3,608 research outputs found
First Long-Term Application of Squeezed States of Light in a Gravitational-Wave Observatory
We report on the first long-term application of squeezed vacuum states of
light to improve the shot-noise-limited sensitivity of a gravitational-wave
observatory. In particular, squeezed vacuum was applied to the German/British
detector GEO600 during a period of three months from June to August 2011, when
GEO600 was performing an observational run together with the French/Italian
Virgo detector. In a second period squeezing application continued for about 11
months from November 2011 to October 2012. During this time, squeezed vacuum
was applied for 90.2% (205.2 days total) of the time that science-quality data
was acquired with GEO600. Sensitivity increase from squeezed vacuum application
was observed broad-band above 400Hz. The time average of gain in sensitivity
was 26% (2.0dB), determined in the frequency band from 3.7kHz to 4.0kHz. This
corresponds to a factor of two increase in observed volume of the universe, for
sources in the kHz region (e.g. supernovae, magnetars). We introduce three new
techniques to enable stable long-term application of squeezed light, and show
that the glitch-rate of the detector did not increase from squeezing
application. Squeezed vacuum states of light have arrived as a permanent
application, capable of increasing the astrophysical reach of
gravitational-wave detectors.Comment: 4 pages, 4 figure
PAD5: RETROSPECTIVE EVALUATION OF CONCOMITANT GASTROINTESTINAL DRUG USE WITH NSAID THERAPY AMONG PATIENTS WITH ARTHRITIS
Modulation of Fibrosis in Systemic Sclerosis by Nitric Oxide and Antioxidants
Systemic sclerosis (scleroderma: SSc) is a multisystem, connective tissue disease of unknown aetiology characterized by vascular dysfunction, autoimmunity, and enhanced fibroblast activity resulting in fibrosis of the skin, heart, and lungs, and ultimately internal organ failure, and death. One of the most important and early modulators of disease activity is thought to be oxidative stress. Evidence suggests that the free radical nitric oxide (NO), a key mediator of oxidative stress, can profoundly influence the early microvasculopathy, and possibly the ensuing fibrogenic response. Animal models and human studies have also identified dietary antioxidants, such as epigallocatechin-3-gallate (EGCG), to function as a protective system against oxidative stress and fibrosis. Hence, targeting EGCG may prove a possible candidate for therapeutic treatment aimed at reducing both oxidant stress and the fibrotic effects associated with SSc
Self-reported pregnancy exposures and placental DNA methylation in the MARBLES prospective autism sibling study.
Human placenta is a fetal-derived tissue that offers a unique sample of epigenetic and environmental exposures present in utero. In the MARBLES prospective pregnancy study of high-risk younger siblings of children with autism spectrum disorder (ASD), pregnancy and environmental factors collected by maternal interviews were examined as predictors of placental DNA methylation, including partially methylated domains (PMDs), an embryonic feature of the placental methylome. DNA methylation data from MethylC-seq analysis of 47 placentas of children clinically diagnosed at 3 years with ASD or typical development using standardized assessments were examined in relation to: child's gestational age, birth-weight, and diagnosis; maternal pre-pregnancy body mass index, smoking, education, parity, height, prenatal vitamin and folate intake; home ownership; pesticides professionally applied to lawns or gardens or inside homes, pet flea/tick pouches, collars, or soaps/shampoos used in the 3 months prior to or during pregnancy. Sequencing run, order, and coverage, and child race and sex were considered as potential confounders. Akaike information criterion was used to select the most parsimonious among candidate models. Final prediction models used sandwich estimators to produce homoscadisticity-robust estimates of the 95% confidence interval (CI) and P-values controlled the false discovery rate at 5%. The strongest, most robust associations were between pesticides professionally applied outside the home and higher average methylation over PMDs [0.45 (95% CI 0.17, 0.72), P = 0.03] and a reduced proportion of the genome in PMDs [-0.42 (95% CI - 0.67 to -0.17), P = 0.03]. Pesticide exposures could alter placental DNA methylation more than other factors
Tuberculous meningitis in children: reducing the burden of death and disability
Tuberculous meningitis disproportionately affects young children. As the most devastating form of tuberculosis, it is associated with unacceptably high rates of mortality and morbidity even if treated. Challenging to diagnose and treat, tuberculous meningitis commonly causes long-term neurodisability in those who do survive. There remains an urgent need for strengthened surveillance, improved rapid diagnostics technology, optimised anti-tuberculosis drug therapy, investigation of new host-directed therapy, and further research on long-term functional and neurodevelopmental outcomes to allow targeted intervention. This review focuses on the neglected field of paediatric tuberculous meningitis and bridges current clinical gaps with research questions to improve outcomes from this crippling disease
A new cross-layer dynamic spectrum access architecture for TV White Space cognitive radio applications
As evermore applications and services are developed for wireless devices, the dramatic growth in user data traffic has
led to the legacy channels becoming congested with the corresponding imperative of requiring more spectra. This has
motivated both regulatory bodies and commercial companies to investigate strategies to increase the efficiency of the existing spectrum. With the emergence of cognitive radio technology, and the transference of TV channels from analogue to digital platforms, a unique opportunity to exploit spectrum by mobile digital service providers has emerged, commonly referred to as TV White Space (TVWS). One of the challenges in utilising TVWS spectrum is reliable primary user (PU) detection which is essential as any unlicensed secondary user has no knowledge of the PU and thereby can generate interference. This paper addresses the issue of PU detection by introducing a new dynamic spectrum access algorithm that exploits the unique properties of how digital TV (DTV) frequencies are deployed. A fuzzy logic inference model based on an enhanced detection algorithm (EDA) is used to resolve the inherent uncertain nature of DTV signals. Simulation results confirm EDA significantly improves the detection probability of a TVWS channel compared to existing PU detection techniques, while providing consistently low false positive detections. The paper also analyses the impact of the hidden node problem on EDA by modelling representative buildings and proposes a novel solution
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Cognitive Radio and TV White Space (TVWS) Applications
As more user applications emerge for wireless devices, the corresponding amount of traffic is rapidly expanding, with the corollary that ever-greater spectrum capacity is required. Service providers are experiencing deployment blockages due to insufficient bandwidth being available to accommodate such devices. TV White Space (TVWS) represents an opportunity to supplement existing licensed spectrum by exploiting unlicensed resources. TVWS spectrum has materialised from the unused TV channels in the switchover from analogue to digital platforms. The main obstacles to TVWS adoption are reliable detection of primary users (PU) i.e., TV operators and consumers, allied with specifically, the hidden node problem. This chapter presents a new Generalised Enhanced Detection Algorithm (GEDA) that exploits the unique way Digital Terrestrial TV (DTT) channels are deployed in different geographical areas. GEDA effectively transforms an energy detector into a feature sensor to achieve significant improvements in detection probability of a DTT PU. Furthermore, by framing a novel margin strategy utilising a keep out contour, the hidden node issue is resolved, and a viable secondary user sensing solution formulated. Experimental results for a cognitive radio TVWS model have formalised both the bandwidth and throughput gains secured by TVWS users with this new paradigm
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High resolution gamma spectroscopy well logging system
A Gamma Spectroscopy Logging System (GSLS) has been developed to study sub-surface radionuclide contamination. The absolute counting efficiencies of the GSLS detectors were determined using cylindrical reference sources. More complex borehole geometries were modeled using commercially available shielding software and correction factors were developed based on relative gamma-ray fluence rates. Examination of varying porosity and moisture content showed that as porosity increases, and as the formation saturation ratio decreases, relative gamma-ray fluence rates increase linearly for all energies. Correction factors for iron and water cylindrical shields were found to agree well with correction factors determined during previous studies allowing for the development of correction factors for type-304 stainless steel and low-carbon steel casings. Regression analyses of correction factor data produced equations for determining correction factors applicable to spectral gamma-ray well logs acquired under non-standard borehole conditions
Cost-benefit analysis for commissioning decisions in GEO600
Gravitational wave interferometers are complex instruments, requiring years
of commissioning to achieve the required sensitivities for the detection of
gravitational waves, of order 10^-21 in dimensionless detector strain, in the
tens of Hz to several kHz frequency band. Investigations carried out by the
GEO600 detector characterisation group have shown that detector
characterisation techniques are useful when planning for commissioning work. At
the time of writing, GEO600 is the only large scale laser interferometer
currently in operation running with a high duty factor, 70%, limited chiefly by
the time spent commissioning the detector. The number of observable
gravitational wave sources scales as the product of the volume of space to
which the detector is sensitive and the observation time, so the goal of
commissioning is to improve the detector sensitivity with the least possible
detector down time. We demonstrate a method for increasing the number of
sources observable by such a detector, by assessing the severity of
non-astrophysical noise contaminations to efficiently guide commissioning. This
method will be particularly useful in the early stages and during the initial
science runs of the aLIGO and adVirgo detectors, as they are brought up to
design performance.Comment: 17 pages, 17 figures, 2 table
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