THE ROLE OF FOLIC ACID IN THE TREATMENT OF MAJOR DEPRESSIVE DISORDER

Objective: Depressive symptoms are the most common neuropsychiatric manifestation of folic acid deficiency. The objective of this research is to determine the role of folic acid in the treatment of major depressive disorder (MDD). Method: 60 outpatients with MDD and matched 30 healthy controls constituted the sample. The Personal Information Form was used to determine the sociodeniographic features of the patient and the control groups. Hamilton Depression Rating Scale (HDRS) and the criteria of MDD of DSM-IV were used to diagnos the MDD. 30 of the outpatients randomly selected as first group they were given fluoxetine (20 mgs per day), the remainders we given fluoxeline (20 mgs per day) and folic acid (5 mgs per day) as the second group. HDRS was applied lo the patients in 7^th, 14^th, 28^th, 42^th days and to the three groups at the beginning, and was measured serum folic acid levels 0 ^th, 14^th,. 28 ^th, 42^th days. After calculating HDRS scores and serum folic acid levels, the data were run on SPSS. The following statistical analyses were used in order to evaluate the data: variance analysis, student's t test. Mann-Whitney U test and Tukey's test. Result At the beginning, HDRS scores of first, second and control groups were 29.10, 26.93, 7.90 respectively. The mean serum folate levels were lower in the first and the second groups than It, controls. The decrease of HDRS scores were found to be faster in the second group than the first group. However, in 42^nd day, the difference between HDRS scores of the two groups was not significant statistically. Conclusion: As a result, one can say that adding folate to the treatment of MDD may reduce the occurrence and duration of MDD and increase the efficiency of antidepressant treatment

Use of Lactobacillus farciminis to improve antioxidant status of Tuj lambs

The aim of this study was to investigate the effects of Lactobacillus farciminis on growth traits and antioxidant status in preweaning and postweaning Tuj lambs. Twenty lambs were divided into four groups, regardless of gender, with a mean live weight of 7.81 ± 0.50 kg. At the start of the experiment, the average age of the lambs was seven days. During the six-week preweaning period, control (C) lambs were fed with colostrum only, and Lactobacillus farciminis was given orally to the treated lambs at 1 g/day/lamb (L1), 2 g/day/lamb (L2) or 4 g/day/lamb (L3). The experiment continued for a total of 22 weeks. During the first six weeks, bodyweight (BW) increased significantly in L1 at the sixth week. Also during this period, bodyweight gain (BWG) in L2 at 2 - 3 weeks and in L3 at 5 - 6 weeks differed from C. In the subsequent period, BW and BWG were not affected by probiotic supplementation. The effects of probiotic supplementation on malondialdehyde (MDA), nitric oxide (NO), superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) were significant throughout the experiment, with the effect on glutathione (GSH) also being important in the first six weeks. Thus, Lactobacillus farciminis provided orally to Tuj breed lambs could be used to improve their antioxidant status without compromising growth

Isospin structure of one- and two-phonon GDR excitations

Isospin is included in the description of Coulomb excitation of multiple giant isovector dipole resonances. In the excitation of even-even nuclei, a relevant portion of the excitation strength is shown to be associated with 1+ two-phonon states, which tends to be hindered or completely supressed in calculations in which the isospin degree of freedom is not considered. We find that the excitation cross sections is strongly dependent on the ground state isospin.Comment: 8 pages, 2 figure

Paleoseismic History of the Dead Sea Fault Zone

International audienceThe aim of this entry is to describe the DSF as a transform plate boundary pointing out the rate of activedeformation, fault segmentation, and geometrical complexities as a control of earthquake ruptures. Thedistribution of large historical earthquakes from a revisited seismicity catalogue using detailedmacroseismic maps allows the correlation between the location of past earthquakes and fault segments.The recent results of paleoearthquake investigations (paleoseismic and archeoseismic) with a recurrenceinterval of large events and long-term slip rate are presented and discussed along with the identification ofseismic gaps along the fault. Finally, the implications for the seismic hazard assessment are also discussed

Advances in Rootstock Breeding of Nut Trees: Objectives and Strategies

The production and consumption of nuts are increasing in the world due to strong economic returns and the nutritional value of their products. With the increasing role and importance given to nuts (i.e., walnuts, hazelnut, pistachio, pecan, almond) in a balanced and healthy diet and their benefits to human health, breeding of the nuts species has also been stepped up. Most recent fruit breeding programs have focused on scion genetic improvement. However, the use of locally adapted grafted rootstocks also enhanced the productivity and quality of tree fruit crops. Grafting is an ancient horticultural practice used in nut crops to manipulate scion phenotype and productivity and overcome biotic and abiotic stresses. There are complex rootstock breeding objectives and physiological and molecular aspects of rootstock–scion interactions in nut crops. In this review, we provide an overview of these, considering the mechanisms involved in nutrient and water uptake, regulation of phytohormones, and rootstock influences on the scion molecular processes, including long-distance gene silencing and trans-grafting. Understanding the mechanisms resulting from rootstock × scion × environmental interactions will contribute to developing new rootstocks with resilience in the face of climate change, but also of the multitude of diseases and pests.info:eu-repo/semantics/publishedVersio

Fermi Gamma-ray Space Telescope: High-Energy Results from the First Year

The Fermi Gamma-ray Space Telescope (Fermi) was launched on June 11, 2008 and began its first year sky survey on August 11, 2008. The Large Area Telescope (LAT), a wide field-of-view pair-conversion telescope covering the energy range from 20 MeV to more than 300 GeV, is the primary instrument on Fermi. While this review focuses on results obtained with the LAT, the Gamma-ray Burst Monitor (GBM) complements the LAT in its observations of transient sources and is sensitive to X-rays and gamma-rays with energies between 8 keV and 40 MeV. During the first year in orbit, the Fermi LAT has observed a large number of sources that include active galaxies, pulsars, compact binaries, globular clusters, supernova remnants, as well as the Sun, the Moon and the Earth. The GBM and LAT together have uncovered surprising characteristics in the high-energy emission of gamma-ray bursts (GRBs) that have been used to set significant new limits on violations of Lorentz invariance. The Fermi LAT has also made important new measurements of the Galactic diffuse radiation and has made precise measurements of the spectrum of cosmic-ray electrons and positrons from 20 GeV to 1 TeV.Comment: 39 pages, 16 figure