22,020 research outputs found
Poisson splitting by factors
Given a homogeneous Poisson process on with intensity
, we prove that it is possible to partition the points into two sets,
as a deterministic function of the process, and in an isometry-equivariant way,
so that each set of points forms a homogeneous Poisson process, with any given
pair of intensities summing to . In particular, this answers a
question of Ball [Electron. Commun. Probab. 10 (2005) 60--69], who proved that
in , the Poisson points may be similarly partitioned (via a
translation-equivariant function) so that one set forms a Poisson process of
lower intensity, and asked whether the same is possible for all . We do not
know whether it is possible similarly to add points (again chosen as a
deterministic function of a Poisson process) to obtain a Poisson process of
higher intensity, but we prove that this is not possible under an additional
finitariness condition.Comment: Published in at http://dx.doi.org/10.1214/11-AOP651 the Annals of
Probability (http://www.imstat.org/aop/) by the Institute of Mathematical
Statistics (http://www.imstat.org
Long-term orbital lifetime predictions
Long-term orbital lifetime predictions are analyzed. Predictions were made for three satellites: the Solar Max Mission (SMM), the Long Duration Exposure Facility (LDEF), and the Pegasus Boiler Plate (BP). A technique is discussed for determining an appropriate ballistic coefficient to use in the lifetime prediction. The orbital decay rate should be monitored regularly. Ballistic coefficient updates should be done whenever there is a significant change in the actual decay rate or in the solar activity prediction
Core compressor exit stage study. 1: Aerodynamic and mechanical design
The effect of aspect ratio on the performance of core compressor exit stages was demonstrated using two three stage, highly loaded, core compressors. Aspect ratio was identified as having a strong influence on compressors endwall loss. Both compressors simulated the last three stages of an advanced eight stage core compressor and were designed with the same 0.915 hub/tip ratio, 4.30 kg/sec (9.47 1bm/sec) inlet corrected flow, and 167 m/sec (547 ft/sec) corrected mean wheel speed. The first compressor had an aspect ratio of 0.81 and an overall pressure ratio of 1.357 at a design adiabatic efficiency of 88.3% with an average diffusion factor or 0.529. The aspect ratio of the second compressor was 1.22 with an overall pressure ratio of 1.324 at a design adiabatic efficiency of 88.7% with an average diffusion factor of 0.491
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Pathogenesis of feline enteric coronavirus infection.
Fifty-one specific pathogen-free (SPF) cats 10 weeks to 13 years of age were infected with a cat-to-cat fecal-oral passed strain of feline enteric coronavirus (FECV). Clinical signs ranged from unapparent to a mild and self-limiting diarrhea. Twenty-nine of these cats were FECV naĆÆve before infection and followed sequentially for fecal virus shedding and antibody responses over a period of 8-48 months. Fecal shedding, as determined by real-time polymerase chain reaction (RT-PCR) from rectal swabs, appeared within a week and was significantly higher in kittens than older cats. FECV shedding remained at high levels for 2-10 months before eventually evolving into one of three excretion patterns. Eleven cats shed the virus persistently at varying levels over an observation period of 9-24 months. Eleven cats appeared to have periods of virus shedding interlaced with periods of non-shedding (intermittent or recurrent shedders), and seven cats ceased shedding after 5-19 months (average 12 months). There was no change in the patterns of virus shedding among cats that were excreting FECV at the time of a secondary challenge exposure. Four cats, which had ceased shedding, re-manifested a primary type infection when secondarily infected. Cats with higher feline coronavirus (FCoV) antibody titers were significantly more likely to shed virus, while cats with lower titers were significantly less likely to be shedding. Twenty-two kittens born to experimentally infected project queens began shedding virus spontaneously, but never before 9-10 weeks of age. Natural kittenhood infections appeared to be low grade and abortive. However, a characteristic primary type infection occurred following experimental infection with FECV at 12-15 weeks of age. Pregnancy, parturition and lactation had no influence on fecal shedding by queens. Methylprednisolone acetate treatment did not induce non-shedders to shed and shedders to increase shedding
High-Precision Entropy Values for Spanning Trees in Lattices
Shrock and Wu have given numerical values for the exponential growth rate of
the number of spanning trees in Euclidean lattices. We give a new technique for
numerical evaluation that gives much more precise values, together with
rigorous bounds on the accuracy. In particular, the new values resolve one of
their questions.Comment: 7 pages. Revision mentions alternative approach. Title changed
slightly. 2nd revision corrects first displayed equatio
Isolated sequences from the linked Myf-5 and MRF4 genes drive distinct patterns of muscle-specific expression in transgenic mice
In developing mouse embryos, MyoD family regulatory genes are expressed specifically in muscle precursors and mature myofibers. This pattern, taken together with the well-established ability of MyoD family members to convert a variety of cell types to skeletal muscle, suggests a significant role for these genes in regulating skeletal myogenesis. The possibility that expression of these genes may be causally associated with segregation of the myogenic lineage from other mesodermal derivatives, or with the subsequent maintenance of muscle phenotypes at later times, raises the issue of how MyoD family genes are themselves regulated during development. In this work, we have initiated studies to identify DNA sequences that govern Myf-5 and MRF4 (herculin, myf-6) transcription. Myf-5 is the first of the MyoD family to be expressed in the developing mouse embryo, while MRF4 is the most abundantly expressed myogenic factor in postnatal animals. In spite of their strikingly divergent patterns of expression, Myf-5 and MRF4 are tightly linked in the mouse genome; their translational start codons are only 8.5 kilobases apart. Here, the 5' flanking regions of the mouse Myf-5 and MRF4 genes were separately linked to a bacterial Ī²-galactosidase (lacZ) gene, and these constructs were each used to produce several lines of transgenic mice. Transgene expression was monitored by X-gal staining of whole embryos and by in situ hybridization of embryo sections. For the Myf-5/lacZ lines, the most intense transgene expression was in the visceral arches and their craniofacial muscle derivatives, beginning at day 8.75 post coitum (p.c.). This correlates with endogenous Myf-5 expression in visceral arches. However, while Myf-5 is also expressed in somites starting at day 8 p.c., transgene expression in the trunk is not observed until day 12 p.c. Thus, the Myf-5/lacZ construct responds to early Myf-5 activators in the visceral arches but not in the somites, suggesting that myogenic determination in the nonsomitic head mesoderm may be under separate control from that of the somitic trunk mesoderm. MRF4/lacZ lines displayed an entirely different pattern from Myf-5. Transgene expression appeared in muscles starting at day 16.5 p.c. and became increasingly prominent at later times. However, an early wave of myotomal expression that is characteristic of the endogenous MRF4 was not recapitulated by the transgene
Algebraic structure of stochastic expansions and efficient simulation
We investigate the algebraic structure underlying the stochastic Taylor
solution expansion for stochastic differential systems.Our motivation is to
construct efficient integrators. These are approximations that generate strong
numerical integration schemes that are more accurate than the corresponding
stochastic Taylor approximation, independent of the governing vector fields and
to all orders. The sinhlog integrator introduced by Malham & Wiese (2009) is
one example. Herein we: show that the natural context to study stochastic
integrators and their properties is the convolution shuffle algebra of
endomorphisms; establish a new whole class of efficient integrators; and then
prove that, within this class, the sinhlog integrator generates the optimal
efficient stochastic integrator at all orders.Comment: 19 page
Kinetics and Inhibition Studies of the L205R Mutant of cAMP-Dependent Protein Kinase Involved in Cushingās Syndrome
Overproduction of cortisol by the hypothalamusāpituitaryāadrenal hormone system results in the clinical disorder known as Cushing\u27s syndrome. Genomics studies have identified a key mutation (L205R) in the Ī±āisoform of the catalytic subunit of cAMPādependent protein kinase (PKACĪ±) in adrenal adenomas of patients with adrenocorticotropic hormoneāindependent Cushing\u27s syndrome. Here, we conducted kinetics and inhibition studies on the L205RāPKACĪ± mutant. We have found that the L205R mutation affects the kinetics of both Kemptide and ATP as substrates, decreasing the catalytic efficiency (kcat/KM) for each substrate by 12āfold and 4.5āfold, respectively. We have also determined the IC50 and Ki for the peptide substrateācompetitive inhibitor PKI(5ā24) and the ATPācompetitive inhibitor H89. The L205R mutation had no effect on the potency of H89, but causes a \u3e 250āfold loss in potency for PKI(5ā24). Collectively, these data provide insights for the development of L205RāPKACĪ± inhibitors as potential therapeutics
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