Gender and Innovation: State of the Art and a Research Agenda

Purpose - The purpose of the article is to present a framework for research on gender and innovation. The framework is developed based on a review of current literature in the area; it is applied to provide a context for the articles in this special issue and to offer suggestions for future research.&nbsp; Design/methodology/approach - The article relies on a literature review of gender and innovation. Additional literature searches on Scopus were conducted to provide an overview of the area. In addition, comparative analogies are sought from research fields of gender and entrepreneurship as well as gender and technology. Findings - The article presents the scope and issues in current research on gender and innovation. Based on our overview, research in this area is conducted in various disciplines applying a variety of methodological approaches. In order to make sense of the current research we developed a framework consisting of various approaches to, gender and innovation; these include gender as a variable, construction and process and innovation as a result, process and discourse. Research implications - Based on the review, several recommendations for future research are made. First, future research should question the connection between technology and innovation, and purposefully seek innovation activity also in low-tech and service sectors and firms. Innovation scholars and policy makers should not primarily target radical and product innovations but should be equally interested in incremental and process innovations. Second, understanding women&rsquo;s innovation activity needs to be embedded in understanding the normative frames and structural factors at play. A particular theoretical call is linked to the study of power and innovation. Third, it is imperative to develop and apply new methodological approaches and new operationalizations of innovation and innovators. Practical implications - By focusing on gender and innovation, it is possible to discover innovation as a gender biased phenomenon. Policy makers should bear this in mind when developing innovation policies. Originality/value - This introductory article puts forward a framework on gender and innovation that helps to make sense of the current state-of-the-art and to develop new research questions that need to be addressed for further theorising within the field.</p

Absolute Magnitude Calibration for Giants based on the Colour-Magnitude Diagrams of Galactic Clusters. II-Calibration with SDSS

We present an absolute magnitude calibration for red giants with the colour magnitude diagrams of six Galactic clusters with different metallicities i.e. M92, M13, M3, M71, NGC 6791 and NGC 2158. The combination of the absolute magnitudes of the red giant sequences with the corresponding metallicities provides calibration for absolute magnitude estimation for red giants for a given $(g-r)_{0}$ colour. The calibration is defined in the colour interval 0.45 $\leq(g-r)_{0}\leq$ 1.30 mag and it covers the metallicity interval $-2.15\leq \lbrack Fe/H \rbrack \leq$ +0.37 dex. The absolute magnitude residuals obtained by the application of the procedure to another set of Galactic clusters lie in the interval $-0.28< \Delta M \leq +0.43$ mag. However, the range of 94% of the residuals is shorter, $-0.1<\Delta M \leq+0.4$ mag. The mean and the standard deviation of (all) residuals are 0.169 and 0.140 mag, respectively. The derived relations are applicable to stars older than 2 Gyr, the age of the youngest calibrating cluster.Comment: 12 pages, including 5 figures and 10 tables, accepted for publication in PASA. arXiv admin note: substantial text overlap with arXiv:1204.429

Absolute Magnitude Calibration for Red Giants based on the Colour-Magnitude Diagrams of Galactic Clusters. III-Calibration with 2MASS

We present two absolute magnitude calibrations, $M_{J}$ and $M_{K_s}$, for red giants with the colour magnitude diagrams of five Galactic clusters with different metallicities i.e. M92, M13, M71, M67, and NGC 6791. The combination of the absolute magnitudes of the red giant sequences with the corresponding metallicities provides calibration for absolute magnitude estimation for red giants for a given colour. The calibrations for $M_{J}$ and $M_{K_s}$ are defined in the colour intervals $1.3\leq(V-J)_{0}\leq2.8$ and $1.75 \leq (V-K_{s})_{0}\leq 3.80$ mag, respectively, and they cover the metallicity interval $-2.15 \leq \lbrack Fe/H \rbrack \leq +0.37$ dex. The absolute magnitude residuals obtained by the application of the procedure to another set of Galactic clusters lie in the intervals $-0.08<\Delta M_{J}\leq +0.34$ and $-0.10< \Delta M_{K_s}\leq +0.27$ mag for $M_{J}$ and $M_{K_s}$, respectively. The means and standard deviations of the residuals are $= 0.137$ and $\sigma_{M_J}=0.080$, and $=0.109$ and $\sigma_{M_{K_{s}}}=0.123$ mag. The derived relations are applicable to stars older than 4 Gyr, the age of the youngest calibrating cluster.Comment: 20 pages, including 8 figures and 22 tables, accepted for publication in PASA. arXiv admin note: substantial text overlap with arXiv:1206.275

Optimal focusing for maximal collection of entangled narrow-band photon pairs into single-mode fibers

We present a theoretical and experimental investigation of the emission characteristics and the flux of photon pairs generated by spontaneous parametric downconversion in quasi-phase matched bulk crystals for the use in quantum communication sources. We show that, by careful design, one can attain well defined modes close to the fundamental mode of optical fibers and obtain high coupling efficiencies also for bulk crystals, these being more easily aligned than crystal waveguides. We distinguish between singles coupling, conditional coincidence, and pair coupling, and show how each of these parameters can be maximized by varying the focusing of the pump mode and the fiber-matched modes using standard optical elements. Specifically we analyze a periodically poled KTP-crystal pumped by a 532 nm laser creating photon pairs at 810 nm and 1550 nm. Numerical calculations lead to coupling efficiencies above 94% at optimal focusing, which is found by the geometrical relation L/z_R to be ~ 1 to 2 for the pump mode and ~ 2 to 3 for the fiber-modes, where L is the crystal length and z_R is the Rayleigh-range of the mode-profile. These results are independent on L. By showing that the single-mode bandwidth decreases as 1/L, we can therefore design the source to produce and couple narrow bandwidth photon pairs well into the fibers. Smaller bandwidth means both less chromatic dispersion for long propagation distances in fibers, and that telecom Bragg gratings can be utilized to compensate for broadened photon packets--a vital problem for time-multiplexed qubits. Longer crystals also yield an increase in fiber photon flux proportional to sqrt{L}, and so, assuming correct focusing, we can only see advantages using long crystals.Comment: 19 pages, 15 figures, ReVTeX4, minor revisio

Unintended weight loss in the elderly living at home: the aged in homecare project (Adhoc)

Objective: To describe associations between unintended weight loss (UWL) and characteristics of nutritional status. Design: A comparative cross-sectional assessment study at 11 sites in Europe. The target population was a stratified random sample of 4,455 recipients of home care (405 in each random sample from 11 urban areas) aged 65 years and older. Measurements: the Resident Assessment Instrument for Home Care, version 2.0. Epidemiological and medical characteristics of clients and service utilisation were recorded in a standardized, comparative manner. UWL was defined as information of 5% or more weight loss in the last 30 days (or 10% or more in the last 180 days). Results: The final sample consisted of 4,010 persons; 74% were female. The mean ages were 80.9 ± 7.5 years (males) and 82.8 ± 7.3 years (females). No associations were found between single diagnoses and UWL, except for cancer. Cancer patients were excluded from further analyses. Persons with a Cognitive Performance Scale value (CPS) > 3 (impaired) had increased risk of UWL (OR = 2.0) compared with those scoring < 3 (less impaired). Only in the oldest group did we find a significant association between UWL and reduction in ADL and IADL functions, comparing those who scored 3 or less with those who scored more than 3 (disabled). A binary logistic regression model explained 26% of UWL: less than one meal/day, reduced appetite, malnutrition, reduced social activity, experiencing a flare-up of a recurrent or chronic problem, and hospitalisation were important indicators. Conclusion: We recommend a regular comprehensive assessment in home care to identify clients with potential risk factors for weight loss and malnutrition, in particular those discharged from hospital, and those with physical dependency or cognitive problems. This study may provide incentives to create tailored preventive strategies

Home care needs of extremely obese elderly european women

Objective: To examine the health and needs of extremely obese women aged over 65 years receiving home care in Europe. Study design: A cross-sectional assessment study based on the Aged in Home Care (AdHOC) project recruited 2974 women aged 65 or over who were receiving home care at 11 sites in European countries. Extreme obesity was defined as ‘Obesity of such a degree as to interfere with normal activities, including respiration’. Main outcome measures: Resident Assessment Instrument for Home Care (RAI-HC version 2.0); Activity of Daily Living Scale; Instrumental Activity of Daily Living Scale; the Minimum Data Set Cognitive Performance Scale; and a health profile. Results: One hundred and twenty women (4.0%) were extremely obese. They were younger than their thinner counterparts, with a median age of 78.3 versus 83.3 years, and they more often had multiple health complaints and needed more help with mobility outside the home. The extremely obese had received home care longer than the non-extremely obese (median 28.7 versus 36.6 months). Extremely obese women also needed more help with personal care than the other group and, due to lower age, they were less cognitively impaired. Conclusions: Extreme obesity is a problem that increasingly affects home care of elderly women

Cytolytic granule polarization and degranulation controlled by different receptors in resting NK cells

The relative contribution to cytotoxicity of each of the multiple NK cell activation receptors has been difficult to assess. Using Drosophila insect cells, which express ligands of human NK cell receptors, we show that target cell lysis by resting NK cells is controlled by different receptor signals for cytolytic granule polarization and degranulation. Intercellular adhesion molecule (ICAM)-1 on insect cells was sufficient to induce polarization of granules, but not degranulation, in resting NK cells. Conversely, engagement of the Fc receptor CD16 by rabbit IgG on insect cells induced degranulation without specific polarization. Lysis by resting NK cells occurred when polarization and degranulation were induced by the combined presence of ICAM-1 and IgG on insect cells. Engagement of receptor 2B4 by CD48 on insect cells induced weak polarization and no degranulation. However, coengagement of 2B4 and CD16 by their respective ligands resulted in granule polarization and cytotoxicity in the absence of leukocyte functional antigen-1–mediated adhesion to target cells. These data show that cytotoxicity by resting NK cells is controlled tightly by separate or cooperative signals from different receptors for granule polarization and degranulation

Validity and reliability of Resource Utilization Groups (RUG-III) in Finnish long-term care facilities

Resource Utilization Groups, Version III (RUG-III) is a case-mix system developed in the USA for classification of long-term care residents. This paper examines the validity and reliability of an adapted 22-group version of RUG-III (RUG-III/22) for use in long-term care facilities in Finland. Finnish cost weights for RUG-III/22 groups are calculated and different methods for their computation are evaluated. The study sample (1,964 residents) was collected in 1995 - 96 from ten long-term care facilities in Finland. RUG-III/22 alone explained 38.2% of the variance of total patient-specific (nursing + auxiliary staff) per diem cost. Resource use within RUG groups was relatively homogeneous. Other predictors of resource use included age, gender and length of stay. RUG-III/22 also met the standard for good reliability (i.e. a kappa value of 0.6 or higher) for crucial classification items, such as activities of daily living and high correlation between assessments based on relative cost.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/68924/2/10.1177_14034948990270030201.pd

Fibroblast growth factor 23, mineral metabolism and mortality among elderly men (Swedish MrOs)

Background: Fibroblast growth factor 23 (FGF23) is the earliest marker of disturbed mineral metabolism as renal function decreases. Its serum levels are associated with mortality in dialysis patients, persons with chronic kidney disease (CKD) and prevalent cardiovascular disease (CVD), and it is associated with atherosclerosis, endothelial dysfunction and left ventricular hypertrophy in the general population. The primary aim of this study is to examine the association between FGF23 and mortality, in relation to renal function in the community. A secondary aim is to examine the association between FGF23 and CVD related death. Methods: The population-based cohort of MrOS Sweden included 3014 men (age 69-81 years). At inclusion intact FGF23, intact parathyroid hormone (PTH), 25 hydroxyl vitamin D (25D), calcium and phosphate were measured. Mortality data were collected after an average of 4.5 years follow-up. 352 deaths occurred, 132 of CVD. Association between FGF23 and mortality was analyzed in quartiles of FGF23. Kaplan-Meier curves and Log-rank test were used to examine time to events. Cox proportional hazards regression was used to examine the association between FGF23, in quartiles and as a continuous variable, with mortality. The associations were also analyzed in the sub-cohort with estimated glomerular filtration rate (eGFR) above 60 ml/min/1.73 m(2). Results: There was no association between FGF23 and all-cause mortality, Hazard ratio (HR) 95% confidence interval (CI): 1.02 (0.89-1.17). For CVD death the HR (95% CI) was 1.26 (0.99 - 1.59)/(1-SD) increase in log(10) FGF23 after adjustment for eGFR, and other confounders. In the sub-cohort with eGFR > 60 ml/min/1.73 m(2) the HR (95% CI) for CVD death was 55% (13-111)/(1-SD) increase in log(10) FGF23. Conclusions: FGF23 is not associated with mortality of all-cause in elderly community living men, but there is a weak association with CVD death, even after adjustment for eGFR and the other confounders. The association with CVD death is noticeable only in the sub-cohort with preserved renal function

Falls Predict Fractures Independently of FRAX Probability: A Meta-Analysis of the Osteoporotic Fractures in Men (MrOS) Study

Although prior falls are a well-established predictor of future fracture, there is currently limited evidence regarding the specific value of falls history in fracture risk assessment relative to that of other clinical risk factors and bone mineral density (BMD) measurement. We therefore investigated, across the three Osteoporotic Fractures in Men (MrOS) Study cohorts, whether past falls predicted future fracture independently of FRAX and whether these associations varied with age and follow-up time. Elderly men were recruited from MrOS Sweden, Hong Kong, and USA. Baseline data included falls history (over the preceding 12 months), clinical risk factors, BMD at femoral neck, and calculated FRAX probabilities. An extension of Poisson regression was used to investigate the associations between falls, FRAX probability, and incident fracture, adjusting for age, time since baseline, and cohort in base models; further models were used to investigate interactions with age and follow-up time. Random-effects meta-analysis was used to synthesize the individual country associations. Information on falls and FRAX probability was available for 4365 men in USA (mean age 73.5 years; mean follow-up 10.8 years), 1823 men in Sweden (mean age 75.4 years; mean follow-up 8.7 years), and 1669 men in Hong Kong (mean age 72.4 years; mean follow-up 9.8 years). Rates of past falls were similar at 20%, 16%, and 15%, respectively. Across all cohorts, past falls predicted incident fracture at any site (hazard ratio [HR] = 1.69; 95% confidence interval [CI] 1.49, 1.90), major osteoporotic fracture (MOF) (HR = 1.56; 95% CI 1.33, 1.83), and hip fracture (HR = 1.61; 95% CI 1.27, 2.05). Relationships between past falls and incident fracture remained robust after adjustment for FRAX probability: adjusted HR (95% CI) any fracture: 1.63 (1.45, 1.83); MOF: 1.51 (1.32, 1.73); and hip: 1.54 (1.21, 1.95). In conclusion, past falls predicted incident fracture independently of FRAX probability, confirming the potential value of falls history in fracture risk assessment. © 2017 The Authors. Journal of Bone and Mineral Research Published by Wiley Periodicals Inc