underlying information model is constructed utilizing Unified Modeling Language class diagrams, hierarchical relationships and Enterprise Architect software. Result: The database provides researchers real-time access to richly annotated specimens and integral information related to mesothelioma. The data disclosed is tightly regulated depending upon users' authorization and depending on the participating institute that is amenable to the local Institutional Review Board and regulation committee reviews. Conclusion: The National Mesothelioma Virtual Bank currently has over 600 annotated cases available for researchers that include paraffin embedded tissues, tissue microarrays, serum and genomic DNA. The National Mesothelioma Virtual Bank is a virtual biospecimen registry with robust translational biomedical informatics support to facilitate basic science, clinical, and translational research. Furthermore, it protects patient privacy by disclosing only de-identified datasets to assure that biospecimens can be made accessible to researchers. © 2008 Amin et al; licensee BioMed Central Ltd

Modelling Discharge Rates and Ground Settlement Induced by Tunnel Excavation

Interception of aquifers by tunnel excavation results in water inflow and leads to drawdown of the water table which may induce ground settlement. In this work, analytical and numerical models are presented which specifically address these groundwater related processes in tunnel excavation. These developed models are compared and their performance as predictive tools is evaluated. Firstly, the water inflow in deep tunnels is treated. It is shown that introducing a reduction factor accounting for the effect of effective stress on hydrodynamic parameters avoids overestimation. This effect can be considered in numerical models using effective stress-dependent parameters. Then, quantification of ground settlement is addressed by a transient analytical solution. These solutions are then successfully applied to the data obtained during the excavation of the La Praz exploratory tunnel in the Western Alps (France), validating their usefulness as predictive tools