1,642 research outputs found
The art of the wilderness : a field guide to integrating art + outdoor education
This thesis serves as both a comprehensive review of the fields of art and outdoor education, and as a practical handbook. Through an exploration of the definitions of art and wilderness to the pedagogy of art, outdoor, and experimental education, this thesis endeavors to make evident meaningful ways of learning. Interdisciplinary learning and multiple intelligence theory support a holistic and interconnected approach to education. Place-based and project-based learning emphasize a multidimensional line of inquiry rooted within a meaningful and personal context. The goal of integrating art + outdoor education is to design learning adventures that cultivate: creativity, leadership, problem-solving, collaboration, challenge, and inspiration. Through a comparison of the pedagogy of art and outdoor education, points of intersection, overlap, and difference emerge. Exemplars are provided from singular to broad, showing how the combined power of art + outdoor education has impacted local communities and national institutions, and created lasting social and political effects. Finally, an appendix of lesson plans, workshops, program outlines, and outdoor artist resources is offered as a field guide to applying art + outdoor education in a variety of contexts. Throughout the thesis, hand-drawn illustrations interpret the academic context while digital photographs provide documentation of experiences. The thesis is encased within a map of the John Muir Trail, in honor of the naturalist, environmental philosopher, and early advocate for the preservation of the wilderness within the United States
From Trusteeship to Containment: American Involvement in Vietnam 1945-1950
The American involvement in Vietnam has motivated extensive scholarship and reflection from diverse segments of American society. The Vietnamese war for independence and the dynamics and nature of American intervention have been approached from the perspectives of many different disciplines and from all points on the political continuum. The majority of these works address, either directly or implicitly, the fundamental issue of how American involvement can be explained and understood.
The historiography of American involvement in Vietnam covers a wide range of interpretations of the impetus behind the initial commitment, the reasons for progressive escalation, and the rationales for why the United States didn\u27t win. Though categorizing these analyses runs the risk of oversimplification, in the interest of clarity they are classifiable in terms of the central imperatives behind intervention which they address. The salient issues these scholars bring to light can be further subdivided in that some are concerned with the motivations of intervention and others with the decision making process. The interpretations to be discussed herein base the fact or character of United States involvement on the imperatives of the balance of power, the capitalist system, American ideology, the bureaucratic establishment, domestic electoral politics, and the concept of credibility.
The balance of power approach bases American decision making toward Vietnam in pragmatism and traditional power politics. The proponents of this approach interpret American actions as the result of realistic consideration of the international situation and of the necessities of national security. This interpretation takes two main directions: one finds the motivation behind involvement in the need to maintain the balance of world power with the Soviet Union, and the other sees the maintenance of Western power on Asia as the determining factor
See No Evil, Hear No Evil, Speak No Evil: The Poetics of Violence in Isaac Babel\u27s Red Cavalry
Senior Project submitted to The Division of Languages and Literature of Bard Colleg
Inciting inflammation: the RAGE about tumor promotion
Mechanisms of innate and adaptive immunity play a pivotal role in the development of cancer. Chronic inflammation can drive tumor development, but antitumor immunity can also restrict or even prevent tumor growth. New data show that feed-forward signals downstream of the receptor for advanced glycation end-products (RAGE) can fuel chronic inflammation, creating a microenvironment that is ideal for tumor formation
Granulocyte/macrophage colony-stimulating factor and accessory cells modulate radioprotection by purified hematopoietic cells
Granulocyte/macrophage colony-stimulating factor (GM-CSF) promotes the survival, proliferation, and differentiation of myeloid lineage cells and regulates chemotaxis and adhesion. However, mice in which the genes encoding GM-CSF (Gmcsf) or the β common subunit of the GM-CSF receptor (βc) are inactivated display normal steady-state hematopoiesis. Here, we show that host GM-CSF signaling strongly modulates the ability of donor hematopoietic cells to radioprotect lethally irradiated mice. Although bone marrow mononuclear cells efficiently rescue Gmcsf mutant recipients, fetal liver cells and Sca1+ lin−/dim marrow cells are markedly impaired. This defect is partially attributable to accessory cells that are more prevalent in bone marrow. In contrast, Gmcsf-deficient hematopoietic stem cells demonstrate normal proliferative potentials. Short-term survival is also impaired in irradiated βc mutant recipients transplanted with fetal liver or bone marrow. These data demonstrate a nonredundant function of GM-CSF in radioprotection by donor hematopoietic cells that may prove relevant in clinical transplantation
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Fouling formation of an olefin in the presence of oxygen and thiophenol
A kinetic model was developed to predict the fouling rate for autoxidation of indene in the presence of thiophenol. The kinetic constants were determined by analyzing the fouling data obtained with and without thiophenol. An initial rapid formation of hydroperoxide was observed in the presence of thiophenol; however, the product(s) formed by thiophenol was found to inhibit further formation of hydroperoxide. The maximum concentration of hydroperoxide and gum were about the same for experiments with and without thiophenol; however, the maximum was reached faster for runs with thiophenol. The effects of bulk temperature, and concentration of thiophenol and oxygen on the fouling rate were analyzed using the fouling model developed previously
Milk fat globule epidermal growth factor–8 blockade triggers tumor destruction through coordinated cell-autonomous and immune-mediated mechanisms
Carcinogenesis reflects the dynamic interplay of transformed cells and normal host elements, but cancer treatments typically target each compartment separately. Within the tumor microenvironment, the secreted protein milk fat globule epidermal growth factor–8 (MFG-E8) stimulates disease progression through coordinated αvβ3 integrin signaling in tumor and host cells. MFG-E8 enhances tumor cell survival, invasion, and angiogenesis, and contributes to local immune suppression. We show that systemic MFG-E8 blockade cooperates with cytotoxic chemotherapy, molecularly targeted therapy, and radiation therapy to induce destruction of various types of established mouse tumors. The combination treatments evoke extensive tumor cell apoptosis that is coupled to efficient dendritic cell cross-presentation of dying tumor cells. This linkage engenders potent antitumor effector T cells but inhibits FoxP3+ T reg cells, thereby achieving long-term protective immunity. Collectively, these findings suggest that systemic MFG-E8 blockade might intensify the antitumor activities of existing therapeutic regimens through coordinated cell-autonomous and immune-mediated mechanisms
Immunotherapy of lung cancer: An update
In Germany lung cancer is the leading cause of cancer-associated death in men. Surgery, chemotherapy and radiation may enhance survival of patients suffering from lung cancer but the enhancement is typically transient and mostly absent with advanced disease; eventually more than 90% of lung cancer patients will die of disease. New approaches to the treatment of lung cancer are urgently needed. Immunotherapy may represent one new approach with low toxicity and high specificity but implementation has been a challenge because of the poor antigenic characterization of these tumors and their ability to escape immune responses. Several different immunotherapeutic treatment strategies have been developed. This review examines the current state of development and recent advances with respect to non-specific immune stimulation, cellular immunotherapy ( specific and non-specific), therapeutic cancer vaccines and gene therapy for lung cancer. The focus is primarily placed on immunotherapeutic cancer treatments that are already in clinical trial or well progressed in preclinical studies. Although there seems to be a promising future for immunotherapy in lung cancer, presently there is not standard immunotherapy available for clinical routine
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