Fitting Algorithms for Optical and Beam Parameters in Transfer Lines with Application to the LHC Injection Line T12

As part of the commissioning with beam of the transfer line TI2 and TI8 from the SPS to the LHC [1], a series of optics measurements has been conducted. The paper presents the results in terms of Twiss parameters (including the dispersion), emittance and momentum spread obtained from the combination of trajectory and beam profile measurements. Profiting from the redundancy of monitors, there is a possibility of applying different fitting algorithms to retrieve beam parameters and to extract information on the optics of the line. The results from the different fit methods applied to the data will be compared with the expected values and cross-checked with independent measurements

Expansion of knowledge about intellectualization of the user task launch process in the distributed computational system

The relevance of expanding knowledge about the intellectualization of the task launch process in distributed computing systems is grounded, describes the content of a generalized system of knowledge representation about the intelligent service management of the global task queue, presents techniques for the organization and functioning of the intellectual serviceОбоснована актуальность расширения знаний об интеллектуализации процесса запуска заданий в распределённых вычислительных системах, описано содержание обобщённой системы представления знаний об интеллектуальном сервисе управления глобальной очередью заданий, представлены приёмы организации и функционирования интеллектуального сервис

Machine studies during beam commissioning of the SPS-to-LHC transfer lines

Through May to September 2008, further beam commissioning of the SPS-to-LHC transfer lines was performed. For the first time, optics and dispersion measurements were also taken in the last part of the lines, and into the LHC. Extensive trajectory and optics studies were conducted, in parallel with hardware checks. In particular dispersion measurements and their comparison with the beam line model were analysed in detail and led to propose the addition of a dispersion-free steering algorithm in the existing trajectory correction program. Its effectiveness was simulated and is briefly discussed

ИССЛЕДОВАНИЕ НАНО- И МИКРОСТРУКТУРЫ БИОМАТЕРИАЛОВ ДЛЯ РЕГЕНЕРАТИВНОЙ МЕДИЦИНЫ МЕТОДОМ СКАНИРУЮЩЕЙ ЗОНДОВОЙ НАНОТОМОГРАФИИ

Aim. To perform a study of three-dimensional micro- and nanostructure of porous biocompatible scaffolds and quantitative analysis of nanoscale porosity parameters.Materials and methods. Three-dimensional porous scaffolds made from spidroin rS1/9 (recombinant analog of spider dragline protein) were produced by salt leaching technique. Dimensions of macropores in produced three-imensional scaffolds were in range from 200 to 400 microns. The study of three-dimensional structure of scaffolds was carried out by scanning probe nanotomography technique with the use of experimental setup combining ultramicrotome and scanning probe microscope. Results. Three-dimensional nanotomographical reconstruction of scaffold macropore wall structure is obtained. The formation of three-dimensional network of interconnected pores and channels with characteristic dimensions in range from 20 to 700 nm in the volume of macropore walls of studied scaffolds is observed. Mean pore diameter is 150 nm. Volume porosity of macropore walls is 22% while volume fraction of pores interconnected in large pore clusters is about 20% of all pore volume.Conclusion. Obtained as a result of the study quantitative characteristics of porous micro- and nanostructure of scaffolds show signifi cant degree of nanoscale porosity and percolation of macropore walls what correlates with reported high effi ciency of tissue regeneration on such scaffolds implanted in vivo. Use of scanning probe nanotomography technique for analysis of characteristics and topology of micro- and nanopore systems enables to improve effi ciency of development of novel biocompatible and biodegradable materials with predicted morphological, physical, chemical and biological characteristics.Цель. Провести исследование трехмерной микро- и наноструктуры пористых биосовместимых матриксов и выполнить количественный анализ наномасштабной пористости.Материалы и методы. Трехмерные пористые матриксы из высокоочищенного спидроина rS1/9 (рекомбинантного аналога белка паутины) были получены методом выщелачивания. Размер макропор полученных трехмерных матриксов составил от 200 до 400 мкм. Изучение трехмерной структуры матриксов производилось методом сканирующей зондовой нанотомографии при помощи экспериментальной установки, объединяющей ультрамикротом и сканирующий зондовый микроскоп.Результаты. Получена трехмерная нанотомографическая реконструкция структуры стенки макропоры матрикса. Установлено, что в объеме стенок макропор исследуемых матриксов формируется трехмерная сеть сообщающихся пор и каналов с размерами от 20 до 700 нм. Средний диаметр пор составляет 150 нм. Объемный коэффициент пористости стенок макропор составляет 22%, при этом объемная доля пор, взаимосвязанных между собой и соединяющихся в кластеры, составляет порядка 20% от объема всех пор.Заключение. Полученные в результате исследования количественные характеристики пористой микро- и наноструктуры матриксов показывают заметную степень наномасштабной пористости и проницаемости стенок макропор, что коррелирует с высокой эффективностью регенерации тканей на подобных матриксах при их имплантации in vivo. Использование метода сканирующей зондовой нанотомографии для анализа характеристик и топологии систем микро-и нанопор позволяет повысить эффективность разработок по созданию новых биосовместимых и биодеградируемых материалов с заданными морфологическими, физико-химическими и биологическими характеристиками

Membrane fusion mediated by ricin and viscumin

AbstractThe ribosome inactivating plant proteins (RIPs) ricin and viscumin but not Ricinus communis agglutinin are able induce vesicle–vesicle fusion. A model is suggested in which the toxicity of the RIPs is partially determined by their fusogenicity. Herein, fusion is hypothesized to allow the RIPs to leak across endocytic vesicles to approve their access to cytoplasmic ribosomes

Initial results from beam commissioning of the LHC beam dump system

Initial commissioning of the LHC beam dump system with beam took place in August and September 2008. The preparation, setting-up and the tests performed are described together with results of the extractions of beam into the dump lines. Analysis of the first detailed aperture measurements of the extraction channels and kicker performance derived from dilution sweep shapes are presented. The performance of the other equipment subsystems is summarised, in particular that of the dedicated dump system beam instrumentation

Laser Wire Scanner Compton Scattering Techniques for the Measurement of the Transverse Beam Size of Particle Beams at Future Linear Colliders

This archive summarizes a working paper and conference proceedings related to laser wire scanner development for the Future Linear Collider (FLC) in the years 2001 to 2006. In particular the design, setup and data taking for the laser wire experiments at PETRA II and CT2 are described. The material is focused on the activities undertaken by Royal Holloway University of London (RHUL).Comment: 61 page

ABOUT DIAGNOSTICS OF THE PATIENT WITH SUSPICION TO SEVERE ACUTE RESPIRATORY SYNDROME (SARS) IN CHITA CITY

A complex of diagnostic measures for detection of a suspected SARS patient is analyzed. Clinical course of the disease in dynamics especially at the early stages allowed to suspect SARS in a worker arrived from China. The diagnosis was cancelled on the basis of the clinical data and laboratory negative results. However, this case allowed to practically perfect tactics of interactions between different services during realization of anti-epidemic measures in a case of SARS suspicion including notification, hospital basis development and PCR-diagnostics adoption