Aider les Risk Managers à qualifier les mauvaises pratiques : les dessous de la disposition Sapin II

International audienceL’objet de cet article est d’envisager une problématique essentielle en gestion des risques et inhérente à la fonction de risk manager, laquelle concerne la question de la capacité des gestionnaires de risques à réaliser et à remonter à la gouvernance des alertes sur les risques de l’organisation. En abordant des perspectives tant théoriques que managériales et en nous appuyant sur différentes études de cas dans le secteur des assurances et des mutuelles, nous traitons cette question de recherche tant du point de vue de l’aspect normatif traditionnel du risk manager que de celui qui lui semble de plus en plus dévolu, comme c’est le cas en France avec le dispositif Sapin II, de garant d’une orthodoxie de gestion dépassant le strict cadre légal

Association between endocrine disruptor contamination and thyroid hormone homeostasis in Belgian type 1 diabetic children.

peer reviewe

Relevance of cycle threshold values in mass screening by reverse-transcription-PCR during COVID-19 pandemic in Belgium: a decision-making support?

peer reviewedAim: The Belgium’s strategy against COVID-19 was partly based on mass screening. Here, we reported the results observed in a Belgian mass screening center. Materials & methods: Between October 2020 and February 2021, 32,089 samples were collected analyzed with reverse-transcription PCR (Thermo Fisher Scientific kits and apparatus). Patients were categorized according to their contagiousness (extrapolated from the cycle threshold [Ct] values and the recommendation of Sciensano). Results: We observed association between Ct values and age, with higher Ct observed in extreme age groups (75 years). Conclusion: The analysis of the evolution of the contagiousness of these patients tested twice within a 7-day period showed the relevancy of the recommendation edited by Sciensano

Comparison of combined thickness of the uterus and the placenta between 2 breeds of mares and their potential relationship with estrogens during normal pregnancy.

peer reviewe

Development and validation of a liquid chromatography coupled to mass spectrometer (LC-MS) method for the simultaneous quantification of estrone-3-sulfate, progesterone, estrone and estradiol in serum of mares and American bisons

peer reviewedSteroid concentrations in serum are fluctuating during pregnancy of many mammal species. The current knowledge about endocrinology of gestation is mainly based on immunoassays. However, the lack of specificity of these assays hampers the reliability of the results. In the present work, we developed and validated a methodology associating liquid chromatography (LC) and mass spectrometry (MS) to simultaneously quantify, with high specificity and accuracy, estrone-3-sulfate (E3S), progesterone (PRO), estrone (E1) and estradiol (E2) in serum of two different mammal species. The sample preparation procedure is based on a simple protein precipitation and a derivatization with dansyl chloride. After the chromatographical separation, compounds were analyzed with a triple-quadrupole mass spectrometer operating in multiple reaction monitoring. Mare and American bison serum samples were analyzed with the validated method and results were compared with concentrations measured with commercial radioimmunoassay (RIA), enzyme linked immunosorbent assay (ELISA) and chemiluminescent microparticle immunoassay (CMIA). Following these criterions: relative standard deviation <15% and relative bias <15%, lower limits of quantification of 0.5 ng/mL (E3S), 0.1 ng/mL (PRO) and 2 pg/mL (E1 and E2) were achieved. Most of the comparison between immunoassays and LC-MS showed poor correlation and proportional differences. Our LC-MS method is able to simultaneously quantify several steroid hormones with high specificity, accuracy and sensitivity in serum of two different mammal species. Our method constitutes a useful and performant tool for veterinary clinicians and LC-MS should thus be used to update and refine the current knowledge about the endocrinology of pregnancy in mammals

Impact of antenatal exposure to a mixture of persistent organic pollutants on intellectual development

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Methicillin-Resistant Staphylococcus aureus, Geneva, Switzerland, 1993–2005

Molecular characterization of methicillin-resistant Staphylococcus aureus (MRSA) strains different from those of an endemic healthcare-associated clone was conducted over 13 years in Geneva, Switzerland. We demonstrated strain diversity, including clones rarely found in Europe. Local epidemiology of community-associated MRSA is diverse and is evolving by importation and transmission of new strains

Global Distribution of Panton-Valentine Leukocidin–positive Methicillin-resistant Staphylococcus aureus, 2006

Some formerly continent-specific clones have now spread around the worl