Generalized Gravity and a Ghost

We show that generalized gravity theories involving the curvature invariants of the Ricci tensor and the Riemann tensor as well as the Ricci scalar are equivalent to multi- scalar-tensor gravities with four derivatives terms. By expanding the action around a vacuum spacetime, the action is reduced to that of the Einstein gravity with four derivative terms, and consequently there appears a massive spin-2 ghost in such generalized gravity theories in addition to a massive spin-0 field.Comment: 8 pages, a reference adde

Rofecoxib and cardiovascular adverse events in adjuvant treatment of colorectal cancer

Background Selective cyclooxygenase inhibitors may retard the progression of cancer, but they have enhanced thrombotic potential. We report on cardiovascular adverse events in patients receiving rofecoxib to reduce rates of recurrence of colorectal cancer. Methods All serious adverse events that were cardiovascular thrombotic events were reviewed in 2434 patients with stage II or III colorectal cancer participating in a randomized, placebo-controlled trial of rofecoxib, 25 mg daily, started after potentially curative tumor resection and chemotherapy or radiotherapy as indicated. The trial was terminated prematurely owing to worldwide withdrawal of rofecoxib. To examine possible persistent risks, we examined cardiovascular thrombotic events reported up to 24 months after the trial was closed. Results The median duration of active treatment was 7.4 months. The 1167 patients receiving rofecoxib and the 1160 patients receiving placebo were well matched, with a median follow-up period of 33.0 months (interquartile range, 27.6 to 40.1) and 33.4 months (27.7 to 40.4), respectively. Of the 23 confirmed cardiovascular thrombotic events, 16 occurred in the rofecoxib group during or within 14 days after the treatment period, with an estimated relative risk of 2.66 (from the Cox proportional-hazards model; 95% confidence interval [CI], 1.03 to 6.86; P = 0.04). Analysis of the Antiplatelet Trialists’ Collaboration end point (the combined incidence of death from cardiovascular, hemorrhagic, and unknown causes; of nonfatal myocardial infarction; and of nonfatal ischemic and hemorrhagic stroke) gave an unadjusted relative risk of 1.60 (95% CI, 0.57 to 4.51; P = 0.37). Fourteen more cardiovascular thrombotic events, six in the rofecoxib group, were reported within the 2 years after trial closure, with an overall unadjusted relative risk of 1.50 (95% CI, 0.76 to 2.94; P = 0.24). Four patients in the rofecoxib group and two in the placebo group died from thrombotic causes during or within 14 days after the treatment period, and during the follow-up period, one patient in the rofecoxib group and five patients in the placebo group died from cardiovascular causes. Conclusions Rofecoxib therapy was associated with an increased frequency of adverse cardiovascular events among patients with a median study treatment of 7.4 months’ duration. (Current Controlled Trials number, ISRCTN98278138.

understanding the roles of cytokines and neutrophil activity and neutrophil apoptosis in the protective versus deleterious inflammatory response in pneumonia

SummaryInflammation is a double-edged sword in the outcome of pneumonia. On the one hand, an effective and timely inflammatory response is required to eliminate the invading respiratory pathogen. On the other, a toxic and prolonged inflammatory response may result in lung injury and poor outcomes, even in those receiving advanced medical care. This review focuses on recent understanding of the dynamics of the cytokine response, neutrophil activity, and responsiveness to cytokines and neutrophil lifespan as major elements of lung inflammation resulting in favorable or poor outcomes in lung infection primarily due to pneumococcus and influenza virus. Although some progress has been made in our understanding of the molecular mechanisms of the pneumonia inflammation axis composed of cytokines modulating neutrophil activation and neutrophil apoptosis, important questions remain to be answered. The degree of neutrophil activation, generation of reactive oxygen species, and the release of granule antimicrobial peptides play a key role in microbial pathogen clearance; however, prolonged neutrophil activation may contribute to lung injury and poor outcomes in pneumonia. Molecular markers of the mechanisms regulating neutrophil survival and apoptosis may help in the identification of novel therapeutic targets to modulate inflammation by inducing timely neutrophil apoptosis. A major task is to identify the mechanisms of dysregulation in inflammation leading to toxic responses, thereby targeting a biomarker and enabling timely therapies to modulate inflammation

R2R^2 corrections to the cosmological dynamics of inflation in the Palatini formulation

We investigate the corrections to the inflationary cosmological dynamics due to a $R^2$ term in the Palatini formulation which may arise as quantum corrections to the effective Lagrangian in early universe. We found that the standard Friedmann equation will not be changed when the scalar field is in the potential energy dominated era. However, in the kinetic energy dominated era, the standard Friedmann equation will be modified and in the case of closed and flat universe, the Modified Friedmann equation will automatically require that the initial kinetic energy density of the scalar field must be in sub-Planckian scale.Comment: 11 pages, no figures. Accepted by Class.Quant.Grav.v2:References adde

Cosmological Evolution in 1/R-Gravity Theory

Recently, corrections of the $L(R)$ type to Einstein-Hilbert action that become important at small curvature are proposed. Those type of models intend to explain the observed cosmic acceleration without dark energy. We derive the full Modified Friedmann equation in the Palatini formulation of those modified gravity model of the $L(R)$ type. Then, we discuss various cosmological predictions of the Modified Friedmann equation.Comment: 7 pages, 5 figures. Accepted for publication in Class.Quant.Gra

Anisotropic Inflation and the Origin of Four Large Dimensions

In the context of (4+d)-dimensional general relativity, we propose an inflationary scenario wherein 3 spatial dimensions grow large, while d extra dimensions remain small. Our model requires that a self-interacting d-form acquire a vacuum expectation value along the extra dimensions. This causes 3 spatial dimensions to inflate, whilst keeping the size of the extra dimensions nearly constant. We do not require an additional stabilization mechanism for the radion, as stable solutions exist for flat, and for negatively curved compact extra dimensions. From a four-dimensional perspective, the radion does not couple to the inflaton; and, the small amplitude of the CMB temperature anisotropies arises from an exponential suppression of fluctuations, due to the higher-dimensional origin of the inflaton. The mechanism triggering the end of inflation is responsible, both, for heating the universe, and for avoiding violations of the equivalence principle due to coupling between the radion and matter.Comment: 24 pages, 2 figures; uses RevTeX4. v2: Minor changes and added references. v3: Improved discussion of slow-rol

Evidence for the role of EPHX2 gene variants in anorexia nervosa.

Anorexia nervosa (AN) and related eating disorders are complex, multifactorial neuropsychiatric conditions with likely rare and common genetic and environmental determinants. To identify genetic variants associated with AN, we pursued a series of sequencing and genotyping studies focusing on the coding regions and upstream sequence of 152 candidate genes in a total of 1205 AN cases and 1948 controls. We identified individual variant associations in the Estrogen Receptor-ß (ESR2) gene, as well as a set of rare and common variants in the Epoxide Hydrolase 2 (EPHX2) gene, in an initial sequencing study of 261 early-onset severe AN cases and 73 controls (P=0.0004). The association of EPHX2 variants was further delineated in: (1) a pooling-based replication study involving an additional 500 AN patients and 500 controls (replication set P=0.00000016); (2) single-locus studies in a cohort of 386 previously genotyped broadly defined AN cases and 295 female population controls from the Bogalusa Heart Study (BHS) and a cohort of 58 individuals with self-reported eating disturbances and 851 controls (combined smallest single locus P<0.01). As EPHX2 is known to influence cholesterol metabolism, and AN is often associated with elevated cholesterol levels, we also investigated the association of EPHX2 variants and longitudinal body mass index (BMI) and cholesterol in BHS female and male subjects (N=229) and found evidence for a modifying effect of a subset of variants on the relationship between cholesterol and BMI (P<0.01). These findings suggest a novel association of gene variants within EPHX2 to susceptibility to AN and provide a foundation for future study of this important yet poorly understood condition

The conformal frame freedom in theories of gravitation

It has frequently been claimed in the literature that the classical physical predictions of scalar tensor theories of gravity depend on the conformal frame in which the theory is formulated. We argue that this claim is false, and that all classical physical predictions are conformal-frame invariants. We also respond to criticisms by Vollick [gr-qc/0312041], in which this issue arises, of our recent analysis of the Palatini form of 1/R gravity.Comment: 9 pages, no figures, revtex; final published versio